USE OF N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEIVER MODULATORS

Description

N-substituted indole derivatives as PGE2 receptor modulators

[0001] The present invention relates to novel N-substituted indole derivatives of formula (I) and their use as pharmaceuticals. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of formula (I), and their use as modulators of the PGE2 receptors EP2 (alias PTGER2, alias PGE2 Receptor EP2 Subtype) and / or EP4 (alias PTGER4, alias EP4R, alias PGE2 Receptor EP4 Subtype). The compounds of formula (I) may especially be used as single agents or in combination with one or more therapeutic agents and / or chemotherapy and / or radiotherapy and / or immunotherapy in the prevention / prophylaxis or treatment of cancers; in particular the prevention / prophylaxis or treatment of melanoma; lung cancer; bladder cancer; renal carcinomas; gastro-intestinal cancers; endometrial cancer; ovarian cancer; cervical cancer; and neuroblastoma.

[0002] Prostaglandin E2 (PGE2) is a bioactive lipid that can elicit a wide range of biological effects associated with inflammation and cancer. PGE2 belongs to the prostanoid family of lipids. Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of biological mediators termed prostanoids, consisting of prostaglandin PGD2, PGE2, PGF2a, prostacyclin PGI2, and thromboxane TXA2. Prostanoids function via activation of seven transmembrane G-protein-coupled receptors (GPCRs), in particular EP1, EP2, EP3, and EP4 are receptors for PGE2. Activation of both EP2 and EP4 by PGE2 stimulates adenylate cyclase, resulting in elevation of cytoplasmic cAMP levels to initiate multiple downstream events via its prototypical effector Protein kinase A. In addition, PGE2 is also able to signal via PI3K / AKT and Ras-MAPK / ERK signalling

[0003] Cancers figure among the leading causes of death worldwide. Tumors are comprised of abnormally proliferating malignant cancer cells but also of a functionally supportive microenvironment. This tumor microenvironment is comprised of a complex array of cells, extracellular matrix components, and signaling molecules and is established by the altered communication between stromal and tumor cells. As tumors expand in size, they elicit the production of diverse factors that can help the tumor to grow such as angiogenic factors (promoting ingrowth of blood vessels) or that can help to evade the attack of the host immune response. PGE2 is such an immuno-modulatory factor produced in tumors.

[0004] It is well established that COX2, mainly via PGE2, promotes overall growth of tumors and is upregulated and correlates with clinical outcome in a high percentage of common cancers, especially colorectal, gastric, esophageal, pancreatic, breast and ovarian cancer. High COX-2 and PGE2 expression levels are associated with neoplastic transformation, cell growth, angiogenesis, invasiveness, metastasis and immune evasion.

[0005] The finding that COX2 is over-expressed and plays an important role in carcinogenesis in gastrointestinal (GI) cancers including among others esophagus, gastric and colorectal cancers has led to the fact that COX-inhibitors (Coxibs), including Celecoxib, and other nonsteroidal anti-inflammatory drugs (NSAID), including aspirin, are among the most studied cancer chemopreventive agents in development today (for review see for example Wang R et al, Curr Pharm Des. 2013;19(1):115-25; Garcia Rodriguez LA et al, Recent Results Cancer Res. 2013;191:67-93, Sahin IH et al, Cancer Lett. 2014 Apr 10;345(2):249-57; Drew DA et al, Nat Rev Cancer 2016, 16:173; Brotons C et al, Am J Cardiovasc Drugs. 2015 Apr; 15(2):113)

[0006] In addition to COX2 and PGE2, also EP receptors, especially EP2 and EP4, are aberrantly over-expressed in multiple types of cancers, especially in gastro-intestinal (GI) cancers and pancreatic cancer. Furthermore, the overexpression of PGE2 and / or EP2 and / or EP4 correlates with diseases progression in some cancer types such as oesophageal squamous cell carcinoma (Kuo KT et al, Ann Surg Onc 2009; 16(2), 352-60); squamous cell carcinoma of the lung (Alaa M et al, Int J Oncol 2009, 34(3); 805-12); prostate cancer (Miyata Y et al, Urology 2013, 81(1):136-42); Badawi AF and Badr MZ Int J Cancer. 2003, 103(1):84-90); head and neck squamous cell carcinoma (Gallo 0 et al, Hum Pathol. 2002, 33(7):708-14).

[0007] In accordance to studies performed with Coxibs, in mice, knockout of either COX1, COX2, microsomal prostaglandin E synthase 1 (mPTGES1), EP2 or EP4 resulted in reduced tumor incidence and progression in different tumor models. Conversely, overexpression of COX2 or mPTGES1 in transgenic mice resulted in increased tumor incidence and tumor burden (for review see Nakanishi M. and Rosenberg D.W., Seminars in Immunopathology 2013, 35: 123-137; Fischer SM et al Cancer Prev Res (Phila) 2011 Nov;4(11):1728-35; Fulton AM et al Cancer Res 2006; 66(20); 9794-97).

[0008] Several pharmacological studies to inhibit tumor growth and progression using EP receptor antagonists or COX2 inhibitors in different tumor models have been conducted in mice. Among others, EP antagonists and / or COX2 inhibitors reduced tumor growth and metastasis in experimental models of colorectal cancer (e.g Yang L et al Cancer Res 2006, 66(19), 9665-9672; Pozzi A.et al JBC 279(28); 29797-29804), lung carcinomas (Sharma S et al Cancer Res 2005 65(12), 5211-5220), gastro-intestinal cancer (Oshima H et al Gastroenterology 2011, 140(2); 596-607; Fu SL et al world J Gastroenterol 2004, 10(13); 1971-1974), breast cancer (Kundu N et al, Breast Cancer Res Treat 117, 2009; 235-242; Ma X et al, Oncolmmunology 2013; Xin X et al Lab Investigation 2012, 1-14; Markosyan N et al; Breast Cancer Res 2013, 15:R75), prostate cancer (Xu S et al, Cell Biochem Biophys 2014, Terada et al Cancer Res 70(4) 2010; 1606-1615), pancreatic cancer (Al-Wadei HA et al, PLOS One 2012, 7(8):e43376; Funahashi H et al, Cancer Res 2007, 67(15):7068-71). COX2 inhibitors were approved for the treatment of familial adenomatous polyposis (FAP) which is an inherited pre-disposition syndrome for colorectal cancer, but later retracted due to cardiovascular side effects.

[0009] Mechanistically, PGE2 signalling is mainly involved in the crosstalk between tumor and stromal cells, thereby creating a microenvironment which is favourable for the tumor to grow. In particular, PGE2 signalling via EP2 and EP4 can for example (i) suppress the cytotoxicity and cytokine production of natural killer cells, (ii) skew the polarization of tumor-associated macrophages towards tumor-promoting M2 macrophages (see for example Nakanishi Y et al Carcinogenesis 2011, 32:1333-39), (iii) regulate the activation, expansion and effector function of both Tregs (regulatory T cells) and MDSC (myeloid derived suppressor cells), which are potent immunosuppressive cells that accumulate in tumors both in patients and in experimental animal models (see for example Sharma S et al, Cancer Res 2005, 5(12):5211-20; Sinha P et al Cancer Res 2007, 67(9), 4507-4513; Obermajer N et al, Blood 2011, 118(20):5498-5505); (iv) down-regulate IFN-γ, TNF-α IL-12 and IL-2 expression in immune cells such as natural killer cells, T-cells, dendritic cells and macrophages, impairing the ability of these immune cells to induce tumor cell apoptosis and restrain tumorigenesis (see for example Bao YS et al, Int Immunopharmacol. 2011;11 (10): 1599-605; Kim JG and Hahn YS, Immunol Invest. 2000;29(3):257-69; Demeuere CE et al, Eur J Immunol. 1997;27(12):3526-31; Mitsuhashi M et al, J Leukoc Biol. 2004;76(2):322-32; Pockaj BA et al, Ann Surg Oncol. 2004;11(3):328-39; (v) suppress activation, IL-2 responsivness, expansion and cytotoxicity of T-cells thereby contributing to local immunsuppresion (see for example Specht C et al, Int J Cancer 200191:705-712); (vi) inhibit maturation of dendritic cells, their ability to present antigens and to produce IL-12, resulting in abortive activation of cytotoxic T-cells (see for example Ahmadi M et al, Cancer Res 2008, 68(18):7250-9; Stolina M et al, J Immunol 2000, 164:361-70); (vii) regulate tumor angiogenesis (formation of new blood vessels for nutrient and oxygen supply) by enhancing endothelial cell motility and survival as well as by increasing the expression of VEGF (vascular endothelial growth factor) (see for example Zhang Y and Daaka Y, Blood 2011;118(19):5355-64; Jain S et al, Cancer Res. 2008; 68(19):7750-9; Wang and Klein, Molecular Carcinogenesis 2007, 46:912-923; (viii) enhance tumor cell survival (via PI3K / AKT and MAPK signalling). For review see for example Kalinski P, J Immunol 2012, 188(1), 21-28; Obermajer N et al, Oncoimmunology 1(5), 762-4; Greenhough A et al, carcinogenesis 2009, 30(3), 377-86; Wang D and Dubois RN, Gut 2006, 55, 115-122; Harris SG e al Trends Immunol 2002, 22, 144-150).

[0010] Coxibs have been shown to render tumor cells more sensitive to radiation and chemotherapy and several clinical trials have been performed or are ongoing combining Coxibs with radio- and / or chemotherapy (for review see e.g Ghosh N et al, Pharmacol Rep. 2010 Mar-Apr;62(2):233-44; Davis TW et al, Am J Clin Oncol. 2003, 26(4):S58-61; see also Higgins JP et al, Cancer Biol Ther 2009, 8:1440-49).

[0011] Furthermore, there is some evidence of additive effects and / or synergy between Coxibs and epidermal growth factor receptor (EGFR) inhibitors (see for example Zhang X et al, Clin Cancer Res. 2005, 11(17):6261-9; Yamaguchi NH et al, J Gastrointest Oncol. 2014, 5(1):57-66); and with aromatase inhibitors (see for example Generali D et al, Br J Cancer. 2014;111(1):46-54; Lustberg MB et all, Clin Breast Cancer. 2011 Aug; 11(4):221-7; Falandry C et al, Breast Cancer Res Treat. 2009 Aug;116(3):501-8); Chow LW et al, J Steroid Biochem Mol Biol. 2008, 111(1-2):13-7).

[0012] Moreover, additive / synergistic effects have been seen in different mouse tumor models when Aspirin (a COX1 / 2 inhibitor) was combined with and anti-VEGF antibody (Motz GT et al; Nat Med 2014 20(6):607) and this combination is currently under investigation in clinical trials (NCT02659384).

[0013] Recently, it has been shown that, if combined, different immunotherapeutic approaches can have enhanced antitumor efficacy. Due to the immune-modulatory properties of PGE2, Coxibs have thus also been used in combination with different immunotherapeutic approaches. In particular, additive or even synergistic effects could be observed when Coxibs were combined with dendritic cell vaccination in a rat glioma model and in a mouse mesothelioma or melanoma model (Zhang H et al, Oncol Res. 2013;20(10):447-55; Veltman JD et al, BMC Cancer. 2010;10:464; Toomey D et all, Vaccine. 2008 Jun 25;26(27-28):3540-9); with granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse brain tumors (Eberstål S et al, Int J Cancer. 2014 Jun 1;134(11):2748-53); with interferon gamma (IFN-γ) in brain tumors (Eberstål S et al, Cancer Immunol Immunother. 2012, 61(8):1191-9); with dendritic cell vaccination or with GM-CSF in a mouse breast cancer model (Hahn T et al, Int J Cancer. 2006,118(9):2220-31); and with adenoviral interferon beta (IFN-β) therapy in a mouse mesothelioma model (DeLong P et al, Cancer Res. 2003 Nov 15;63(22):7845-52). Along these lines, additive or even synergistic effects of Coxibs and / or EP2 and / or EP4 antagonists can also be envisaged with agents acting on cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) such as anti-CTLA-4 antibodies; anti-TIM-3 antibodies, anti-Lag-3 antibodies; anti-TIGIT antibodies; or, in particular, with agents acting on programmed cell death protein 1 (PD1), such as anti-PD1 or anti-PDL1 (programmed cell death ligand 1) antibodies (Yongkui Li et al Oncoimmunology 2016, 5(2):e1074374; Zelenay S et al, Cell 2015, 162; 1-14; WO2013 / 090552, which indicates a synergistic effect of dual EP2 and EP4 blockade in combination with agents acting on PD1).

[0014] Adenosine is another endogenous factor with anti-inflammatory properties that is generated through the activity of ectonucleotidases, CD39 and CD73, expressed on various cell types, including regulatory T cells (Treg) (Mandapathil M et al, J Biol Chem. 2010; 285(10):7176-86). Immune cells also respond to Adenosine, because they bear receptors for ADO, which are mainly of the A2a / A2b type (Hoskin DW, et al, Int J Oncol 2008, 32:527-535). Signaling via Adenosine receptors and EP2 / EP4 receptors converges on the cytoplasmic adenylyl cyclase, leading to up-regulation of cAMP. It was shown that Adenosine and PGE2 cooperate in the suppression of immune responses mediated by regulatory T cells (Mandapathil M et al, J Biol Chem. 2010; 285(36):27571-80; Caiazzo E et al, Biochem Pharmacol. 2016; 112:72-81).

[0015] Thus, the present EP2 and / or EP4 antagonists may be useful, alone, or in combination with with one or more therapeutic agents and / or chemotherapy and / or radiotherapy and / or immunotherapy; in particular in combination with chemotherapy, radiotherapy, EGFR inhibitors, aromatase inhibitors, anti-angiogenic drugs, adenosine inhibitors, immunotherapy such as especially PD1 and / or PDL1 blockade, or other targeted therapies; for the prevention / prophylaxis or treatment of cancers, notably for the prevention / prophylaxis or treatment of skin cancer including melanoma including metastatic melanoma; lung cancer including non-small cell lung cancer; bladder cancer including urinary bladder cancer, urothelial cell carcinoma; renal carcinomas including renal cell carcinoma, metastatic renal cell carcinoma, metastatic renal clear cell carcinoma; gastro-intestinal cancers including colorectal cancer, metastatic colorectal cancer, familial adenomatous polyposis (FAP), oesophageal cancer, gastric cancer, gallbladder cancer, cholangiocarcinoma, hepatocellular carcinoma, and pancreatic cancer such as pancreatic adenocarcinoma or pancreatic ductal carcinoma; endometrial cancer; ovarian cancer; cervical cancer; neuroblastoma; prostate cancer including castrate-resistant prostate cancer; brain tumors including brain metastases, malignant gliomas, glioblastoma multiforme, medulloblastoma, meningiomas; breast cancer including triple negative breast carcinoma; oral tumors; nasopharyngeal tumors; thoracic cancer; head and neck cancer; leukemias including acute myeloid leukemia, adult T-cell leukemia; carcinomas; adenocarcinomas; thyroid carcinoma including papillary thyroid carcinoma; choriocarcinoma; Ewing's sarcoma; osteosarcoma; rhabdomyosarcoma; Kaposi's sarcoma; lymphoma including Burkitt's lymphoma, Hodgkin's lymphoma, MALT lymphoma; multiple myelomas; and virally induced tumors.

[0016] In addition, selective or dual EP2 and / or EP4 antagonists may be useful in several other diseases or disorders responding for example to treatment with COX2 inhibitors, with the advantage that EP2 and / or EP4 antagonists should not possess the potential cardiovascular side effects seen with COX2 inhibitors, which are mainly due to interference with PGl2 and TXA2 synthesis (see for example Boyd MJ et al, bioorganic and medicinal chemistry letters 21, 484, 2011). For example, blockade of prostaglandin production by COX inhibitors is the treatment of choice for pain, including especially inflammatory pain and painful menstruation. Thus EP2 and / or EP4 and / or dual EP2 / EP4 antagonists may be useful for the treatment of pain, especially inflammatory pain. Evidence from EP2 knockout mice suggest that EP2 antagonists can be used for the treatment of inflammatory hyperalgesia (Reinold H et al, J Clin Invest 2005, 115(3):673-9). In addition, EP4 antagonists have beneficial effect in vivo in inflammatory pain models (eg Murase A, Eur J Pharmacol 2008; Clark P, J Pharmacol Exp Ther. 2008; Maubach KA Br J Pharmacol. 2009; Colucci J Bioorg Med Chem Lett. 2010, Boyd MJ et al, Bioorg Med Chem Lett 2011, Chn Q et al Br J Phramacol 2010, Nakao K et al, J Pharmacol Exp Ther. 2007 Aug;322(2):686-94). Administration of an EP2 in combination with an EP4 antagonist showed significant, but partial inhibition of joint inflammation in mouse collagen-induced arthritis model (Honda T et al J Exp Med 2006, 203(2):325-35).

[0017] EP2 and / or dual EP2 / EP4 antagonists may be of use to decrease female fertility, i.e. they have been shown to prevent pregnancy if used as contraceptive in macaques (Peluffo MC et al Hum Reprod 2014). EP2 knockout mice have decreased fertility, smaller litter sizes and reduced cumulus expansion (Matsumoto et al, Biology of reproduction 2001, 64; 1557-65; Hitzaki et al, PNAS 1999, 96(18), 10501-10506; Tilley SL J Clin Inves 1999, 103(11):1539-45; Kennedy CR et al, Nat Med 1999 5(2):217-20).

[0018] There is also rationale that EP2 and / or EP4 antagonists may be of use to prevent or treat endometriosis: for example EP2, EP3 and EP4 and COX2 are overexpressed in endometriosis cell lines and tissues (e.g. Santulli P et al J Clin Endocrinol Metab 2014, 99(3):881-90); antagonist treatment was shown to inhibit the adhesion of endometrial cells in vitro (Lee J et al Biol Reprod 2013, 88(3):77; Lee J et al Fertil Steril 201, 93(8):2498-506); COX2 inhibitors have been shown to reduce endometric lesions in mice via EP2 (Chuang PC et al, Am J Pathol 2010, 176(2):850-60); and antagonist treatment has been shown to induce apoptosis of endometric cells in vitro (Banu SK et al, MOI endocrinol 2009, 23(8) 1291-305).

