Stereochemically enriched compositions for delivery of nucleic acids

Abstract

Provided, in part, is a composition comprising one or more chemical entities of formula i, each of which is a compound of formula (i):a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof, the composition characterized in that greater than a first threshold amount of the total amount of chemical entities of formula i in the composition: are chemical entities of formula i.A, wherein the first threshold amount is 50%; or are chemical entities of formula i.B.1, wherein the first threshold amount is 25%; or are chemical entities of formula i.B.2, wherein the first threshold amount is 25%, wherein the chemical entities of formula i.A, i.B.1, and i.B.2, are described herein, and methods of using such compositions, for example, for the delivery of a polynucleotide