NOVEL ANTI-HUMAN Tie2 ANTIBODY

Abstract

[problem] to provide an anti-human tie2 antibody which prevents or treats diabetic macular edema, diabetic retinopathy, or critical limb ischaemia by binding to human tie2 and activating human tie2. [solution] the inventors of the present invention studied anti-human tie2 antibodies and have provided an anti-human tie2 antibody including four heavy chain variable regions and four light chain variable regions. The heavy chain variable regions comprise an amino acid sequence from amino acid no. 1 to 122 of seq id no:2, and the light chain variable regions comprise an amino acid sequence from amino acid no. 1 to 113 of seq id no:4. One of the heavy chain variable regions and one of the light chain variable regions constitute one antigen-binding site, and the antibody includes four antigen-binding sites.