[0019] Dual EP2 / EP4 antagonists, or the combination of a selective EP2 antagonists with a selective EP4 antagonist, may be of potential use for autoimmune disorders; e.g. they have been shown to be effective in mouse model for multiple sclerosis (MS) (Esaki Yet al PNAS 2010, 107(27):12233-8; Schiffmann S et al, Biochem Pharmacol. 2014, 87(4): 625-35; see also Kofler DM et al J Clin Invest 2014, 124(6):2513-22). Activation of EP2 / EP 4 signalling in cells in vitro (Kojima F et al Prostaglandins Other Lipid Mediat 2009, 89:26-33) linked dual or selective EP2 and / or EP4 antagonists to the treatment of rheumatoid arthritis. Also, elevated levels of PGE(2) have been reported in synovial fluid and cartilage from patients with osteoarthritis (OA) and it has been shown that PGE2 stimulates matrix degradation in osteoarthitis chondrocytes via the EP4 receptor (Attur M et al, J Immunol. 2008;181(7):5082-8).

[0020] EP4 overexpression is associated with enhanced inflammatory reaction in atherosclerotic plaques of patients (Cipollone F et al, Artherioscler Thromb Vasc Biol 2005, 25(9); 1925-31), thus the use of EP4 and / or dual EP2 / EP4 antagonists may be indicated for plaque stabilization and prevention / prophylaxis of acute ischemic syndromes. In addition, EP4 deficiency suppresses early atherosclerosis, by compromising macrophage survival (Babaev VR et al, Cell Metab. 2008 Dec;8(6):492-501)

[0021] EP2 and / or dual EP2 / EP4 antagonists may also be useful in the treatment of pneumonia: intrapulmonary administration of apoptotic cells demonstrated that PGE(2) via EP2 accounts for subsequent impairment of lung recruitment of leukocytes and clearance of Streptococcus pneumoniae, as well as enhanced generation of IL-10 in vivo (Medeiros AI et al J Exp Med 2009 206(1):61-8).

[0022] EP2 and / or dual EP2 / EP4 antagonists may in addition be useful for the treatment of neurodegenerative diseases (for review see Cimino PJ et al, Curr Med Chem. 2008;15(19):1863-9). EP2 receptor accelerates progression of inflammation in a mouse model of amyotrophic lateral sclerosis (ALS) (Liang X et al, Ann Neurol 2008, 64(3):304-14); COX2 inhibitors have been shown to be neuroprotective in rodent models of stroke, Parkinson disease and ALS (for review see Liang X et al J Mol Neurosci 2007, 33(1):94-9), decreased neurotoxicity was observed in EP2 knockout mice treated with parkinsonian toxican (Jin J et al, J Neuroinflammation 2007, 4:2), PGE2 via EP2 aggravates neurodegeneration in cultured rat cells (Takadera T et al, Life Sci 2006, 78(16): 1878-83); Reduced amyloid burden was observed in Alzheimer's disease mouse model if crossed with EP2 knockout mice (Liang X et al J Neurosci 2005, 25(44):10180-7; Keene CD etal, Am J Pathol. 2010, 177(1):346-54). EP2 null mice are protected from CD14-dependent / innate immunity mediated neuronal damage in neurodegenerative disease (Shie FS et al Glia 2005, 52(1):70-7); PGE2 via EP2 increases amyloid precursor protein (APP) expression in cultured rat microglial cells (Pooler AM et al Neurosci. Lett. 2004, 362(2):127-30). EP2 antagonist limits oxidative damage from activation of innate immunity (intracranial injection of LPS) in the brain and could be used for Alzheimer or HIV associated dementia (Montine TJ et al, J Neurochem 2002, 83(2):463-70). In an Alzheimer's disease mouse model cognitive function could be improved by genetic and pharmacological inhibition of EP4 (Hoshino T et al, J Neurochem 2012, 120(5):795-805).

[0023] EP2 and / or dual EP2 / EP4 antagonists may also be useful to treat autosomal dominant polycystic kidney disease (ADPKD): PGE2 via EP2 induces cystogenesis of human renal epithelial cells; and EP2 was found to be overexpressed in patient samples (Elberg G et al, Am J Physiol Renal Physiol 2007, 293(5):F1622-32).

[0024] EP4 and / or dual EP2 / EP4 antagonists may also be useful to treat osteoporosis: PGE2 stimulates bone resorption mainly via EP4 and partially via EP2 (Suzawa T et all, Endocrinology. 2000 Apr;141(4):1554-9), EP4 knockout mice show impaired bone resorption (Miyaura C et al, J Biol Chem 2000, 275(26): 19819-23) and an EP4 antagonists showed partial inhibition of PGE(2)-stimulated osteoclastogenesis and osteoclastic bone resorption (Tomita M et al, Bone. 2002 Jan;30(1):159-63).

[0025] WO2008 / 152093 discloses selective EP2 receptor modulators which comprise an indole ring linked to the rest of the molecule in position 3, and a pyrimidine moiety which however is not substituted with a directly linked aromatic substituent. WO2006 / 044732 discloses pyrimidine compounds which are modulators of PGD2 claimed to be useful e.g. in the treatment of allergic diseases; however for example the exemplified compound CAS 1001913-77-4 has been tested to be inactive on both the EP2 and the EP4 receptor in the in vitro assay set out in the experimental part below. WO2008 / 006583 discloses pyrimidin derivatives which are ALK-5 inhibitors. WO2006 / 044732 and WO2008 / 039882 disclose certain pyrimidine derivatives as protaglandin D2 receptor antagonists. Pyrimidin-2-yl derivatives are disclosed in WO2013 / 020945, WO2012 / 127032, WO2011 / 144742, Bioorg. Med. Chem 2011, 21(13) 4108-4114 and Bioorg. Med. Chem 2011, 21(1) 66-75. Certain indole-1-acetamide compounds are known as library compounds, e.g. CAS 1448123-30-5 and CAS 1448075-88-4. Further compounds which are claimed to be active as anti-cancer agents are disclosed in WO2006 / 128129, WO2008 / 008059 and Bioorg. Med. Chem 2013, 21(2), 540-546. EP2711364 discloses indol derivatives useful for the treatment of cancer.

[0026] The present invention provides novel N-substituted indole derivatives of formula (I) which are modulators of the prostaglandin 2 receptors EP2 and / or EP4. Certain compounds of the present invention are dual antagonists of both the EP2 and the EP4 receptor. The present compounds may, thus, be useful for the prevention / prophylaxis or treatment of diseases which respond to the blockage of the EP2 receptors and / or the EP4 receptors such as especially cancers; as well as pain including especially inflammatory pain and painful menstruation; endometriosis; acute ischemic syndromes in atherosclerotic patients; pneumonia; neurodegenerative diseases including amyotrophic lateral sclerosis, stroke; Parkinson disease, Alzheimer's disease and HIV associated dementia; autosomal dominant polycystic kidney disease; and to control female fertility. 1) A first aspect of the invention relates to compounds of the formula (I) wherein (R 1< ) n represents (in addition to R 2< ) one, two or three optional substituents on the indole ring (i.e. n represents the integer 0, 1, 2, or 3), wherein said substituents are independently selected from (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially fluoro, chloro, or bromo), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; or two R 1< together form a group -O-CH 2 -O-, and the remaining R 1< , if present, represents halogen (especially fluoro or chloro); R 2< represents (C 1-4 )alkyl (especially methyl), halogen (especially chloro), or cyano; R 3< represents hydrogen, methyl or trifluoromethyl (especially hydrogen); R 43< and R 4b< independently represent hydrogen, methyl, or R 4a< and R 4b< together with the carbon atom to which they are attached represent a cycloprop-1,1-diyl group; R 5a< and R 5b< independently represent hydrogen, methyl, or R 5a< and R 5b< together with the carbon atom to which they are attached represent a cycloprop-1,1-diyl group; Ar 1< represents phenyl, or 5- or 6-membered heteroaryl (notably 5-membered heteroaryl, especially thiophenyl or thiazolyl); wherein said phenyl or 5- or 6-membered heteroaryl independently is mono-, di- or tri-substituted, wherein the substituents are independently selected from (C 1-6 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy); (C 1-3 )fluoroalkyl, wherein said (C 1-3 )fluoroalkyl is optionally substituted with hydroxy (especially trifluoromethyl, 2,2,2-trifluoro-1-hydroxy-ethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro, chloro, bromo); cyano; (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is unsubstituted or mono-substituted with amino (especially cyclopropyl, 1-amino-cyclopropyl); (C 4-6 )cycloalkyl containing a ring oxygen atom, wherein said (C 4-6 )cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy (especially 3-fluoro-oxetan-3-yl, 3-hydroxy-oxetan-3-yl, 3-methoxy-oxetan-3-yl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; nitro; -B(OH) 2 ; 2,2,2-trifluoro-1,1-dihydroxy-ethyl; -X 1< -CO-R 01< , wherein ▪ X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH(CH 3 )-*, -O-CH 2 -CH 2 -*), -NH-(C 1-3 )alkylene-* (especially -NH-CH 2 -*, -NH-CH(CH 3 )-*), -S-CH 2 -*, -CF 2 -, -CH=CH-, -C=C-, -NH-CO-*, -CO-, or (C 3-5 )cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O1< group; and ▪ R O1< represents -OH; -O-(C 1-4 )alkyl (especially ethoxy, methoxy); -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 3-6 )cycloalkyl-(C 1-3 )alkylene wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 1-3 )fluoroalkyl, phenyl, or-NH 2 ; -O-phenyl; -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1-4 )alkoxy, or -N[(C 1-4 )alkyl] 2 ; -O-CH 2 -O-CO-R O5< , wherein R O5< represents (C 1-4 )alkyl or (C 1-4 )alkoxy; or -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 (especially -O-CH 2 -CH 2 -N(CH 3 ) 2 ); (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; [wherein in particular such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, -NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-NH-SO 2 -phenyl, -CO-O-CH 3 , -CO-NH-SO 2 -ethyl, -CO-NH-SO 2 -NH 2 , -CO-O-CH 2 -COOH, -CO-O-CH 2 -CH 2 -N(CH 3 ) 2 , -CO-O-CH 2 -CO-N(CH 3 ) 2 , -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl, (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl-O-CO-, -CH 2 -COOH, -CH 2 -CO-O-ethyl, -CH 2 -CH 2 -COOH, -CF 2 -COOH, -CH=CH-COOH, -NH-CO-COOH, -CO-COOH, -O-CH 2 -CH 2 -COOH, -O-CH(CH 3 )-COOH, -NH-CH(CH 3 )-COOH, -NH-CH 2 -CO-O-CH 3 , -COO-phenyl, 1-carboxy-cyclopropan-1-yl, 1-carboxy-cyclopentan-1-yl]; -CO-CH 2 -CN; -CO-CH 2 -OH; -CO-H; 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl, 1-hydroxy-ethyl); dihydroxy-(C 2-4 )alkyl (especially 1,2-dihydroxyethyl); hydroxy-(C 2-4) alkoxy (especially 2-hydroxy-ethoxy); (C 1-4 )alkoxy-(C 2-4 )alkoxy (especially 2-methoxy-ethoxy); -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1; and wherein ■ R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl, -or -SO 2 -(C 1-4 )alkyl (wherein preferably at least one of R N1< and R N2< represents hydrogen); ■ or R N1< independently represents hydrogen or (C 1-4 )alkyl, and R N2< independently represents -CO-H, -CO-(C 1-3 )alkyl, -CO-(C 1-3 )alkylene-OH, or -CO-O-(C 1-3 )alkyl; ■ or R N1< and R N2< together with the nitrogen to which they are attached form a 4-, 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or -CH 2 -NH-SO 2 -CH 3 ; or -NH-CO-H, -N(C 2 H 5 )-CO-H, -NH-CO-C 2 H 5 , -NH-CO-CH 2 -CH 2 -OH, -NH-CO-O-CH 3 , -N(CH 3 )-CO-O-CH 3 ; or pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 1,1 -dioxo-isothiazolidin-2-yl, morpholin-4-yl, azetidin-1-yl, or piperidin-1-yl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, hydroxy-(C 2-4 )alkoxy, benzyloxy, or hydroxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -N(CH 3 ) 2 , -CO-NH-O-benzyl, or -CO-N(CH 3 ) 2 , -CO-NH-isopropyl, or -CO-NH-OH); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (wherein preferably at least one of R N5< and R N6< represents hydrogen; and wherein particular examples of such group -NH-CO-NR N5< R N6< are -NH-CO-NH 2 , and -NH-CO-NH-C 2 H 5 ); -SO 2 -R s1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl (wherein preferably at least one of R N7< and R N8< represents hydrogen; and wherein particular examples of such group -SO 2 -R s1< are -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 ); -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (encompassing its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl), or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (encompassing its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl); phenyl-oxy, wherein the phenyl is optionally mono-substituted with halogen (especially 4-fluorophenoxy); benzooxazol-2-yl; or -(CH 2 ) p -HET , wherein p represents the integer 0 or 1; and wherein HET represents a 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C 3-5 )cycloalkyl (especially cyclopropyl), or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially methyl); (especially such group -(CH 2 ) p -HET is 1H-tetrazol-5-yl, 1H-pyrazol-1-yl, 1 H-pyrazol-3-yl, 3-methyl-pyrazol-1-yl, 1-methyl-1H-pyrazol-3-yl, 5-methyl-1H-pyrazol-3-yl, 3,5-dimethyl-pyrazol-1-yl, 4-carboxy-1H-pyrazol-3-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 3-methyl-3H-imidazol-4-yl, 2-methyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-2-yl, [1,2,4]oxadiazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, 3-methyl-[1,2,4]oxadiazol-5-yl, 5-methyl-[1,3,4]oxadiazol-2-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, 4-methyl-thiazol-2-yl, 2-methyl-thiazol-4-yl, 2-amino-5-methyl-thiazol-4-yl, 4,5-dimethyl-thiazol-2-yl, 4-carboxy-thiazol-2-yl, 2-carboxy-thiazol-4-yl, 2-hydroxy-thiazol-4-yl, 2-amino-2-oxoethyl)thiazol-4-yl, isoxazol-3-yl, isoxazol-5-yl, 3-amino-isoxazol-5-yl, 3-hydroxy-isoxazol-5-yl, 3-methyl-isoxazol-5-yl, 4-methyl-isoxazol-5-yl, 4-carboxy-3-methyl-isoxazol-5-yl, oxazol-5-yl, 2-aminooxazol-5-yl, 2-methyl-oxazol-5-yl, 2-(2-carboxyethyl)-oxazol-5-yl, 2-(2-carboxyethyl)-4-methyl-oxazol-5-yl, 5-amino-[1,3,4]thiadiazol-2-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl, 4H-[1,2,4]triazol-3-yl, 1H-[1,2,4]triazol-1-yl, 2-methyl-2H-[1,2,4]triazol-3-yl, pyridin-2-yl, 4-fluoro-pyridin-2-yl, pyrimidin-2-yl, 5-fluoro-pyrimidin-2-yl, 5-methoxy-pyrimidin-2-yl, 4-methoxy-pyrimidin-2-yl, 6-methoxy-pyrimidin-4-yl, 6-dimethylamino-pyrimidin-4-yl, pyrazin-2-yl, 6-methoxy-pyrazin-2-yl, 6-methoxy-pyridazin-3-yl, pyrazol-1-yl-methyl, 1H-imidazol-4-yl, 3H-[1,2,3]triazol-4-yl, 5-methyl-1H-imidazol-4-yl, 1,2-dimethyl-1H-imidazol-4-yl, 1,5-dimethyl-1 H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl, 2-cyclopropyl-1H-imidazol-4-yl, 2-cyclopropyl-1-methyl-1H-imidazol-4-yl, oxazol-2-yl, 4,5-dimethyl-oxazol-2-yl, or pyridin-2-yl); or Ar 1< represents 8- to 10-membered bicyclic heteroaryl (especially indazolyl, benzoimidazolyl, indolyl, benzotriazolyl, benzooxazolyl, quinoxalinyl, isoquinolinyl, quinolinyl, pyrrolopyridinyl, or imidazopyridinyl); wherein said 8- to 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, di- or tri-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl); (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially trifluoromethoxy); halogen; cyano; hydroxy, or -(C 0-3 )alkylene-COOR O2< wherein R O2< representshydrogen or (C 1-4 )alkyl (especially methyl); (especially such 8- to 10-membered bicyclic heteroaryl is 1H-indazol-6-yl, 1-methyl-1H-indazol-6-yl, 3-methyl-1 H-indazol-6-yl, 3-carboxy-1H-indazol-6-yl, 1H-benzoimidazol-5-yl, 2-methyl-1H-benzoimidazol-5-yl, 2-trifluoromethyl-1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1-methyl-1H-indol-5-yl, 2-carboxy-1H-indol-5-yl, 7-carboxy-1H-indol-4-yl, 7-carboxy-1-methyl-1H-indol-4-yl, 1H-benzotriazol-5-yl, 2-methyl-benzooxazol-5-yl, 2-methyl-benzooxazol-6-yl, quinoxalin-6-yl, isoquinolin-7-yl, quinolin-6-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indazol-5-yl, 1H-pyrrolo[2,3-c]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, 1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl, imidazo[1,2-a]pyridin-6-yl, 3-methoxy-1H-indazol-6-yl, 6-methoxy-1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1H-indol-2-yl; preferably such 8- to 10-membered bicyclic heteroaryl is 1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1H-indol-2-yl, 1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1 H-indol-2-yl); or Ar 1< represents 8- to 10-membered partially aromatic fused bicyclic heterocyclyl comprising one to four heteroatoms independently selected from nitrogen, oxygen and sulfur (especially 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-1H-indazolyl, 2,3-dihydro-1H-benzo[d]imidazolyl, 2,3-dihydrobenzo[d]isoxazolyl, 2,3-dihydro-isoindolyl, 2,3-dihydro-benzooxazolyl, 1,2,3,4-tetrahydro-quinazolinyl, 1,2,3,4-tetrahydro-isoquinolinyl, or 1,2,3,4-tetrahydro-phthalazinyl); wherein said 8- to 10-membered heterocyclyl is linked to the rest of the molecule at the aromatic ring moiety; wherein said 8- to 10-membered heterocyclyl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo. (C 1-6 )alkyl (especially methyl, ethyl, propyl, butyl, isobutyl), and -(C 0-3 )alkylene-COOR O3< wherein R O3< representshydrogen or (C 1-3 )alkyl; (especially such 8- to 10-membered partially aromatic fused bicyclic heterocyclyl is 2,3-dihydro-benzofuran-5-yl, 2,3-dihydro-1H-indol-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, 3-oxo-2,3-dihydro-1H-indazol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl, 3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl, 2-isobutyl-1 -oxo-2,3-dihydro-isoindol-5-yl, 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 1-(carboxymethyl)-3-oxo-2,3-dihydro-1 H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl, or 1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl; preferably such group (Ar-III) is 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, or 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl).

[0027] The compounds of formula (I) may contain one or more stereogenic or asymmetric centers, such as one or more asymmetric carbon atoms, which are allowed to be present in (R)- as well as (S)-configuration. The compounds of formula (I) may further encompass compounds with one or more double bonds which are allowed to be present in Z-as well as E-configuration and / or compounds with substituents at a ring system which are allowed to be present, relative to each other, in cis- as well as trans-configuration. The compounds of formula (I) may thus be present as mixtures of stereoisomers or preferably as pure stereoisomers. Mixtures of stereoisomers may be separated in a manner known to a person skilled in the art.

[0028] In case a particular compound (or generic structure) is designated as (R)- or (S)-enantiomer, such designation is to be understood as referring to the respective compound (or generic structure) in enriched, especially essentially pure, enantiomeric form. Likewise, in case a specific asymmetric center in a compound is designated as being in (R)- or (S)-configuration or as being in a certain relative configuration, such designation is to be understood as referring to the compound that is in enriched, especially essentially pure, form with regard to the respective configuration of said asymmetric center. In analogy, cis- or trans-designations are to be understood as referring to the respective stereoisomer of the respective relative configuration in enriched, especially essentially pure, form. Likewise, in case a particular compound (or generic structure) is designated as Z- or E-stereoisomer (or in case a specific double bond in a compound is designated as being in Z- or E-configuration), such designation is to be understood as referring to the respective compound (or generic structure) in enriched, especially essentially pure, stereoisomeric form (or to the compound that is in enriched, especially essentially pure, form with regard to the respective configuration of the double bond).

[0029] The term "enriched", when used in the context of stereoisomers, is to be understood in the context of the present invention to mean that the respective stereoisomer is present in a ratio of at least 70:30, especially of at least 90:10 (i.e., in a purity of at least 70% by weight, especially of at least 90% by weight), with regard to the respective other stereoisomer / the entirety of the respective other stereoisomers.

[0030] The term "essentially pure", when used in the context of stereoisomers, is to be understood in the context of the present invention to mean that the respective stereoisomer is present in a purity of at least 95% by weight, especially of at least 99% by weight, with regard to the respective other stereoisomer / the entirety of the respective other stereoisomers.

[0031] The present invention also includes isotopically labelled, especially 2< H (deuterium) labelled compounds of formula (I) according to embodiments 1) to 31), which compounds are identical to the compounds of formula (I) except that one or more atoms have each been replaced by an atom having the same atomic number but an atomic mass different from the atomic mass usually found in nature. Isotopically labelled, especially 2< H (deuterium) labelled compounds of formula (I) and salts thereof are within the scope of the present invention. Substitution of hydrogen with the heavier isotope 2< H (deuterium) may lead to greater metabolic stability, resulting e.g. in increased in-vivo half-life or reduced dosage requirements, or may lead to reduced inhibition of cytochrome P450 enzymes, resulting e.g. in an improved safety profile. In one embodiment of the invention, the compounds of formula (I) are not isotopically labelled, or they are labelled only with one or more deuterium atoms. In a sub-embodiment, the compounds of formula (I) are not isotopically labelled at all. Isotopically labelled compounds of formula (I) may be prepared in analogy to the methods described hereinafter, but using the appropriate isotopic variation of suitable reagents or starting materials.

[0032] In this patent application, a bond drawn as a dotted line shows the point of attachment of the radical drawn. For example, the radical drawn below is the 2-methyl-1H-indol-1-yl group.

[0033] In some instances, the compounds of formula (I) may contain tautomeric forms. Such tautomeric forms are encompassed in the scope of the present invention. In case tautomeric forms exist of a certain residue, and only one form of such residue is disclosed or defined, the other tautomeric form(s) are understood to be encompassed in such disclosed residue. For example the group 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl is to be understood as also encompassing its tautomeric forms 2-hydroxy-1H-benzo[d]imidazol-5-yl and 2-hydroxy-3H-benzo[d]imidazol-5-yl. Similarly, 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (alternatively named 5-oxo-4H-[1,2,4]oxadiazol-3-yl) encompasses its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl, and 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (alternatively named 3-oxo-2H-[1,2,4]oxadiazol-5-yl) encompasses its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl.

[0034] Where the plural form is used for compounds, salts, pharmaceutical compositions, diseases and the like, this is intended to mean also a single compound, salt, or the like.

[0035] Any reference to compounds of formula (I) according to embodiments 1) to 31) is to be understood as referring also to the salts (and especially the pharmaceutically acceptable salts) of such compounds, as appropriate and expedient.

[0036] The term "pharmaceutically acceptable salts" refers to salts that retain the desired biological activity of the subject compound and exhibit minimal undesired toxicological effects. Such salts include inorganic or organic acid and / or base addition salts depending on the presence of basic and / or acidic groups in the subject compound. For reference see for example "Handbook of Phramaceutical Salts. Properties, Selection and Use.", P. Heinrich Stahl, Camille G. Wermuth (Eds.), Wiley-VCH, 2008; and "Pharmaceutical Salts and Co-crystals", Johan Wouters and Luc Quéré (Eds.), RSC Publishing, 2012.

[0037] Definitions provided herein are intended to apply uniformly to the compounds of formula (I), as defined in any one of embodiments 1) to 26), and, mutatis mutandis, throughout the description and the claims unless an otherwise expressly set out definition provides a broader or narrower definition. It is well understood that a definition or preferred definition of a term defines and may replace the respective term independently of (and in combination with) any definition or preferred definition of any or all other terms as defined herein. Whenever the group Ar 1< or substituents thereof are further defined, such definitions are intended to apply mutatis mutandis also to the groups (Ar-I), (Ar-II), (Ar-IV), (Ar-V), and (Ar-VI) and their respective substituents.

[0038] Whenever a substituent is denoted as optional, it is understood that such substituent may be absent, in which case all positions having a free valency (to which such optional substituent could have been attached to; such as for example in an aromatic ring the ring carbon atoms and / or the ring nitrogen atoms having a free valency) are substituted with hydrogen where appropriate.

[0039] The term "halogen" means fluorine, chlorine, bromine, or iodine; especially fluorine, chlorine, or bromine; preferably fluorine or chlorine.

[0040] The term "alkyl", used alone or in combination, refers to a saturated straight or branched chain hydrocarbon group containing one to six carbon atoms. The term "(C x-y )alkyl" (x and y each being an integer), refers to an alkyl group as defined before, containing x to y carbon atoms. For example a (C 1-6 )alkyl group contains from one to six carbon atoms. Examples of alkyl groups are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, 3-methyl-butyl, 2,2-dimethyl-propyl and 3,3-dimethyl-butyl. For avoidance of any doubt, in case a group is referred to as e.g. propyl or butyl, it is meant to be n-propyl, respectively n-butyl. Preferred are methyl and ethyl. Most preferred is methyl. Preferred for substituents of Ar 1< being phenyl or 5- or 6-membered heteroaryl are methyl, ethyl, propyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl.

[0041] The term "-(C x-y )alkylene-", used alone or in combination, refers to bivalently bound alkyl group as defined before containing x to y carbon atoms. Preferably, the points of attachment of a -(C 1-y )alkylene group are in 1,1-diyl, in 1,2-diyl, or in 1,3-diyl arrangement. In case a (C 0-y )alkylene group is used in combination with another substituent, the term means that either said substituent is linked through a (C 1-y )alkylene group to the rest of the molecule, or it is directly attached to the rest of the molecule (i.e. a (C 0 )alkylene group represents a direct bond linking said substituent to the rest of the molecule). The alkylene group -C 2 H 4 - refers to -CH 2 -CH 2 - if not explicitly indicated otherwise. For the linker X 1< , examples of (C 1-3 )alkylene groups are -CH 2 -, -CH(CH 3 )-, -C(CH 3 ) 2 -, and -CH 2 -CH 2 -, especially -CH 2 - and -CH 2 -CH 2 -. Examples of (C 0-3 )alkylene groups as used in the substituents -(C 0-3 )alkylene-COOR 02< and (C 0-3 )alkylene-COOR O3< , respectively, are (C 0 )alkylene, and methylene, respectively.

[0042] The term "alkoxy", used alone or in combination, refers to an alkyl-O- group wherein the alkyl group is as defined before. The term "(C x-y )alkoxy" (x and y each being an integer) refers to an alkoxy group as defined before containing x to y carbon atoms. For example a (C 1-4 )alkoxy group means a group of the formula (C 1-4 )alkyl-O- in which the term "(C 1-4 )alkyl" has the previously given significance. Examples of alkoxy groups are methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec.-butoxy and tert.-butoxy. Preferred are ethoxy and especially methoxy. Preferred for substituents of Ar 1< being phenyl or 5- or 6-membered heteroaryl are methoxy, ethoxy, propoxy, butoxy, isobutoxy.

[0043] The term "fluoroalkyl", used alone or in combination, refers to an alkyl group as defined before containing one to three carbon atoms in which one or more (and possibly all) hydrogen atoms have been replaced with fluorine. The term "(C x-y )fluoroalkyl" (x and y each being an integer) refers to a fluoroalkyl group as defined before containing x to y carbon atoms. For example a (C 1-3 )fluoroalkyl group contains from one to three carbon atoms in which one to seven hydrogen atoms have been replaced with fluorine. Representative examples of fluoroalkyl groups include trifluoromethyl, 2-fluoroethyl, 2,2-difluoroethyl and 2,2,2-trifluoroethyl. Preferred are (C 1 )fluoroalkyl groups such as trifluoromethyl. An example of "(C 1-3 )fluoroalkyl, wherein said (C 1-3 )fluoroalkyl is optionally substituted with hydroxy" is 2,2,2-trifluoro-1-hydroxy-ethyl.

[0044] The term "fluoroalkoxy", used alone or in combination, refers to an alkoxy group as defined before containing one to three carbon atoms in which one or more (and possibly all) hydrogen atoms have been replaced with fluorine. The term "(C x-y )fluoroalkoxy" (x and y each being an integer) refers to a fluoroalkoxy group as defined before containing x to y carbon atoms. For example a (C 1-3 )fluoroalkoxy group contains from one to three carbon atoms in which one to seven hydrogen atoms have been replaced with fluorine. Representative examples of fluoroalkoxy groups include trifluoromethoxy, difluoromethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy and 2,2,2-trifluoroethoxy. Preferred are (C 1 )fluoroalkoxy groups such as trifluoromethoxy and difluoromethoxy, as well as 2,2,2-trifluoroethoxy.

[0045] The term "cycloalkyl", used alone or in combination, refers to a saturated monocyclic hydrocarbon ring containing three to six carbon atoms. The term "(C x-y )cycloalkyl" (x and y each being an integer), refers to a cycloalkyl group as defined before containing x to y carbon atoms. For example a (C 3-6 )cycloalkyl group contains from three to six carbon atoms. Examples of cycloalkyl groups are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl. Preferred are cyclopropyl, cyclobutyl, and cyclopentyl; especially cyclopropyl. Examples of (C 3-6 )cycloalkyl groups wherein said (C 3-6 )cycloalkyl is optionally mono-substituted with amino are cyclopropyl, 1-amino-cyclopropyl. Examples of (C 3-6 )cycloalkyl groups wherein said (C 3-6 )cycloalkyl is mono-substituted with-COOH are 1-carboxy-cyclopropyl, 1-carboxy-cyclopentyl.

[0046] The term "-(C x-y )cycloalkylene-", used alone or in combination, refers to bivalently bound cycloalkyl group as defined before containing x to y carbon atoms. Preferably, the points of attachment of any bivalently bound cycloalkyl group are in 1,1-diyl, or in 1,2-diyl arrangement. Examples are cyclopropan-1,1-diyl, cyclopropan-1,2-diyl, and cyclopentan-1,1-diyl; preferred is cyclopropan-1,1-diyl.

[0047] Examples of (C 3-6 )cycloalkyl-oxy are cyclobutyl-oxy, and cyclopentyl-oxy.

[0048] Alkylated amino groups -N[(C 1-4 )alkyl] 2 as used in groups -X 1< -CO-R O1< , wherein R O1< represents -O-CH 2 -CO-R O4< , wherein R O4< represents-N[(C 1-4 )alkyl] 2 ; or wherein R O1< represents -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 are such that the two repective (C 1-4 )alkyl groups are independently selected. A preferred example of such amino group -N[(C 1-4 )alkyl] 2 is -N(CH 3 ) 2 .

[0049] The term "heterocycle", used alone or in combination, and if not explicitly defined in a broader or more narrow way, refers to a saturated monocyclic hydrocarbon ring containing one or two (especially one) ring heteroatoms independently selected from nitrogen, sulfur, and oxygen (especially one nitrogen atom, two nitrogen atoms, one nitrogen atom and one oxygen atom, or one nitrogen atom and one sulfur atom). The term "(C x-y )heterocycle" refers to such a heterocycle containing x to y ring atoms. Heterocycles are unsubstituted or substituted as explicitly defined.

[0050] The term "8- to 10-membered partially aromatic fused bicyclic heterocyclyl" refers to 5- or 6-membered aromatic ring which is fused to a 5- or 6-membered non-aromatic ring (especially a (C 5-6 )heterocycle as defined before), wherein said fused ring system comprises in total one to a maximum of four heteroatoms independently selected from nitrogen, oxygen and sulfur. Such 8- to 10-membered partially aromatic fused bicyclic heterocyclyl is linked to the rest of the molecule at the aromatic ring moiety. A preferred sub-group of such "8- to 10-membered partially aromatic fused bicyclic heterocyclyl" are phenyl groups which are fused to a (C 5-6 )heterocycle as defined before. Examples are 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-1H-indazolyl, 2,3-dihydro-1H-benzo[d]imidazolyl, 2,3-dihydrobenzo[d]isoxazolyl, and 2,3-dihydro-isoindolyl; and, in addition to the before listed: 2,3-dihydro-benzooxazol-6-yl, 2,3-dihydro-benzooxazol-5-yl, 1,2,3,4-tetrahydro-quinazolin-6-yl, 1,2,3,4-tetrahydro-quinazolin-7-yl, 1,2,3,4-tetrahydro-isoquinolin-6-yl, 1,2,3,4-tetrahydro-phthalazin-6-yl. The above groups are unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo, (C 1-6 )alkyl, and -(C 0-3 )alkylene-COOR O3< wherein R O3< representshydrogen or (C 1-3 )alkyl (especially methyl); especially substituents are independently selected from oxo, methyl, ethyl, propyl, butyl, isobutyl, wherein the substituents are preferably attached to the fused 5- or 6-membered non-aromatic ring. Oxo substituents are preferably attached to a ring carbon atom which is in alpha position to a ring nitrogen atom. Preferred examples of such 8- to 10-membered partially aromatic fused bicyclic heterocyclyl groups are 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl; as well as the oxosubstituted heterocyclyl groups 3-oxo-2,3-dihydro-1H-indazolyl, 2-oxo-2,3-dihydro-1H-benzo[d]imidazolyl, 3-oxo-2,3-dihydrobenzo[d]isoxazolyl, 2-oxo-1,3-dihydro-indolyl, 1-oxo-2,3-dihydro-isoindolyl, 2-oxo-2,3-dihydro-benzooxazolyl, 2-oxo-1,2,3,4-tetrahydro-quinazolinyl, 1-oxo-1,2,3,4-tetrahydro-isoquinolinyl, 1,4-dioxo-1,2,3,4-tetrahydro-phthalazinyl; wherein the above groups optionally carry one (further) substituent independently selected from (C 1-6 )alkyl, and -(C 0-3 )alkylene-COOR O3< wherein R O3< representshydrogen or (C 1-3 )alkyl (especially methyl). Particular examples are 2,3-dihydro-benzofuran-5-yl, 2,3-dihydro-1H-indol-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, 3-oxo-2,3-dihydro-1H-indazol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl, 3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl, 2-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl; and, in addition to the before listed: 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1 -methyl-3-oxo-2,3-dihydro-1 H-indazol-6-yl, 2-methyl-3-oxo-2,3-dihydro-1 H-indazol-6-yl, 1-(carboxymethyl)-3-oxo-2,3-dihydro-1 H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl, 1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl; preferred are 2,3-dihydro-1H-indol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, and 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl; and especially 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, and 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl.

[0051] For avoidance of doubt, certain groups having tautomeric forms which are considered predominantly non-aromatic, such as for example 2-oxo-2,3-dihydro-1H-benzo[d]imidazolyl groups, are defined herein as 8- to 10-membered partially aromatic fused bicyclic heterocyclyl groups, even though their corresponding tautomeric form (2-hydroxy-1H-benzo[d]imidazolyl) could also be considered as a 8- to 10-membered bicyclic heteroaryl group.

[0052] The term "aryl", used alone or in combination, means phenyl or naphthyl, especially phenyl. The above-mentioned aryl groups are unsubstituted or substituted as explicitly defined.

[0053] Examples of the substituent Ar 1< representing phenyl are especially those which are at least mono-substituted in para position with respect to the point of attachment of the rest of the molecule. In addition, such group Ar 1< representing phenyl may carry one or two further substituents, especially in one or both meta positions with respect to the point of attachment of the rest of the molecule. The respective substituents of such phenyl groups are as explicitly defined.

[0054] The term "heteroaryl", used alone or in combination, means a 5- to 10-membered monocyclic or bicyclic aromatic ring containing one to a maximum of four heteroatoms, each independently selected from oxygen, nitrogen and sulfur. Examples of such heteroaryl groups are 5-membered heteroaryl groups such as furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl; 6-membered heteroaryl groups such as pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl; and 8- to 10-membered bicyclic heteroaryl groups such as indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, benzoxadiazolyl, benzothiadiazolyl, thienopyridinyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrrolopyridinyl, pyrazolopyridinyl, pyrazolopyrimidinyl, pyrrolopyrazinyl, imidazopyridinyl, imidazopyridazinyl, and imidazothiazolyl. The above-mentioned heteroaryl groups are unsubstituted or substituted as explicitly defined.

[0055] For the substituent Ar 1< representing a "5- or 6-membered heteroaryl", the term means the above-mentioned 5- or 6-membered groups such as especially pyridinyl, pyrimidinyl, pyrrolyl, pyrazolyl, isoxazolyl, thiazolyl or thiophenyl. Notably, the term refers to 5-membered groups such as especially thiazolyl or thiophenyl; in particular thiophen-2-yl, thiophen-3-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl. Preferred is thiophenyl, especially thiophen-2-yl; or thiazolyl, especially thiazol-2-yl. The above groups are unsubstituted or substituted as explicitly defined.

[0056] For the substituent Ar 1< representing a "8- to 10-membered bicyclic heteroaryl" the term means the above-mentioned 8- to 10-membered heteroaryl groups. Notably, the term refers to 9- or 10-membered heteroaryl groups, such as especially indazolyl, benzoimidazolyl, indolyl, benzotriazolyl, benzooxazolyl, quinoxalinyl, isoquinolinyl, quinolinyl, and, in addition to the before listed: pyrrolopyridinyl, and imidazopyridinyl. The above groups are unsubstituted or substituted as explicitly defined. Particular examples are 1H-indazol-6-yl, 1-methyl-1H-indazol-6-yl, 3-methyl-1H-indazol-6-yl, 3-carboxy-1H-indazol-6-yl, 1H-benzoimidazol-5-yl, 2-methyl-1H-benzoimidazol-5-yl, 2-trifluoromethyl-1 H-benzoimidazol-5-yl, 1 H-indol-6-yl, 1 H-indol-5-yl, 1-methyl-1H-indol-5-yl, 2-carboxy-1H-indol-5-yl, 7-carboxy-1H-indol-4-yl, 7-carboxy-1-methyl-1 H-indol-4-yl, 1H-benzotriazol-5-yl, 2-methyl-benzooxazol-5-yl, 2-methyl-benzooxazol-6-yl, quinoxalin-6-yl, isoquinolin-7-yl, and quinolin-6-yl. In addition to the above-listed, further particular examples are 1 H-indol-2-yl, 1 H-indol-3-yl, 1 H-indol-4-yl, 1 H-indazol-5-yl, 1 H-pyrrolo[2,3-c]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, 1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl, imidazo[1,2-a]pyridin-6-yl, 3-methoxy-1H-indazol-6-yl, 6-methoxy-1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, 6-(methoxycarbonyl)-1H-indol-2-yl. Preferred examples are 1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1H-indol-2-yl, 1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, and 6-(methoxycarbonyl)-1H-indol-2-yl.

[0057] For the substituent "-(CH 2 ) p -HET , wherein p represents the integer 0 or 1, and wherein HET represents a 5- or 6-membered heteroaryl", such 5- or 6-membered heteroaryl is as defined before; notably a nitrogen containing 5- or 6-membered heteroaryl such as especially oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, pyridinyl, pyrimidinyl, pyridazinyl, or pyrazinyl. The above groups are unsubstituted or substituted as explicitly defined. The group -(CH 2 ) p - is preferably absent, i.e. p represents the integer 0 and the group HET is directly bound to the rest of the molecule. Particular examples of -(CH 2 ) p -HET are the -(CH 2 ) 0 -HET groups 1H-tetrazol-5-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 3-methyl-pyrazol-1-yl, 1-methyl-1H-pyrazol-3-yl, 5-methyl-1H-pyrazol-3-yl, 3,5-dimethyl-pyrazol-1-yl, 4-carboxy-1H-pyrazol-3-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 3-methyl-3H-imidazol-4-yl, 2-methyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-2-yl, [1,2,4]oxadiazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, 3-methyl-[1,2,4]oxadiazol-5-yl, 5-methyl-[1,3,4]oxadiazol-2-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, 4-methyl-thiazol-2-yl, 2-methyl-thiazol-4-yl, 2-amino-5-methyl-thiazol-4-yl, 4,5-dimethyl-thiazol-2-yl, 4-carboxy-thiazol-2-yl, 2-carboxy-thiazol-4-yl, 2-hydroxy-thiazol-4-yl, 2-amino-2-oxoethyl)thiazol-4-yl, isoxazol-3-yl, isoxazol-5-yl, 3-amino-isoxazol-5-yl, 3-hydroxy-isoxazol-5-yl, 3-methyl-isoxazol-5-yl, 4-methyl-isoxazol-5-yl, 4-carboxy-3-methyl-isoxazol-5-yl, oxazol-5-yl, 2-amino-oxazol-5-yl, 2-methyl-oxazol-5-yl, 2-(2-carboxyethyl)-oxazol-5-yl, 2-(2-carboxyethyl)-4-methyl-oxazol-5-yl, 5-amino-[1,3,4]thiadiazol-2-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl, 4H-[1,2,4]triazol-3-yl, 1H-[1,2,4]triazol-1-yl, 2-methyl-2H-[1,2,4]triazol-3-yl, pyridin-2-yl, 4-fluoro-pyridin-2-yl, pyrimidin-2-yl, 5-fluoro-pyrimidin-2-yl, 5-methoxy-pyrimidin-2-yl, 4-methoxy-pyrimidin-2-yl, 6-methoxy-pyrimidin-4-yl, 6-dimethylamino-pyrimidin-4-yl, pyrazin-2-yl, 6-methoxy-pyrazin-2-yl, and 6-methoxy-pyridazin-3-yl; as well as the -(CH 2 ) 1 -HET group pyrazol-1-yl-methyl. In addition to the above-listed, further particular examples are the -(CH 2 ) 0 -HET groups 3H-imidazol-4-yl, 3H-[1,2,3]triazol-4-yl, 5-methyl-1H-imidazol-4-yl,1,2-dimethyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl, 2-cyclopropyl-1H-imidazol-4-yl, 2-cyclopropyl-1-methyl-1H-imidazol-4-yl, oxazol-2-yl, 4,5-dimethyl-oxazol-2-yl, as well as pyridin-2-yl. For avoidance of doubt, certain groups having tautomeric forms which are predominantly aromatic, such as for example 3-hydroxy-isoxazolyl groups, are defined herein as heteroaryl groups, even though their corresponding tautomeric form 3-oxo-2,3-dihydro-2H-isoxazolyl could also be considered as a non-aromatic group.

[0058] The term "cyano" refers to a group -CN.

[0059] The term "oxo" refers to a group =0 which is preferably attached to a chain or ring carbon or sulfur atom as for example in a carbonyl group -(CO)-, or a sulfonyl group -(SO 2 )-.

[0060] Examples of "-(CH 2 ) m -NR N1< R N2< " groups as used for substituents of Ar 1< being phenyl or 5- or 6-membered heteroaryl are amino, methylamino, ethylamino, propylamino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, and morpholin-4-yl. Further examples are -CH 2 -NH-SO 2 -CH 3 ; -NH-CO-H, -N(C 2 H 5 )-CO-H, -NH-CO-C 2 H 5 , -NH-CO-CH 2 -CH 2 -OH, - NH-CO-O-CH 3 , -N(CH 3 )-CO-O-CH 3 , azetidin-1-yl, and piperidin-1-yl. Preferred examples of the substituents "-(CH 2 ) m -NR N1< R N2< wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl, -or -SO 2 -(C 1-4 )alkyl" as used for substituents of the group Ar 1< are those wherein at least one of R N1< and R N2< represents hydrogen, such as amino, methylamino, ethylamino, propylamino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, -NH-SO 2- methyl, -NH-SO 2 -ethyl, and (2,2,2-trifluoro-ethyl)-amino. Preferred examples of the substituents "-(CH 2 ) m -NR N1< R N2< wherein R N1< represents hydrogen or (C 1-4 )alkyl, and R N2< independently represents -CO-H, -CO-(C 1-3 )alkyl, -CO-(C 1 - 3 )alkylene-OH, or -CO-O-(C 1-3 )alkyl" as used for substituents of the group Ar 1< are those wherein R N1< represents hydrogen, methyl, or ethyl; and R N2< independently represents -CO-H, -CO-CH 3 , -CO-C 2 H 5 , -CO-C 2 H 4 -OH, or -CO-O-CH 3 . Examples of - NR N1< R N2< rings in the substituents "-(CH 2 ) m -NR N1< R N2< , wherein R N1< and R N2< together with the nitrogen to which they are attached form a 4, 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom" as used for substituents of the group Ar 1< are pyrrolidin-1-yl, morpholin-4-yl, isothiazolidin-2-yl, azetidin-1-yl, and piperidin-1-yl; wherein said groups are unsubstituted or substituted as explicitly defined. Particular examples of such -(CH 2 ) m -NR N1< R N2< groups are pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, and morpholin-4-yl; as well as azetidin-1-yl, and piperidin-1-yl.

[0061] Examples of a group "-NH-CO-NR N5< R N6< " as used for substituents of the group Ar 1< are ureido (-NH-CO-NH 2 ) and 3-ethylureido (-NH-CO-NH-C 2 H 5 ).

[0062] Examples of a group "-CO-NR N3< R N4< " as used for substituents of the group Ar 1< are preferably groups wherein at least one of R N3< and R N4< represents hydrogen (or less preferred, methyl). Particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-N(CH 3 ) 2 , -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-C 2 H 4 -N(CH 3 ) 2 , and -CO-NH-O-benzyl. Further examples are-CO-NH-isopropyl and -CO-NH-OH, as well as -CO-N(CH 3 ) 2 .

[0063] Examples of a group "-X 1< - CO-R 01< " as used for substituents of the group Ar 1< are especially the following groups: a) X 1< represents a direct bond; and R O1< represents -OH; (i.e. -X 1< -CO-R O1< represents -COOH); or b) X 1< represents a direct bond; and R O1< represents -O-(C 1-4 )alkyl (especially ethoxy, or methoxy); (i.e. -X 1< -COR O1< represents -CO-(C 1-4 )alkoxy (especially ethoxycarbonyl, methoxycarbonyl)); or c) X 1< represents a direct bond; and R O1< represents -NH-SO 2 -R S3< ; wherein R S3< represents (C 1-4 )alkyl; (C 3- 6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 3-6 )cycloalkyl-(C 1- 3 )alkylene wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 1-3 )fluoroalkyl; phenyl; or - NH 2 ; (i.e. -X 1< -CO-R O1< represents -CO-NH-SO 2 -R S3< wherein R S3< represents the above mentioned groups; notably methyl, ethyl, isopropyl, cyclopropyl, trifluoromethyl, phenyl, amino; especially -X 1< -CO-R O1< represents -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-NH-SO 2 -phenyl, -CO-NH-SO 2 -ethyl, or -CO-NH-SO 2 -NH 2 ); or d) X 1< represents (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH(CH 3 )-*, -O-CH 2 -CH 2- *), -NH-(C 1-3 )alkylene-* (especially -NH-CH 2 -*, -NH-CH(CH 3 )-*), -S-CH 2 -*, -CF 2 -, -CH=CH-, or -C=C- [in a sub-embodiment X 1< represents especially -O-CH 2 -*, -NH-CH 2 -*, -S-CH 2 -*, or (C 1- 3 )alkylene]; wherein the asterisks indicate the bond that is linked to the -CO-R O1< group; and R O1< represents -OH (i.e. -X 1< -CO-R O1< represents -X 1< -COOH wherein X 1< represents the above mentioned groups; especially -X 1< -CO-R O1< represents -O-CH 2 -COOH or -NH-CH 2 -COOH; as well as -CH 2 -COOH, -CH 2 -CH 2 -COOH, -CF 2 -COOH, -CH=CH-COOH, -C≡C-COOH, -O-CH 2 -CH 2 -COOH, -O-CH(CH 3 )-COOH, or -NH-CH(CH 3 )-COOH); or e) -X 1< represents -NH-CO-* or -CO-; wherein the asterisk indicates the bond that is linked to the -CO-R O1< group; and R O1< represents -OH (i.e. -X 1< -CO-R O1< represents -X 1< -COOH wherein X 1< represents the above mentioned groups; especially -X 1< -CO-R O1< represents -NH-CO-COOH, -CO-COOH); or f) X 1< represents (C 3-5 )cycloalkylene; and R O1< represents -OH; (i.e. -X 1< -CO-R O1< represents (C 3-6 )cycloalkyl which is mono-substituted with COOH; especially -X 1< -CO-R O1< represents 1-carboxy-cyclopropan-1-yl or 1-carboxy-cyclopentan-1-yl); or g) X 1< represents a direct bond; and R O1< represents -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1- 4 )alkoxy, or -N[(C 1-4 )alkyl] 2 ; especially -X 1< -CO-R O1< represents -CO-O-CH 2 -COOH; or wherein each of the groups a), b), c), d), e), f), and g) forms a particular sub-embodiment.

[0064] Compounds of Formula (I) containing a group "-X 1< -CO-R O1< " wherein X 1< represents -CH=CH- may be in E- or Z-configuration. Preferably, such groups are in E-configuration.

[0065] Whenever a group Ar 1< is substituted with a substituent comprising a carboxylic acid group -COOH (such as in the substituents -(C 0-3 )alkylene-COOR O2< wherein R O2< representshydrogen; -(C 0-3 )alkylene-COOR O3< wherein R O3< representshydrogen; or in the substituents -X 1< -CO-R O1< wherein R O1< represents -OH, especially in the -X 1< -CO-R O1< groups a), d), e) and f) above) such carboxylic acid group may be present in form of a prodrug group. In certain instances, compounds comprising such carboxylic acid prodrug groups may as such exhibit biological activity on the EP2 and / or EP4 receptor, whereas in other instances, such compounds comprising such carboxylic acid prodrug groups require (e.g. enzymatic) cleavage of the prodrug to exhibit biological activity on the EP2 and / or EP4 receptor. Prodrugs of the carboxylic acid functional group are well known in the art (see for example J. Rautio (Ed.) Prodrugs and Targeted Delivery: Towards Better ADME Properties, Volume 47, Wiley 2010,ISBN: 978-3-527-32603-7; H. Maag in Stella, V., Borchardt, R., Hageman, M., Oliyai, R., Maag, H.,Tilley, J. (Eds.) Prodrugs: Challenges and Rewards, Springer 2007, ISBN 978-0-387-49785-3).

[0066] Particular examples of prodrugs, for example suitable for -X 1< -COOH groups are: ester groups -X 1< -CO-O-P 1< wherein P 1< is for example (C 1-4 )alkyl; (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 3-6 )cycloalkyl-(C 1-3 )alkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 1-3 )fluoroalkyl; hydroxy-(C 2-4 )alkyl; or (C 1-4 )alkoxy-(C 2-4 )alkyl (especially P 1< is (C 1-4 )alkyl, in particular methyl or ethyl); groups -X 1< -CO-NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 3-6 )cycloalkyl-(C 1-3 )alkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 1-3 )fluoroalkyl, phenyl, -NH 2 ; (especially R S3< is (C 1-4 )alkyl, (C 3-6 )cycloalkyl, or phenyl; in particular methyl); groups -X 1< -CO-R O1< wherein R O1< represents -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1- 4 )alkoxy, or -N[(C 1-4 )alkyl] 2 (especially -CO-O-CH 2 -COOH, -CO-O-CH 2 -CO-N(CH 3 ) 2 ); groups -X 1< -CO-R O1< wherein R O1< represents -O-CH 2 -O-CO-R O5< , wherein R O5< represents (C 1-4 )alkyl or (C 1- 4 )alkoxy (especially -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl); groups -X 1< -CO-R O1< wherein R O1< represents -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 (especially -CO-O-CH 2 -CH 2 -N(CH 3 ) 2 ); and groups -X 1< -CO-R O1< wherein R O1< represents 5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-.

[0067] Examples of "hydroxy-(C 1-4 )alkyl" groups as used for substituents of the group Ar 1< are hydroxymethyl and 1-hydroxy-ethyl.

[0068] An example of "dihydroxy-(C 2-4 )alkyl" groups as used for substituents of the group Ar 1< is 1,2-dihydroxyethyl.

[0069] An example of "hydroxy-(C 2-4 )alkoxy" groups as used for substituents of the group Ar 1< is 2-hydroxy-ethoxy.

[0070] An example of "(C 1-4 )alkoxy-(C 2-4 )alkoxy" groups as used for substituents of the group Ar 1< is 2-methoxy-ethoxy.

[0071] Examples of a group "-SO 2 -R S1< " as used for substituents of the group Ar 1< are -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 .

[0072] Examples of a group " S-R S2< " as used for substituents of the group Ar 1< are methylsulfanyl, ethylsulfanyl, n-propylsulfanyl, isopropylsulfanyl, isobutylsulfanyl), cyclobutylsulfanyl, and (2-fluoro-vinyl)-sulfanyl.

[0073] An example of a "(C 1-4 )alkoxy-(C 2-4 )alkyl" group is 2-methoxyethyl.

[0074] An example of a "hydroxy-(C 2-4 )alkoxy" group is 2-hydroxy-ethoxy.

[0075] An example of a "hydroxy-(C 2 - 4 )alkyl" group is 2-hydroxy-ethyl.

[0076] An example of a "-CO-(C 1-4 )alkoxy" group as used for substituents of the group Ar 1< is ethoxycarbonyl. Such groups may also be useful as produgs of the respective -COOH substituent.

[0077] Whenever the word "between" is used to describe a numerical range, it is to be understood that the end points of the indicated range are explicitly included in the range. For example: if a temperature range is described to be between 40 °C and 80 °C, this means that the end points 40 °C and 80 °C are included in the range; or if a variable is defined as being an integer between 1 and 4, this means that the variable is the integer 1, 2, 3, or 4.

[0078] Unless used regarding temperatures, the term "about" placed before a numerical value "X" refers in the current application to an interval extending from X minus 10% of X to X plus 10% of X, and preferably to an interval extending from X minus 5% of X to X plus 5% of X. In the particular case of temperatures, the term "about" placed before a temperature "Y" refers in the current application to an interval extending from the temperature Y minus 10°C to Y plus 10°C, and preferably to an interval extending from Y minus 5°C to Y plus 5°C. Besides, the term "room temperature" as used herein refers to a temperature of about 25°C.

[0079] Further embodiments of the invention are presented hereinafter: 2) A second embodiment relates to compounds according to embodiment 1), wherein R 3< represents hydrogen. 3) Another embodiment relates to compounds according to embodiment 1), wherein R 3< represents methyl or trifluoromethyl. 4) Another embodiment relates to compounds according to any one of embodiments 1) to 3), wherein R 4a< and R 4b< both represent hydrogen. 5) Another embodiment relates to compounds according to any one of embodiments 1) to 4), wherein R 5a< and R 5b< both represent hydrogen. Particular compounds of formula (I) are compounds wherein R 4a< and R 4b< both represent hydrogen; and R 5a< and R 5b< both represent hydrogen. 6) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents phenyl, or 5- or 6-membered heteroaryl (notably 5-membered heteroaryl, especially thiophenyl or thiazolyl); wherein said phenyl or 5- or 6-membered heteroaryl independently is mono-, di- or tri-substituted; wherein one of said substituents is selected from (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl, wherein said (C 1-3 )fluoroalkyl is optionally substituted with hydroxy (especially 2,2,2-trifluoro-1 -hydroxy-ethyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is optionally mono-substituted with amino (especially 1-amino-cyclopropyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is optionally mono-substituted with -COOH (especially 1-carboxy-cyclopropyl, 1-carboxy-cyclopentyl); hydroxy; -X 1< -CO-R O1< , wherein ▪ X 1< represents a direct bond, -O-CH 2 -*, -NH-CH 2 -*, -S-CH 2 -*, or (C 1-3 )alkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O1< group; and ▪ R O1< represents -OH, -O-(C 1-4 )alkyl (especially ethoxy), or -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 3-6 )cycloalkyl-(C 1-3 )alkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 1-3 )fluoroalkyl, phenyl, or-NH 2 ; [wherein in a sub-embodiment such group -X 1< -CO-R O1< represents especially -COOH, -CO-(C 1-4 )alkoxy, -O-CH 2 -COOH, -NH-CH 2 -COOH, -CO-NH-SO 2 -(C 1-4 )alkyl, -CO-NH-SO 2 -(C 3-6 )cycloalkyl, or -CO-NH-SO 2 -phenyl; in particular, such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, -NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, or -CO-NH-SO 2 -phenyl]; -CO-CH 2 -CN; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl); -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 1); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, or (C 3-6 )cycloalkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, 2-oxopyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, or morpholin-4-yl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, hydroxy-(C 2-4 )alkoxy, or benzyloxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-O-C 2 H 4 -OH, - CO-NH-C 2 H 4 -N(CH 3 ) 2 , -CO-NH-O-benzyl); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl; (especially such group is -NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ) -SO 2 -R S1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl; (especially such group is -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 ) 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl, or -(CH 2 ) p -HET , wherein p represents the integer 0 or 1 (especially 0); and wherein HET represents a 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, or - NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, dimethylamino); and the remaining one or two of said substituents (if present) is / are independently selected from (C 1-6 )alkyl (especially methyl, ethyl, propyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; nitro; -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 0); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl (especially 2,2,2-trifluoro-ethyl), -or -SO 2 -(C 1-4 )alkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, -NH-SO 2- methyl, -NH-SO 2- ethyl, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl); -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; or phenyl-oxy, wherein the phenyl is optionally mono-substituted with halogen (especially 4-fluorophenoxy); or Ar 1< represents 8- to 10-membered bicyclic heteroaryl (especially indazolyl, benzoimidazolyl, indolyl, benzotriazolyl, benzooxazolyl, quinoxalinyl, isoquinolinyl, quinolinyl; or pyrrolopyridinyl, or imidazopyridinyl); wherein said 8- to 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, di- or tri-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl); (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); halogen; or-COOH; or Ar 1< represents 8- to 10-membered partially aromatic fused bicyclic heterocyclyl comprising one to four heteroatoms independently selected from nitrogen, oxygen and sulfur (especially 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-1H-indazolyl, 2,3-dihydro-1H-benzo[d]imidazolyl, 2,3-dihydrobenzo[d]isoxazolyl, 2,3-dihydro-isoindolyl; or 2,3-dihydro-benzooxazol-6-yl, or 2,3-dihydro-benzooxazol-5-yl, or 1,2,3,4-tetrahydro-quinazolin-6-yl, or 1,2,3,4-tetrahydro-quinazolin-7-yl, or 1,2,3,4-tetrahydro-isoquinolin-6-yl, or 1,2,3,4-tetrahydro-phthalazin-6-yl); wherein said 8- to 10-membered heterocyclyl is linked to the rest of the molecule at the aromatic ring moiety; wherein said 8- to 10-membered heterocyclyl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo and (C 1-6 )alkyl (especially methyl, ethyl, propyl, butyl, isobutyl). 7) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents phenyl, or 5- or 6-membered heteroaryl (notably 5-membered heteroaryl, especially thiophenyl or thiazolyl); wherein said phenyl or 5- or 6-membered heteroaryl independently is mono-, di- or tri-substituted; wherein one of said substituents is selected from (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl, wherein said (C 1-3 )fluoroalkyl is unsubstituted or mono-substituted with hydroxy (especially 2,2,2-trifluoro-1-hydroxy-ethyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is unsubstituted or mono-substituted with amino (especially 1-amino-cyclopropyl); (C 4-6 )cycloalkyl containing a ring oxygen atom, wherein said (C 4-6 )cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy (especially 3-fluoro-oxetan-3-yl, 3-hydroxy-oxetan-3-yl, 3-methoxy-oxetan-3-yl); hydroxy; -B(OH) 2 ; 2,2,2-trifluoro-1,1-dihydroxy-ethyl; -X 1< -CO-R O1< , wherein ▪ X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH(CH 3 )-*, -O-CH 2 -CH 2 -*), -NH-(C 1-3 )alkylene-* (especially -NH-CH 2 -*, -NH-CH(CH 3 )-*), -S-CH 2 -*, -CF 2 -, -CH=CH-, -C≡C-, -NH-CO-*, -CO-, or (C 3-5 )cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O 1< group; and ▪ R O 1< represents -OH; -O-(C 1-4 )alkyl (especially ethoxy, methoxy); -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 3-6 )cycloalkyl-(C 1-3 )alkylene wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 1-3 )fluoroalkyl, phenyl, or -NH 2 ; -O-phenyl; -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1-4 )alkoxy, or -N[(C 1-4 )alkyl] 2 ; -O-CH 2 -O-CO-R O5< , wherein R O5< represents (C 1-4 )alkyl or (C 1-4 )alkoxy; or -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 (especially -O-CH 2 -CH 2 -N(CH 3 ) 2 ); (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; [wherein in particular, such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, -NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-NH-SO 2 -phenyl, -CO-O-CH 3 , -CO-NH-SO 2 -ethyl, -CO-NH-SO 2 -NH 2 , -CO-O-CH 2 -COOH, -CO-O-CH 2 -CH 2 -N(CH 3 ) 2 , -CO-O-CH 2 -CO-N(CH 3 ) 2 , -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl, (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl-O-CO-, -CH 2 -COOH, -CH 2 -CO-O-ethyl, -CH 2 -CH 2 -COOH, -CF 2 -COOH, -CH=CH-COOH, -NH-CO-COOH, -CO-COOH, -O-CH 2 -CH 2 -COOH, -O-CH(CH 3 )-COOH, -NH-CH(CH 3 )-COOH, -NH-CH 2 -CO-O-CH 3 , -COO-phenyl, 1-carboxy-cyclopropan-1-yl, 1-carboxy-cyclopentan-1-yl]; -CO-CH 2 -CN; -CO-CH 2 -OH; -CO-H; 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl, 1-hydroxy-ethyl); dihydroxy-(C 2-4 )alkyl (especially 1,2-dihydroxyethyl); hydroxy-(C 2-4 )alkoxy (especially 2-hydroxy-ethoxy); (C 1-4 )alkoxy-(C 2-4 )alkoxy (especially 2-methoxy-ethoxy); -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1; and wherein ▪ R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl, -or -SO 2 -(C 1-4 )alkyl (wherein preferably at least one of R N1< and R N2< represents hydrogen); ▪ or R N1< independently represents hydrogen or (C 1-4 )alkyl, and R N2< independently represents -CO-H, -CO-(C 1-3 )alkyl, -CO-(C 1-3 )alkylene-OH, or -CO-O-(C 1-3 )alkyl; ▪ or R N1< and R N2< together with the nitrogen to which they are attached form a 4-, 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or -CH 2 -NH-SO 2 -CH 3 ; or -NH-CO-H, -N(C 2 H 5 )-CO-H, -NH-CO-C 2 H 5 , -NH-CO-CH 2 -CH 2 -OH, -NH-CO-O-CH 3 , -N(CH 3 )-CO-O-CH 3 ; or pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, morpholin-4-yl, azetidin-1-yl, or piperidin-1-yl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, hydroxy-(C 2-4 )alkoxy, benzyloxy, or hydroxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -N(CH 3 ) 2 , -CO-NH-O-benzyl, or -CO-N(CH 3 ) 2 , -CO-NH-isopropyl, or -CO-NH-OH); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl; (especially such group is -NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ) -SO 2 -R S1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl; (especially such group is -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 ) 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (encompassing its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl), or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (encompassing its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl); benzooxazol-2-yl; or -(CH 2 ) p -HET , wherein p represents the integer 0 or 1 (especially 0); and wherein HET represents a 5-or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or disubstituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C 3-5 )cycloalkyl (especially cyclopropyl), or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, dimethylamino); (especially such group -(CH 2 ) p -HET is 1H-tetrazol-5-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 3-methyl-pyrazol-1-yl, 1-methyl-1H-pyrazol-3-yl, 5-methyl-1H-pyrazol-3-yl, 3,5-dimethyl-pyrazol-1-yl, 4-carboxy-1H-pyrazol-3-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 3-methyl-3H-imidazol-4-yl, 2-methyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-2-yl, [1,2,4]oxadiazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, 3-methyl-[1,2,4]oxadiazol-5-yl, 5-methyl-[1,3,4]oxadiazol-2-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, 4-methyl-thiazol-2-yl, 2-methyl-thiazol-4-yl, 2-amino-5-methyl-thiazol-4-yl, 4,5-dimethyl-thiazol-2-yl, 4-carboxy-thiazol-2-yl, 2-carboxy-thiazol-4-yl, 2-hydroxy-thiazol-4-yl, 2-amino-2-oxoethyl)thiazol-4-yl, isoxazol-3-yl, isoxazol-5-yl, 3-amino-isoxazol-5-yl, 3-hydroxy-isoxazol-5-yl, 3-methyl-isoxazol-5-yl, 4-methyl-isoxazol-5-yl, 4-carboxy-3-methyl-isoxazol-5-yl, oxazol-5-yl, 2-amino-oxazol-5-yl, 2-methyl-oxazol-5-yl, 2-(2-carboxyethyl)-oxazol-5-yl, 2-(2-carboxyethyl)-4-methyl-oxazol-5-yl, 5-amino-[1,3,4]thiadiazol-2-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl, 4H-[1,2,4]triazol-3-yl, 1H-[1,2,4]triazol-1-yl, 2-methyl-2H-[1,2,4]triazol-3-yl, pyridin-2-yl, 4-fluoro-pyridin-2-yl, pyrimidin-2-yl, 5-fluoro-pyrimidin-2-yl, 5-methoxy-pyrimidin-2-yl, 4-methoxy-pyrimidin-2-yl, 6-methoxy-pyrimidin-4-yl, 6-dimethylamino-pyrimidin-4-yl, pyrazin-2-yl, 6-methoxy-pyrazin-2-yl, 6-methoxy-pyridazin-3-yl, pyrazol-1-yl-methyl, 1H-imidazol-4-yl, 3H-[1,2,3]triazol-4-yl, 5-methyl-1H-imidazol-4-yl, 1,2-dimethyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl, 2-cyclopropyl-1H-imidazol-4-yl, 2-cyclopropyl-1-methyl-1H-imidazol-4-yl, oxazol-2-yl, 4,5-dimethyl-oxazol-2-yl, or pyridin-2-yl); and the remaining one or two of said substituents (if present) is / are independently selected from (C 1-6 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; nitro; -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 0); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl (especially 2,2,2-trifluoro-ethyl), -or -SO 2 -(C 1-4 )alkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl); -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; or phenyl-oxy, wherein the phenyl is optionally mono-substituted with halogen (especially 4-fluorophenoxy); or Ar 1< represents 8- to 10-membered bicyclic heteroaryl (especially indazolyl, benzoimidazolyl, indolyl, benzotriazolyl, benzooxazolyl, quinoxalinyl, isoquinolinyl, quinolinyl, pyrrolopyridinyl, or imidazopyridinyl); wherein said 8- to 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, di- or tri-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl); (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); halogen; and -(C 0-3 )alkylene-COOR O2< wherein R O2< representshydrogen or (C 1-4 )alkyl (especially methyl); (especially such 8- to 10-membered bicyclic heteroaryl 1H-indazol-6-yl, 1-methyl-1H-indazol-6-yl, 3-methyl-1H-indazol-6-yl, 3-carboxy-1H-indazol-6-yl, 1H-benzoimidazol-5-yl, 2-methyl-1H-benzoimidazol-5-yl, 2-trifluoromethyl-1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1-methyl-1H-indol-5-yl, 2-carboxy-1H-indol-5-yl, 7-carboxy-1H-indol-4-yl, 7-carboxy-1-methyl-1H-indol-4-yl, 1H-benzotriazol-5-yl, 2-methyl-benzooxazol-5-yl, 2-methyl-benzooxazol-6-yl, quinoxalin-6-yl, isoquinolin-7-yl, quinolin-6-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indazol-5-yl, 1H-pyrrolo[2,3-c]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, 1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl, imidazo[1,2-a]pyridin-6-yl, 3-methoxy-1H-indazol-6-yl, 6-methoxy-1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1H-indol-2-yl; preferably such 8- to 10-membered bicyclic heteroaryl is 1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1H-indol-2-yl, 1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1H-indol-2-yl); or Ar 1< represents 8- to 10-membered partially aromatic fused bicyclic heterocyclyl comprising one to four heteroatoms independently selected from nitrogen, oxygen and sulfur (especially 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-1H-indazolyl, 2,3-dihydro-1H-benzo[d]imidazolyl, 2,3-dihydrobenzo[d]isoxazolyl, 2,3-dihydro-isoindolyl, 2,3-dihydro-benzooxazolyl, 1,2,3,4-tetrahydro-quinazolinyl, 1,2,3,4-tetrahydro-isoquinolinyl, or 1,2,3,4-tetrahydro-phthalazinyl); wherein said 8- to 10-membered heterocyclyl is linked to the rest of the molecule at the aromatic ring moiety; wherein said 8- to 10-membered heterocyclyl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo, (C 1-6 )alkyl (especially methyl, ethyl, propyl, butyl, isobutyl), and -(C 0-3 )alkylene-COOR O3< wherein R O3< representshydrogen or (C 1-3 )alkyl; (especially such 8- to 10-membered partially aromatic fused bicyclic heterocyclyl is 2,3-dihydro-benzofuran-5-yl, 2,3-dihydro-1H-indol-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, 3-oxo-2,3-dihydro-1H-indazol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl, 3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl, 2-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 1-(carboxymethyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl, or 1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl; preferably such group (Ar-III) is 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, or 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl). 8) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents a phenyl group of the structure (Ar-I): wherein R 5< represents; (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl, wherein said (C 1-3 )fluoroalkyl is optionally substituted with hydroxy (especially 2,2,2-trifluoro-1-hydroxy-ethyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is optionally mono-substituted with amino (especially 1-amino-cyclopropyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is optionally mono-substituted with -COOH (especially 1-carboxy-cyclopropyl, 1-carboxy-cyclopentyl); hydroxy; -X 1< -CO-R O1< , wherein ▪ X 1< represents a direct bond, -O-CH 2 -*, -NH-CH 2 -*, -S-CH 2 -*, or (C 1-3 )alkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O 1< group; and ▪ R O 1< represents -OH, -O-(C 1-4 )alkyl (especially ethoxy), or -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 3-6 )cycloalkyl-(C 1-3 )alkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 1-3 )fluoroalkyl, phenyl, or -NH 2 ; [wherein in a sub-embodiment such group -X 1< -CO-R O1< represents especially -COOH, -CO-(C 1-4 )alkoxy, -O-CH 2 -COOH, -NH-CH 2 -COOH, -CO-NH-SO 2 -(C 1-4 )alkyl, -CO-NH-SO 2 -(C 3-6 )cycloalkyl, or -CO-NH-SO 2 -phenyl; in particular, such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, - NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, or -CO-NH-SO 2 -phenyl]; -CO-CH 2 -CN; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl); -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 1); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, or (C 3-6 )cycloalkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, 2-oxopyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, or morpholin-4-yl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, hydroxy-(C 2-4 )alkoxy, or benzyloxy; (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , - CO-NH-C 2 H 4 -N(CH 3 ) 2 , -CO-NH-O-benzyl) -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (especially such group represents-NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ); -SO 2 -R S1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl (especially such group represents -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 ); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl, or -(CH 2 ) p -HET , wherein p represents the integer 0 or 1 (especially 0); and wherein HET represents a 5-or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or disubstituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, or - NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, dimethylamino); (especially such group -(CH 2 ) p -HET is 1 H-tetrazol-5-yl, 1 H-pyrazol-1-yl, 1H-pyrazol-3-yl, 3-methyl-pyrazol-1-yl, 1-methyl-1 H-pyrazol-3-yl, 5-methyl-1H-pyrazol-3-yl, 3,5-dimethyl-pyrazol-1-yl, 4-carboxy-1H-pyrazol-3-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 3-methyl-3H-imidazol-4-yl, 2-methyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-2-yl, [1,2,4]oxadiazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, 3-methyl-[1,2,4]oxadiazol-5-yl, 5-methyl-[1,3,4]oxadiazol-2-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, 4-methyl-thiazol-2-yl, 2-methyl-thiazol-4-yl, 2-amino-5-methyl-thiazol-4-yl, 4,5-dimethyl-thiazol-2-yl, 4-carboxy-thiazol-2-yl, 2-carboxy-thiazol-4-yl, 2-hydroxy-thiazol-4-yl, 2-amino-2-oxoethyl)thiazol-4-yl, isoxazol-3-yl, isoxazol-5-yl, 3-amino-isoxazol-5-yl, 3-hydroxy-isoxazol-5-yl, 3-methyl-isoxazol-5-yl, 4-methyl-isoxazol-5-yl, 4-carboxy-3-methyl-isoxazol-5-yl, oxazol-5-yl, 2-amino-oxazol-5-yl, 2-methyl-oxazol-5-yl, 2-(2-carboxyethyl)-oxazol-5-yl, 2-(2-carboxyethyl)-4-methyl-oxazol-5-yl, 5-amino-[1,3,4]thiadiazol-2-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl, 4H-[1,2,4]triazol-3-yl, 1H-[1,2,4]triazol-1-yl, 2-methyl-2H-[1,2,4]triazol-3-yl, pyridin-2-yl, 4-fluoro-pyridin-2-yl, pyrimidin-2-yl, 5-fluoro-pyrimidin-2-yl, 5-methoxy-pyrimidin-2-yl, 4-methoxy-pyrimidin-2-yl, 6-methoxy-pyrimidin-4-yl, 6-dimethylamino-pyrimidin-4-yl, pyrazin-2-yl, 6-methoxy-pyrazin-2-yl, 6-methoxy-pyridazin-3-yl, or pyrazol-1-yl-methyl); and (R 4< ) n represents one or two optional substituents (i.e. n represents the integer 0, 1, or 2) independently selected from (C 1-6 )alkyl (especially methyl, ethyl, propyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; nitro; -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 0); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl (especially 2,2,2-trifluoro-ethyl), -or -SO 2 -(C 1-4 )alkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl); -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; or phenyl-oxy, wherein the phenyl is optionally mono-substituted with halogen (especially 4-fluorophenoxy); or Ar 1< represents a 5-membered heteroaryl group of the structure (Ar-II): wherein in (Ar-II) the ring A represents a 5-membered heteroaryl ring (wherein it is well understood that in (Ar-II) the substituent R 7< is attached in meta-position with respect to the point of attachment of the rest of the molecule) (notably a thiophenyl or a thiazolyl ring; especially thiophen-2-yl wherein R 7< is attached in position 5, or thiazol-2-yl wherein R 7< is attached in position 5); wherein • R 7< represents (C 1-4 )alkoxy (especially methoxy); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is optionally mono-substituted with amino (especially 1-amino-cyclopropyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is optionally mono-substituted with -COOH (especially 1-carboxy-cyclopropyl, 1-carboxy-cyclopentyl); hydroxy; -X 1< -CO-R O1< , wherein ▪ X 1< represents a direct bond, -O-CH 2 -*, -NH-CH 2 -*, -S-CH 2 -*, or (C 1-3 )alkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O 1< group; and ▪ R O 1< represents -OH, -O-(C 1-4 )alkyl (especially ethoxy), or -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 3-6 )cycloalkyl-(C 1-3 )alkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom; (C 1-3 )fluoroalkyl, phenyl, or -NH 2 ; [wherein in a sub-embodiment such group -X 1< -CO-R O1< represents especially -COOH, -CO-(C 1-4 )alkoxy, -O-CH 2 -COOH, -NH-CH 2 -COOH, -CO-NH-SO 2 -(C 1-4 )alkyl, -CO-NH-SO 2 -(C 3-6 )cycloalkyl, or -CO-NH-SO 2 -phenyl; in particular, such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, - NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, or -CO-NH-SO 2 -phenyl]; -CO-CH 2 -CN; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl); -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 1); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, or (C 3-6 )cycloalkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, 2-oxopyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, or morpholin-4-yl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, or hydroxy-(C 2-4 )alkoxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -N(CH 3 ) 2 ); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (especially such group is -NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ); -SO 2 -R S1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl (especially such group is -SO 2 -CH 3 , -SO 2 -NH 2 , - SO 2 -OH, -SO 2 -NH-CH 3 ); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl; or 5- or 6-membered heteroaryl (notably 5-membered heteroaryl, especially 1H-tetrazol-5-yl), wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), - COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, dimethylamino); • and (R 6< ) n represents one optional substituent (i.e. n represents the integer 0, or 1) independently selected from (C 1-6 )alkyl (especially methyl, ethyl, propyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 0); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl (especially 2,2,2-trifluoro-ethyl), -or -SO 2 -(C 1-4 )alkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl); and -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; or Ar 1< represents 9- or 10-membered bicyclic heteroaryl (especially indazolyl, benzoimidazolyl, indolyl, benzotriazolyl, benzooxazolyl, quinoxalinyl, isoquinolinyl, quinolinyl; or pyrrolopyridinyl, or imidazopyridinyl); wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl); (C 1-3 )fiuoroalkyl (especially trifluoromethyl); or -COOH (especially such group is 1H-indazol-6-yl, 1-methyl-1H-indazol-6-yl, 3-methyl-1H-indazol-6-yl, 3-carboxy-1H-indazol-6-yl, 1H-benzoimidazol-5-yl, 2-methyl-1H-benzoimidazol-5-yl, 2-trifluoromethyl-1H-benzoimidazol-5-yl, H-indol-6-yl, 1H-indol-5-yl, 1-methyl-1H-indol-5-yl, 2-carboxy-1H-indol-5-yl, 7-carboxy-1H-indol-4-yl, 7-carboxy-1-methyl-1H-indol-4-yl, 1H-benzotriazol-5-yl, 2-methyl-benzooxazol-5-yl, 2-methyl-benzooxazol-6-yl, quinoxalin-6-yl, isoquinolin-7-yl, quinolin-6-yl); or Ar 1< represents a group of the structure (Ar-III): wherein ring (B) represents a non-aromatic 5- or 6-membered ring fused to the phenyl group, wherein ring (B) comprises one or two heteroatoms independently selected from nitrogen and oxygen (notably such group (Ar-III) is 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-1H-indazolyl, 2,3-dihydro-1H-benzo[d]imidazolyl, 2,3-dihydrobenzo[d]isoxazolyl, 2,3-dihydro-isoindolyl; or 2,3-dihydro-benzooxazol-6-yl, or 2,3-dihydro-benzooxazol-5-yl, or 1,2,3,4-tetrahydro-quinazolin-6-yl, or 1,2,3,4-tetrahydro-quinazolin-7-yl, or 1,2,3,4-tetrahydro-isoquinolin-6-yl, or 1,2,3,4-tetrahydro-phthalazin-6-yl); wherein said ring (B) independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo and (C 1-6 )alkyl (especially methyl, ethyl, propyl, butyl, isobutyl) (especially such group (Ar-III) is 2,3-dihydro-benzofuran-5-yl, 2,3-dihydro-1H-indol-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, 3-oxo-2,3-dihydro-1H-indazol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl, 3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl, or 2-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl). 9) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents a phenyl group of the structure (Ar-I): wherein R 5< represents; (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl, wherein said (C 1-3 )fluoroalkyl is optionally substituted with hydroxy (especially 2,2,2-trifluoro-1-hydroxy-ethyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is unsubstituted or mono-substituted with amino (especially 1-amino-cyclopropyl); (C 4-6 )cycloalkyl containing a ring oxygen atom, wherein said (C 4-6 )cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy (especially 3-fluoro-oxetan-3-yl, 3-hydroxy-oxetan-3-yl, 3-methoxy-oxetan-3-yl); hydroxy; -B(OH) 2 ; 2,2,2-trifluoro-1,1-dihydroxy-ethyl; -X 1< -CO-R O1< , wherein X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH(CH 3 )-*, -O-CH 2 -CH 2 -*), -NH-(C 1-3 )alkylene-* (especially -NH-CH 2 -*, -NH-CH(CH 3 )-*), -S-CH 2 -*, -CF 2 -, -CH=CH-, -C≡C-, -NH-CO-*, -CO-, or (C 3-5 )cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O 1< group; and R O 1< represents ▪ -OH; ▪ -O-(C 1-4 )alkyl (especially ethoxy, methoxy); ▪ -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 3-6 )cycloalkyl-(C 1-3 )alkylene wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 1-3 )fluoroalkyl, phenyl, or -NH 2 ; ▪ -O-phenyl; ▪ -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1-4 )alkoxy, or -N[(C 1-4 )alkyl] 2 ; ▪ -O-CH 2 -O-CO-R O5< , wherein R O5< represents (C 1-4 )alkyl or (C 1-4 )alkoxy; or ▪ -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 (especially -O-CH 2 -CH 2 -N(CH 3 ) 2 ); ▪ (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; [wherein in particular such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, - NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-NH-SO 2 -phenyl, -CO-O-CH 3 , -CO-NH-SO 2 -ethyl, -CO-NH-SO 2 -NH 2 , -CO-O-CH 2 -COOH, -CO-O-CH 2 -CH 2 -N(CH 3 ) 2 , -CO-O-CH 2 -CO-N(CH 3 ) 2 , -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl, (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl-O-CO-, -CH 2 -COOH, -CH 2 -CO-O-ethyl, -CH 2 -CH 2 -COOH, - CF 2 -COOH, -CH=CH-COOH, -NH-CO-COOH, -CO-COOH, -O-CH 2 -CH 2 -COOH, -O-CH(CH 3 )-COOH, -NH-CH(CH 3 )-COOH, -NH-CH 2 -CO-O-CH 3 , -COO-phenyl, 1-carboxy-cyclopropan-1-yl, 1-carboxy-cyclopentan-1-yl]; -CO-CH 2 -CN; -CO-CH 2 -OH; -CO-H; 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl, 1-hydroxy-ethyl); dihydroxy-(C 2-4 )alkyl (especially 1,2-dihydroxyethyl); hydroxy-(C 2-4 )alkoxy (especially 2-hydroxy-ethoxy); (C 1-4 )alkoxy-(C 2-4 )alkoxy (especially 2-methoxy-ethoxy); -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1; and wherein ▪ R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl, -or -SO 2 -(C 1-4 )alkyl (wherein preferably at least one of R N1< and R N2< represents hydrogen); ▪ or R N1< independently represents hydrogen or (C 1-4 )alkyl, and R N2< independently represents -CO-H, -CO-(C 1-3 )alkyl, -CO-(C 1-3 )alkylene-OH, or -CO-O-(C 1-3 )alkyl; ▪ or R N1< and R N2< together with the nitrogen to which they are attached form a 4-, 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, amino-methyl, methylamino-methyl, isobutylamino-methyl, cyclopropylamino-methyl, cyclobutylamino-methyl, (2-methoxyethyl)amino-methyl, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or -CH 2 -NH-SO 2 -CH 3 ; or -NH-CO-H, -N(C 2 H 5 )-CO-H, -NH-CO-C 2 H 5 , -NH-CO-CH 2 -CH 2 -OH, -NH-CO-O-CH 3 , -N(CH 3 )-CO-O-CH 3 ; or pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, morpholin-4-yl, azetidin-1-yl, or piperidin-1-yl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, hydroxy-(C 2-4 )alkoxy, benzyloxy, or hydroxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -N(CH 3 ) 2 , -CO-NH-O-benzyl, or -CO-N(CH 3 ) 2 , -CO-NH-isopropyl, or -CO-NH-OH); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (especially such group represents -NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ); -SO 2 -R S1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl (especially such group represents -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 ); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (encompassing its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl), or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (encompassing its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl); benzooxazol-2-yl; or -(CH 2 ) p -HET , wherein p represents the integer 0 or 1 (especially 0); and wherein HET represents a 5-or 6-membered heteroaryl (especially oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, pyridinyl, pyrimidinyl, pyridazinyl, or pyrazinyl), wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C 3-5 )cycloalkyl (especially cyclopropyl), or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, methylamino, dimethylamino); (especially such group -(CH 2 ) p -HET is 1H-tetrazol-5-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 3-methyl-pyrazol-1-yl, 1-methyl-1H-pyrazol-3-yl, 5-methyl-1H-pyrazol-3-yl, 3,5-dimethyl-pyrazol-1-yl, 4-carboxy-1H-pyrazol-3-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 3-methyl-3H-imidazol-4-yl, 2-methyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-2-yl, [1,2,4]oxadiazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, 3-methyl-[1,2,4]oxadiazol-5-yl, 5-methyl-[1,3,4]oxadiazol-2-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, 4-methyl-thiazol-2-yl, 2-methyl-thiazol-4-yl, 2-amino-5-methyl-thiazol-4-yl, 4,5-dimethyl-thiazol-2-yl, 4-carboxy-thiazol-2-yl, 2-carboxy-thiazol-4-yl, 2-hydroxy-thiazol-4-yl, 2-amino-2-oxoethyl)thiazol-4-yl, isoxazol-3-yl, isoxazol-5-yl, 3-amino-isoxazol-5-yl, 3-hydroxy-isoxazol-5-yl, 3-methyl-isoxazol-5-yl, 4-methyl-isoxazol-5-yl, 4-carboxy-3-methyl-isoxazol-5-yl, oxazol-5-yl, 2-amino-oxazol-5-yl, 2-methyl-oxazol-5-yl, 2-(2-carboxyethyl)-oxazol-5-yl, 2-(2-carboxyethyl)-4-methyl-oxazol-5-yl, 5-amino-[1,3,4]thiadiazol-2-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl, 4H-[1,2,4]triazol-3-yl, 1H-[1,2,4]triazol-1-yl, 2-methyl-2H-[1,2,4]triazol-3-yl, pyridin-2-yl, 4-fluoro-pyridin-2-yl, pyrimidin-2-yl, 5-fluoro-pyrimidin-2-yl, 5-methoxy-pyrimidin-2-yl, 4-methoxy-pyrimidin-2-yl, 6-methoxy-pyrimidin-4-yl, 6-dimethylamino-pyrimidin-4-yl, pyrazin-2-yl, 6-methoxy-pyrazin-2-yl, 6-methoxy-pyridazin-3-yl, pyrazol-1-yl-methyl, 1H-imidazol-4-yl, 3H-[1,2,3]triazol-4-yl, 5-methyl-1H-imidazol-4-yl, 1,2-dimethyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl, 2-cyclopropyl-1H-imidazol-4-yl, 2-cyclopropyl-1-methyl-1H-imidazol-4-yl, oxazol-2-yl, 4,5-dimethyloxazol-2-yl, or pyridin-2-yl); and (R 4< ) n represents one or two optional substituents (i.e. n represents the integer 0, 1, or 2) independently selected from (C 1-6 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; nitro; -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 0); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl (especially 2,2,2-trifluoro-ethyl), -or -SO 2 -(C 1-4 )alkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl); -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; or > phenyl-oxy, wherein the phenyl is optionally mono-substituted with halogen (especially 4-fluorophenoxy); [wherein especially (R 4< ) n is absent, or (R 4< ) n represents one or two substituents, wherein one of said substituents is as defined above, and the other, if present, is fluoro or chloro]; or R 5< represents hydrogen, and (R 4< ) n represents one or two substituents (i.e. n represents the integer 1 or 2), wherein one of said substituents is selected from 1H-pyrazol-1-yl, and -X 1< -COOH, wherein X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), or -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, - O-CH 2 -CH 2 -*), wherein the asterisks indicate the bond that is linked to the -COOH group [wherein in particular such group -X 1< -COOH represents -COOH, -CH 2 -COOH, -CH 2 -CH 2 -COOH, -O-CH 2 -CH 2 -COOH]; and the other of said substituents, if present, is selected from (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy); and -S-(C 1-4 )alkyl (especially -S-methyl, -S-ethyl, -S-n-propyl); or Ar 1< represents a 5-membered heteroaryl group of the structure (Ar-II): wherein in (Ar-II) the ring A represents a 5-membered heteroaryl ring (wherein it is well understood that in (Ar-II) the substituent R 7< is attached in meta-position with respect to the point of attachment of the rest of the molecule) (notably a thiophenyl or a thiazolyl ring; especially thiophen-2-yl wherein R 7< is attached in position 5, or thiophen-2-yl wherein R 7< is attached in position 4; or thiazol-2-yl wherein R 7< is attached in position 5); wherein R 7< represents (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl, wherein said (C 1-3 )fluoroalkyl is optionally substituted with hydroxy (especially 2,2,2-trifluoro-1-hydroxy-ethyl); (C 3-6 )cycloalkyl, wherein said (C 3-6 )cycloalkyl is unsubstituted or mono-substituted with amino (especially 1-amino-cyclopropyl); (C 4-6 )cycloalkyl containing a ring oxygen atom, wherein said (C 4-6 )cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy (especially 3-fluoro-oxetan-3-yl, 3-hydroxy-oxetan-3-yl, 3-methoxy-oxetan-3-yl); hydroxy; 2,2,2-trifluoro-1,1-dihydroxy-ethyl; -X 1< -CO-R O1< , wherein X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH(CH 3 )-*, -O-CH 2 -CH 2 -*), -NH-(C 1-3 )alkylene-* (especially -NH-CH 2 -*, -NH-CH(CH 3 )-*), -S-CH 2 -*, -CF 2 -, -CH=CH-, -C≡C-, -NH-CO-*, -CO-, or (C 3-5 )cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O1< group; and R O1< represents ▪ -OH; ▪ -O-(C 1-4 )alkyl (especially ethoxy, methoxy); ▪ -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 3-6 )cycloalkyl-(C 1-3 )alkylene wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 1-3 )fluoroalkyl, phenyl, or -NH 2 ; ▪ -O-phenyl; ▪ -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1-4 )alkoxy, or -N[(C 1-4 )alkyl] 2 ; ▪ -O-CH 2 -O-CO-R O5< , wherein R O5< represents (C 1-4 )alkyl or (C 1-4 )alkoxy; or ▪ -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 (especially -O-CH 2 -CH 2 -N(CH 3 ) 2 ); ▪ (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; [wherein in particular, such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, - NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-NH-SO 2 -phenyl, -CO-O-CH 3 , -CO-NH-SO 2 -ethyl, -CO-NH-SO 2 -NH 2 , -CO-O-CH 2 -COOH, -CO-O-CH 2 -CH 2 -N(CH 3 ) 2 , -CO-O-CH 2 -CO-N(CH 3 ) 2 , -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl, (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl-O-CO-, -CH 2 -COOH, -CH 2 -CO-O-ethyl, -CH 2 -CH 2 -COOH, - CF 2 -COOH, -CH=CH-COOH, -NH-CO-COOH, -CO-COOH, -O-CH 2 -CH 2 -COOH, -O-CH(CH 3 )-COOH, -NH-CH(CH 3 )-COOH, -NH-CH 2 -CO-O-CH 3 , -COO-phenyl, 1-carboxy-cyclopropan-1-yl, 1-carboxy-cyclopentan-1-yl]; -CO-CH 2 -CN; -CO-CH 2 -OH; -CO-H; 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl, 1-hydroxy-ethyl); dihydroxy-(C 2-4 )alkyl (especially 1,2-dihydroxyethyl); hydroxy-(C 2-4 )alkoxy (especially 2-hydroxy-ethoxy); (C 1-4 )alkoxy-(C 2-4 )alkoxy (especially 2-methoxy-ethoxy); -NR N1< R N2< , wherein ▪ R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl, -or -SO 2 -(C 1-4 )alkyl (wherein preferably at least one of R N1< and R N2< represents hydrogen); ▪ or R N1< independently represents hydrogen or (C 1-4 )alkyl, and R N2< independently represents -CO-H, -CO-(C 1-3 )alkyl, -CO-(C 1-3 )alkylene-OH, or -CO-O-(C 1-3 )alkyl; ▪ or R N1< and R N2< together with the nitrogen to which they are attached form a 4-, 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or -CH 2 -NH-SO 2 -methyl; or -NH-CO-H, -N(C 2 H 5 )-CO-H, -NH-CO-C 2 H 5 , -NH-CO-CH 2 -CH 2 -OH, -NH-CO-O-CH 3 , -N(CH 3 )-CO-O-CH 3 ; or pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 1,1-dioxo-isothiazolidin-2-yl, morpholin-4-yl, azetidin-1-yl, or piperidin-1-yl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, hydroxy-(C 2-4 )alkoxy, benzyloxy, or hydroxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -N(CH 3 ) 2 , -CO-NH-O-benzyl, or -CO-N(CH 3 ) 2 , -CO-NH-isopropyl, or -CO-NH-OH); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (especially such group represents-NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ); -SO 2 -R S1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl (especially such group represents -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 ); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (encompassing its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl), or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (encompassing its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl); HET, wherein HET represents a 5- or 6-membered heteroaryl (especially oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, pyridinyl, pyrimidinyl, pyridazinyl, or pyrazinyl, notably tetrazolyl, or isoxazolyl), wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C 3-5 )cycloalkyl (especially cyclopropyl), or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, dimethylamino); (especially such group HET is 1H-tetrazol-5-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 3-methyl-pyrazol-1-yl, 1-methyl-1H-pyrazol-3-yl, 5-methyl-1H-pyrazol-3-yl, 3,5-dimethyl-pyrazol-1-yl, 4-carboxy-1H-pyrazol-3-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 3-methyl-3H-imidazol-4-yl, 2-methyl-1H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-2-yl, [1,2,4]oxadiazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, 3-methyl-[1,2,4]oxadiazol-5-yl, 5-methyl-[1,3,4]oxadiazol-2-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, 4-methyl-thiazol-2-yl, 2-methyl-thiazol-4-yl, 2-amino-5-methyl-thiazol-4-yl, 4,5-dimethyl-thiazol-2-yl, 4-carboxy-thiazol-2-yl, 2-carboxy-thiazol-4-yl, 2-hydroxy-thiazol-4-yl, 2-amino-2-oxoethyl)thiazol-4-yl, isoxazol-3-yl, isoxazol-5-yl, 3-amino-isoxazol-5-yl, 3-hydroxy-isoxazol-5-yl, 3-methyl-isoxazol-5-yl, 4-methyl-isoxazol-5-yl, 4-carboxy-3-methyl-isoxazol-5-yl, oxazol-5-yl, 2-amino-oxazol-5-yl, 2-methyl-oxazol-5-yl, 2-(2-carboxyethyl)-oxazol-5-yl, 2-(2-carboxyethyl)-4-methyl-oxazol-5-yl, 5-amino-[1,3,4]thiadiazol-2-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl, 4H-[1,2,4]triazol-3-yl, 1H-[1,2,4]triazol-1-yl, 2-methyl-2H-[1,2,4]triazol-3-yl, pyridin-2-yl, 4-fluoro-pyridin-2-yl, pyrimidin-2-yl, 5-fluoro-pyrimidin-2-yl, 5-methoxy-pyrimidin-2-yl, 4-methoxy-pyrimidin-2-yl, 6-methoxy-pyrimidin-4-yl, 6-dimethylamino-pyrimidin-4-yl, pyrazin-2-yl, 6-methoxy-pyrazin-2-yl, 6-methoxy-pyridazin-3-yl, pyrazol-1-yl-methyl, 1H-imidazol-4-yl, 3H-[1,2,3]triazol-4-yl, 5-methyl-1H-imidazol-4-yl, 1,2-dimethyl-1 H-imidazol-4-yl, 1,5-dimethyl-1 H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl, 2-cyclopropyl-1H-imidazol-4-yl, 2-cyclopropyl-1-methyl-1H-imidazol-4-yl, oxazol-2-yl, 4,5-dimethyl-oxazol-2-yl, or pyridin-2-yl; notably HET is 1H-tetrazol-5-yl or 3-hydroxy-isoxazol-5-yl); and (R 6< ) n represents one optional substituent (i.e. n represents the integer 0, or 1) independently selected from (C 1-6 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; pyridinyl; -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 0); and wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy-(C 2-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-3 )fluoroalkyl (especially 2,2,2-trifluoro-ethyl), -or -SO 2 -(C 1-4 )alkyl; or R N1< and R N2< together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, -NH-SO 2 -methyl, -NH-SO 2 -ethyl, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl); and -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; [wherein, if present, such substituent R 6< is especially attached in the other meta-position with respect to the point of attachment of the rest of the molecule, i.e. especially ring A represents thiophen-2-yl wherein R 7< is attached in position 5 and R 6< is attached in position 4, or thiophen-2-yl wherein R 7< is attached in position 4 and R 6< is attached in position 5; or thiazol-2-yl wherein R 7< is attached in position 5 and R 6< is attached in position 4)]; or Ar 1< represents 9- or 10-membered bicyclic heteroaryl (especially indazolyl, benzoimidazolyl, indolyl, benzotriazolyl, benzooxazolyl, quinoxalinyl, isoquinolinyl, quinolinyl, pyrrolopyridinyl, or imidazopyridinyl); wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl); (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially trifluoromethoxy); halogen; cyano; hydroxy, or -(C 0-3 )alkylene-COOR O2< wherein R O2< representshydrogen or (C 1-4 )alkyl (especially methyl); (especially such 9- to 10-membered bicyclic heteroaryl is 1H-indazol-6-yl, 1-methyl-1H-indazol-6-yl, 3-methyl-1H-indazol-6-yl, 3-carboxy-1H-indazol-6-yl, 1H-benzoimidazol-5-yl, 2-methyl-1H-benzoimidazol-5-yl, 2-trifluoromethyl-1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1-methyl-1H-indol-5-yl, 2-carboxy-1H-indol-5-yl, 7-carboxy-1H-indol-4-yl, 7-carboxy-1-methyl-1H-indol-4-yl, 1H-benzotriazol-5-yl, 2-methyl-benzooxazol-5-yl, 2-methyl-benzooxazol-6-yl, quinoxalin-6-yl, isoquinolin-7-yl, quinolin-6-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indazol-5-yl, 1H-pyrrolo[2,3-c]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, 1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl, imidazo[1,2-a]pyridin-6-yl, 3-methoxy-1H-indazol-6-yl, 6-methoxy-1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1H-indol-2-yl; preferably such 9- to 10-membered bicyclic heteroaryl is 1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1H-indol-2-yl, 1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1 H-indol-2-yl); or Ar 1< represents a group of the structure (Ar-III): wherein ring (B) represents a non-aromatic 5- or 6-membered ring fused to the phenyl group, wherein ring (B) comprises one or two heteroatoms independently selected from nitrogen and oxygen (notably such group (Ar-III) is 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-1H-indazolyl, 2,3-dihydro-1H-benzo[d]imidazolyl, 2,3-dihydrobenzo[d]isoxazolyl, 2,3-dihydro-isoindolyl, 2,3-dihydro-benzooxazolyl, 1,2,3,4-tetrahydro-quinazolinyl, 1,2,3,4-tetrahydro-isoquinolinyl, or 1,2,3,4-tetrahydro-phthalazinyl); wherein said ring (B) independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo, (C 1-6 )alkyl (especially methyl, ethyl, propyl, butyl, isobutyl) and -(C 0-3 )alkylene-COOR O3< wherein R O3< representshydrogen or (C 1-3 )alkyl (especially such group (Ar-III) is 2,3-dihydro-benzofuran-5-yl, 2,3-dihydro-1H-indol-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, 3-oxo-2,3-dihydro-1H-indazol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-2,3-dihydro-1 H-benzo[d]imidazol-5-yl, 3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl, 2-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 1-(carboxymethyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl, or 1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl; preferably such group (Ar-III) is 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, or 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl). 10) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents a phenyl group of the structure (Ar-IV): wherein R p< represents; hydroxy; -COOH; -CO-CH 2 -CN; -CO-(C 1-4 )alkoxy (especially -CO-O-ethyl); -CO-NH-SO 2 -R S3< wherein R S3< represents R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl; (C 3-6 )cycloalkyl-(C 1-3 )alkyl; (C 1-3 )fluoroalkyl, phenyl, or -NH 2 (especially R S3< represents (C 1-4 )alkyl or cyclopropyl, in particular methyl, isopropyl, or cyclopropyl); -X 1< -CH 2 -COOH, wherein X 1< represents O, or NH (especially -O-CH 2 -COOH, or -NH-CH 2 -COOH); hydroxy-(C 1-4 )alkyl (especially hydroxymethyl); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, or hydroxy-(C 2-4 )alkoxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-C 2 H 4 -N(CH 3 ) 2 ); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (especially such group is -NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ); -SO 2 -R S1< wherein R S1< represents hydroxy, (C 1-4 )alkyl (especially methyl), or -NR N7< R N8< wherein R N7< and R N8< independently represent hydrogen or (C 1-3 )alkyl (especially such group is -SO 2 -CH 3 , -SO 2 -NH 2 , -SO 2 -OH, -SO 2 -NH-CH 3 ); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl; tetrazolyl (especially 1H-tetrazol-5-yl); or 5- or 6-membered heteroaryl selected from oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, or pyrazinyl; wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, dimethylamino); R m1< represents hydrogen; (C 1-6 )alkyl (especially methyl, ethyl, propyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially chloro, or fluoro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; -(CH 2 ) m -NR N1< R N2< , wherein m represents the integer 0 or 1 (especially 0); and wherein R N1< and R N2< independently represent hydrogen, (C 1-3 )alkyl (especially methyl, ethyl), or (C 2-3 )fluoroalkyl (especially 2,2,2-trifluoro-ethyl); or R N1< and R N2< together with the nitrogen to which they are attached form a pyrrolidinyl ring (especially such group -(CH 2 ) m -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, or (2,2,2-trifluoro-ethyl)-amino; or pyrrolidin-1-yl); or -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), or (C 3-6 )cycloalkyl (especially cyclobutyl); and R m2< represents hydrogen; or (C 1-6 )alkyl (especially methyl, ethyl); (C 1-3 )alkoxy (especially methoxy, ethoxy); or halogen (especially chloro, or fluoro); or Ar 1< represents a 5-membered heteroaryl group of the structure (Ar-V): wherein in (Ar-V) the ring A represents a thiophenyl or a thiazolyl ring (especially thiophen-2-yl, or thiazol-2-yl); (wherein it is well understood that in (Ar-V) the substituent R A1< is attached in meta-position with respect to the point of attachment of the rest of the molecule, especially in case the ring A represents a thiophen-2-yl, in position 5 of such thiophen-2-yl) wherein R A1< represents -COOH; tetrazolyl (especially 1H-tetrazol-5-yl); -CO-(C 1-4 )alkoxy (especially -CO-O-ethyl); -CO-NH-SO 2 -R S3< wherein R S3< represents R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl; (C 3-6 )cycloalkyl-(C 1-3 )alkyl; (C 1-3 )fluoroalkyl, phenyl, or -NH 2 (especially R S3< represents (C 1-4 )alkyl or cyclopropyl, in particular methyl, isopropyl, or cyclopropyl); -X 1< -CH 2 -COOH, wherein X 1< represents O, or NH (especially -O-CH 2 -COOH, or -NH-CH 2 -COOH); or -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, or (C 1-3 )alkoxy-(C 2-4 )alkyl; (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 ); and R A2< represents hydrogen; (C 1-6 )alkyl (especially methyl, ethyl); (C 1-4 )alkoxy (especially ethoxy, propoxy, isopropoxy, butoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); halogen (especially fluoro or chloro); or hydroxy; or Ar 1< represents 9- or 10-membered bicyclic heteroaryl selected from 1 H-indol-5-yl, 1H-indol-4-yl, 1H-indol-6-yl, indazol-6-yl, 1H-benzoimidazol-5-yl, 1H-benzotriazol-5-yl, quinoxalin-6-yl, isoquinolin-7-yl, and quinolin-6-yl; wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl) or -COOH (especially such heteroaryl is 1H-indazol-6-yl, 1-methyl-1H-indazol-6-yl, 3-carboxy-1H-indazol-6-yl, 1H-benzoimidazol-5-yl, 2-methyl-1H-benzoimidazol-5-yl, 1H-indol-5-yl, 1-methyl-1H-indol-5-yl, 7-carboxy-1H-indol-4-yl, 1H-benzotriazol-5-yl, quinoxalin-6-yl, isoquinolin-7-yl, or quinolin-6-yl); or Ar 1< represents a group of the structure (Ar-III): wherein ring (B) represents a non-aromatic 5-membered ring fused to the phenyl group, wherein ring (B) comprises one or two nitrogen ring atoms; wherein said ring (B) independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo and (C 1-6 )alkyl (especially methyl, ethyl, propyl, butyl, isobutyl) (especially such group (Ar-III) is 2,3-dihydro-1H-indol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl). 11) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents a phenyl group of the structure (Ar-IV): wherein R p< represents; (C 4-6 )cycloalkyl containing a ring oxygen atom, wherein said (C 4-6 )cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy (especially 3-fluoro-oxetan-3-yl, 3-hydroxy-oxetan-3-yl, 3-methoxy-oxetan-3-yl); hydroxy; -X 1< - CO-R O1< , wherein X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH(CH 3 )-*, -O-CH 2 -CH 2 -*), -NH-(C 1-3 )alkylene-* (especially -NH-CH 2 -*, -NH-CH(CH 3 )-*), -S-CH 2 -*, -CF 2 -, -CH=CH-, -C≡C-, -NH-CO-*, -CO-, or (C 3-5 )cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O1< group; and R O1< represents ▪ -OH; ▪ -O-(C 1-4 )alkyl (especially ethoxy, methoxy); ▪ -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 3-6 )cycloalkyl-(C 1-3 )alkylene wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 1-3 )fluoroalkyl, phenyl, or -NH 2 ; ▪ -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1-4 )alkoxy, or -N[(C 1-4 )alkyl] 2 ; ▪ -O-CH 2 -O-CO-R O5< , wherein R O5< represents (C 1-4 )alkyl or (C 1-4 )alkoxy; or ▪ -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 (especially -O-CH 2 -CH 2 -N(CH 3 ) 2 ); ▪ (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; [wherein in particular such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, - NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-NH-SO 2 -phenyl, -CO-O-CH 3 , -CO-NH-SO 2 -ethyl, -CO-NH-SO 2 -NH 2 , -CO-O-CH 2 -COOH, -CO-O-CH 2 -CH 2 -N(CH 3 ) 2 , -CO-O-CH 2 -CO-N(CH 3 ) 2 , -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl, (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl-O-CO-, -CH 2 -COOH, -CH 2 -CO-O-ethyl, -CH 2 -CH 2 -COOH, - CF 2 -COOH, -CH=CH-COOH, -NH-CO-COOH, -CO-COOH, -O-CH 2 -CH 2 -COOH, -O-CH(CH 3 )-COOH, -NH-CH(CH 3 )-COOH, -NH-CH 2 -CO-O-CH 3 , -COO-phenyl, 1-carboxy-cyclopropan-1-yl, 1-carboxy-cyclopentan-1-yl]; -CO-H; 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; -NR N1< R N2< , wherein ▪ R N1< independently represents hydrogen or (C 1-4 )alkyl, and R N2< independently represents -CO-H, -CO-(C 1-3 )alkyl, or-CO-(C 1-3 )alkylene-OH: (especially such group -(CH 2 ) m -NR N1< R N2< represents-NH-CO-H, -N(C 2 H 5 )-CO-H, -NH-CO-C 2 H 5 , - NH-CO-CH 2 -CH 2 -OH, or -NH-CO-O-CH 3 ); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, or hydroxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , or -CO-N(CH 3 ) 2 , -CO-NH-isopropyl, or - CO-NH-OH); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (especially such group represents-NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (encompassing its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl), or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (encompassing its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl); HET, wherein HET represents a 5- or 6-membered heteroaryl (especially 5-membered heteroaryl selected from oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, and tetrazolyl; or 6-membered heteroaryl selected from pyridinyl, pyrimidinyl, pyridazinyl, and pyrazinyl), wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C 3-5 )cycloalkyl (especially cyclopropyl), or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, methylamino, dimethylamino) (especially the substituents are independently selected from (C 1-3 )alkyl (especially methyl), and hydroxy); (in particular, such group HET is 1H-tetrazol-5-yl, 1 H-pyrazol-1-yl, 1 H-pyrazol-3-yl, 3-methyl-pyrazol-1-yl, 1-methyl-1H-pyrazol-3-yl, 5-methyl-1 H-pyrazol-3-yl, 3,5-dimethyl-pyrazol-1-yl, 4-carboxy-1H-pyrazol-3-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 3-methyl-3H-imidazol-4-yl, 2-methyl-1 H-imidazol-4-yl, 1,5-dimethyl-1H-imidazol-2-yl, [1,2,4]oxadiazol-5-yl, 5-methyl-[1,2,4]oxadiazol-3-yl, 3-methyl-[1,2,4]oxadiazol-5-yl, 5-methyl-[1,3,4]oxadiazol-2-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, 4-methyl-thiazol-2-yl, 2-methyl-thiazol-4-yl, 2-amino-5-methyl-thiazol-4-yl, 4,5-dimethyl-thiazol-2-yl, 4-carboxy-thiazol-2-yl, 2-carboxy-thiazol-4-yl, 2-hydroxy-thiazol-4-yl, 2-amino-2-oxoethyl)thiazol-4-yl, isoxazol-3-yl, isoxazol-5-yl, 3-amino-isoxazol-5-yl, 3-hydroxy-isoxazol-5-yl, 3-methyl-isoxazol-5-yl, 4-methyl-isoxazol-5-yl, 4-carboxy-3-methyl-isoxazol-5-yl, oxazol-5-yl, 2-amino-oxazol-5-yl, 2-methyl-oxazol-5-yl, 2-(2-carboxyethyl)-oxazol-5-yl, 2-(2-carboxyethyl)-4-methyl-oxazol-5-yl, 5-amino-[1,3,4]thiadiazol-2-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl, 4H-[1,2,4]triazol-3-yl, 1H-[1,2,4]triazol-1-yl, 2-methyl-2H-[1,2,4]triazol-3-yl, pyridin-2-yl, 4-fluoro-pyridin-2-yl, pyrimidin-2-yl, 5-fluoro-pyrimidin-2-yl, 5-methoxy-pyrimidin-2-yl, 4-methoxy-pyrimidin-2-yl, 6-methoxy-pyrimidin-4-yl, 6-dimethylamino-pyrimidin-4-yl, pyrazin-2-yl, 6-methoxy-pyrazin-2-yl, 6-methoxy-pyridazin-3-yl, pyrazol-1-yl-methyl, 1H-imidazol-4-yl, 3H-[1,2,3]triazol-4-yl, 5-methyl-1 H-imidazol-4-yl, 1,2-dimethyl-1H-imidazol-4-yl, 1,5-dimethyl-1 H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl, 2-cyclopropyl-1 H-imidazol-4-yl, 2-cyclopropyl-1-methyl-1H-imidazol-4-yl, oxazol-2-yl, 4,5-dimethyl-oxazol-2-yl, or pyridin-2-yl; notably HET is 1H-tetrazol-5-yl, 3-hydroxy-isoxazol-5-yl, 1H-imidazol-4-yl, 5-methyl-1H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl); R m1< represents (C 1-6 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); -NR N1< R N2< , wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, or (C 3-6 )cycloalkyl;(especially such group -NR N1< R N2< represents amino, methylamino, ethylamino, or propylamino); or -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, isobutyl), (C 3-6 )cycloalkyl (especially cyclobutyl), or 2-fluoro-vinyl; and R m2< represents hydrogen, fluoro, or chloro; or R p< represents hydrogen; R m1< represents 1H-pyrazol-1-yl; or -X 1< -COOH, wherein X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), or -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH 2 -CH 2 -*), wherein the asterisks indicate the bond that is linked to the -COOH group [wherein in particular such group -X 1< -COOH represents-COOH, -CH 2 -COOH, -CH 2 -CH 2 -COOH, -O-CH 2 -CH 2 -COOH]; and R m2< represents hydrogen, (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy); or -S-(C 1-4 )alkyl (especially -S-methyl, -S-ethyl, -S-n-propyl); or Ar 1< represents a 5-membered heteroaryl group of the structure (Ar-II): wherein in (Ar-II) the ring A represents a thiophenyl or a thiazolyl ring (wherein it is well understood that in (Ar-II) the substituent R 7< is attached in meta-position with respect to the point of attachment of the rest of the molecule) (especially ring A represents thiophen-2-yl wherein R 7< is attached in position 5, or thiophen-2-yl wherein R 7< is attached in position 4; or thiazol-2-yl wherein R 7< is attached in position 5); wherein • R 7< represents 3-hydroxy-oxetan-3-yl; hydroxy; 2,2,2-trifluoro-1,1-dihydroxy-ethyl; -X 1< -CO-R O1< , wherein X 1< represents a direct bond, (C 1-3 )alkylene (especially -CH 2 -, -CH 2 -CH 2 -), -O-(C 1-3 )alkylene-* (especially -O-CH 2 -*, -O-CH(CH 3 )-*, -O-CH 2 -CH 2 -*), -NH-(C 1-3 )alkylene-* (especially -NH-CH 2 -*, -NH-CH(CH 3 )-*), -S-CH 2 -*, -CF 2 -, -CH=CH-, -C≡C-, -NH-CO-*, -CO-, or (C 3-5 )cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-R O1< group; and R O1< represents ▪ -OH; ▪ -O-(C 1-4 )alkyl (especially ethoxy, methoxy); ▪ -NH-SO 2 -R S3< wherein R S3< represents (C 1-4 )alkyl, (C 3-6 )cycloalkyl wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 3-6 )cycloalkyl-(C 1-3 )alkylene wherein the (C 3-6 )cycloalkyl optionally contains a ring oxygen atom, (C 1-3 )fluoroalkyl, phenyl, or -NH 2 ; ▪ -O-phenyl; ▪ -O-CH 2 -CO-R O4< , wherein R O4< representshydroxy, or (C 1-4 )alkoxy, or -N[(C 1-4 )alkyl] 2 ; ▪ -O-CH 2 -O-CO-R O5< , wherein R O5< represents (C 1-4 )alkyl or (C 1-4 )alkoxy; or ▪ -O-CH 2 -CH 2 -N[(C 1-4 )alkyl] 2 (especially -O-CH 2 -CH 2 -N(CH 3 ) 2 ); ▪ (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; [wherein in particular, such group -X 1< -CO-R O1< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, - NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-NH-SO 2 -phenyl, -CO-O-CH 3 , -CO-NH-SO 2 -ethyl, -CO-NH-SO 2 -NH 2 , -CO-O-CH 2 -COOH, -CO-O-CH 2 -CH 2 -N(CH 3 ) 2 , -CO-O-CH 2 -CO-N(CH 3 ) 2 , -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl, (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl-O-CO-, -CH 2 -COOH, -CH 2 -CO-O-ethyl, -CH 2 -CH 2 -COOH, - CF 2 -COOH, -CH=CH-COOH, -NH-CO-COOH, -CO-COOH, -O-CH 2 -CH 2 -COOH, -O-CH(CH 3 )-COOH, -NH-CH(CH 3 )-COOH, -NH-CH 2 -CO-O-CH 3 , -COO-phenyl, 1-carboxy-cyclopropan-1-yl, 1-carboxy-cyclopentan-1-yl]; -CO-CH 2 -OH; -CO-H; hydroxy-(C 1-4 )alkyl (especially hydroxymethyl, 1-hydroxy-ethyl); -NR N1< R N2< , wherein ▪ R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, or (C 3-6 )cycloalkyl (wherein preferably at least one of R N1< and R N2< represents hydrogen); ▪ or R N1< independently represents hydrogen or (C 1-4 )alkyl, and R N2< independently represents -CO-H, -CO-(C 1-3 )alkyl, or -CO-(C 1-3 )alkylene-OH: (especially such group -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino, or - NH-CO-H, -N(C 2 H 5 )-CO-H, -NH-CO-C 2 H 5 , -NH-CO-CH 2 -CH 2 -OH, or -NH-CO-O-CH 3 ); -CO-NR N3< R N4< wherein R N3< and R N4< independently represent hydrogen, (C 1-4 )alkyl, hydroxy-(C 2-4 )alkyl, (C 1-3 )alkoxy-(C 2-4 )alkyl, dimethylamino-(C 2-4 )alkyl, (C 1-4 )alkoxy, hydroxy-(C 2-4 )alkoxy, benzyloxy, or hydroxy (wherein preferably at least one of R N3< and R N4< represents hydrogen; and wherein particular examples of such group -CO-NR N3< R N4< are -CO-NH 2 , -CO-NH(CH 3 ), -CO-NH(C 2 H 5 ), -CO-NH-O-methyl, -CO-NH-O-ethyl, -CO-NH-O-isopropyl, -CO-NH-C 2 H 4 -OH, -CO-NH-C 2 H 4 -OCH 3 , -CO-NH-O-C 2 H 4 -OH, -CO-NH-C 2 H 4 -N(CH 3 ) 2 , -CO-NH-O-benzyl, or -CO-N(CH 3 ) 2 , -CO-NH-isopropyl, or -CO-NH-OH); -NH-CO-NR N5< R N6< wherein R N5< and R N6< independently represent hydrogen or (C 1-4 )alkyl (especially such group represents-NH-CO-NH 2 , -NH-CO-NH-C 2 H 5 ); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (encompassing its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl), or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (encompassing its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl); or HET, wherein HET represents a 5- or 6-membered heteroaryl (especially 5-membered heteroaryl selected from oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, and tetrazolyl; or 6-membered heteroaryl selected from pyridinyl, pyrimidinyl, pyridazinyl, and pyrazinyl, notably tetrazolyl, imidazoloyl, or isoxazolyl), wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl), (C 1-4 )alkoxy (especially methoxy), -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C 3-5 )cycloalkyl (especially cyclopropyl), or -NR N9< R N10< wherein R N9< and R N10< independently represent hydrogen or (C 1-3 )alkyl (especially amino, dimethylamino) (especially the substituents are independently selected from (C 1-3 )alkyl (especially methyl), and hydroxy); (in particular, such group HET is 1H-tetrazol-5-yl, 3-hydroxy-isoxazol-5-yl, 1H-imidazol-4-yl, 5-methyl-1H-imidazol-4-yl, or 2,5-dimethyl-1H-imidazol-4-yl; notably 1H-tetrazol-5-yl, or 3-hydroxy-isoxazol-5-yl); • and (R 6< ) n represents one optional substituent (i.e. n represents the integer 0, or 1) independently selected from (C 1-6 )alkyl (especially methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, 1-methyl-propan-1-yl, tert.-butyl, 3-methyl-butyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy); halogen (especially fluoro or chloro); (C 3-6 )cycloalkyl (especially cyclopropyl); (C 3-6 )cycloalkyl-oxy (especially cyclobutyl-oxy, cyclopentyl-oxy); hydroxy; pyridinyl; and -NR N1< R N2< , wherein R N1< and R N2< independently represent hydrogen, (C 1-4 )alkyl, or (C 3-6 )cycloalkyl; (especially such group -NR N1< R N2< represents amino, methylamino, ethylamino, propylamino); [wherein, if present, such substituent R 6< is especially attached in the other meta-position with respect to the point of attachment of the rest of the molecule, i.e. especially ring A represents thiophen-2-yl wherein R 7< is attached in position 5 and R 6< is attached in position 4, or thiophen-2-yl wherein R 7< is attached in position 4 and R 6< is attached in position 5; or thiazol-2-yl wherein R 7< is attached in position 5 and R 6< is attached in position 4)]; or Ar 1< represents 9- or 10-membered bicyclic heteroaryl (especially indazolyl, benzoimidazolyl, indolyl, benzotriazolyl, benzooxazolyl, quinoxalinyl, isoquinolinyl, quinolinyl, pyrrolopyridinyl, or imidazopyridinyl); wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from (C 1-4 )alkyl (especially methyl); (C 1-4 )alkoxy (especially methoxy); (C 1-3 )fluoroalkyl (especially trifluoromethyl); (C 1-3 )fluoroalkoxy (especially trifluoromethoxy); halogen; cyano; hydroxy, or -(C 0-3 )alkylene-COOR O2< wherein R O2< represents hydrogen or (C 1-4 )alkyl (especially methyl); (especially such 9- to 10-membered bicyclic heteroaryl is 1H-indazol-6-yl, 1-methyl-1H-indazol-6-yl, 3-methyl-1H-indazol-6-yl, 3-carboxy-1H-indazol-6-yl, 1H-benzoimidazol-5-yl, 2-methyl-1H-benzoimidazol-5-yl, 2-trifluoromethyl-1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1-methyl-1H-indol-5-yl, 2-carboxy-1H-indol-5-yl, 7-carboxy-1H-indol-4-yl, 7-carboxy-1-methyl-1H-indol-4-yl, 1H-benzotriazol-5-yl, 2-methyl-benzooxazol-5-yl, 2-methyl-benzooxazol-6-yl, quinoxalin-6-yl, isoquinolin-7-yl, quinolin-6-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indazol-5-yl, 1H-pyrrolo[2,3-c]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, 1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl, imidazo[1,2-a]pyridin-6-yl, 3-methoxy-1 H-indazol-6-yl, 6-methoxy-1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1H-indol-2-yl; preferably such 9- to 10-membered bicyclic heteroaryl is 1H-benzoimidazol-5-yl, 1H-indol-6-yl, 1H-indol-5-yl, 1H-indol-2-yl, 1H-indazol-5-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1H-indol-2-yl); or Ar 1< represents a group of the structure (Ar-III): wherein ring (B) represents a non-aromatic 5- or 6-membered ring fused to the phenyl group, wherein ring (B) comprises one or two heteroatoms independently selected from nitrogen and oxygen (notably such group (Ar-III) is 2,3-dihydro-benzofuranyl, 2,3-dihydro-1H-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-1H-indazolyl, 2,3-dihydro-1H-benzo[d]imidazolyl, 2,3-dihydrobenzo[d]isoxazolyl, 2,3-dihydro-isoindolyl, 2,3-dihydro-benzooxazolyl, 1,2,3,4-tetrahydro-quinazolinyl, 1,2,3,4-tetrahydro-isoquinolinyl, or 1,2,3,4-tetrahydro-phthalazinyl); wherein said ring (B) independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo, (C 1-6 )alkyl (especially methyl, ethyl, propyl, butyl, isobutyl) and -(C 0-3 )alkylene-COOR O3< wherein R O3< representshydrogen or (C 1-3 )alkyl (especially such group (Ar-III) is 2,3-dihydro-benzofuran-5-yl, 2,3-dihydro-1H-indol-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, 3-oxo-2,3-dihydro-1H-indazol-5-yl, 3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-2,3-dihydro-1 H-benzo[d]imidazol-5-yl, 3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl, 2-oxo-1,3-dihydro-indol-5-yl, 1-oxo-2,3-dihydro-isoindol-5-yl, 3-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-propyl-1-oxo-2,3-dihydro-isoindol-5-yl, 3-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-methyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-ethyl-1-oxo-2,3-dihydro-isoindol-5-yl, 1-oxo-2-propyl-2,3-dihydro-isoindol-5-yl, 2-isobutyl-1-oxo-2,3-dihydro-isoindol-5-yl, 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 1-(carboxymethyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, 1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl, or 1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl; preferably such group (Ar-III) is 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, or 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl). 12) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents a phenyl group selected from: a) ;or b) c) or d) or Ar 1< represents a thiophenyl group selected from: a) or b) or c) or Ar 1< represents a thiazoyl group selected from: or Ar 1< represents 9- or 10-membered bicyclic heteroaryl selected from a) or b) or Ar 1< represents a group selected from: a) or b) and 13) Another embodiment relates to compounds according to any one of embodiments 1) to 5), wherein Ar 1< represents a phenyl group selected from: a) ;or b) or c) or d) or Ar 1< represents a thiophenyl group selected from: a) or b) c) or Ar 1< represents a thiazoyl group selected from: or Ar 1< represents 9- or 10-membered bicyclic heteroaryl selected from a) or b) or Ar 1< represents a group of selected from: 14) Another embodiment relates to compounds according to any one of embodiments 1) to 13), wherein (R 1< ) n represents: one, two or three optional substituents (i.e. n represents the integer 0, 1, 2, or 3); wherein said substituents are attached to the phenyl moiety of the indole ring; wherein said substituents are independently selected from (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially fluoro, chloro, or bromo), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; or two R 1< together form a group -O-CH 2 -O-, and the remaining R 1< , if present, represents halogen (especially fluoro or chloro); or (R 1< ) n represents: one substituent in position 3 of the indole ring, wherein said substituent is selected from (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially fluoro, chloro, or bromo), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano (especially such substituent is fluoro); and, in addition, one or two optional substituents (i.e. 0, 1, or 2 additional substituents) attached to the phenyl moiety of the indole ring; wherein said substituents are independently selected from (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially fluoro, chloro, or bromo), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; or two R 1< together form a group -O-CH 2 -O- attached to the phenyl moiety of the indole ring; and said substituent in position 3 of the indole moiety, if present, represents halogen (especially fluoro or chloro); wherein it is understood that the indole ring is in addition substituted by the substituent R 2< . 15) Another embodiment relates to compounds according to any one of embodiments 1) to 13), wherein the group represents wherein R 2< represents (C 1-3 )alkyl (especially methyl), halogen (especially chloro), or cyano; and R 13< represents hydrogen; and R 14< , R 15< , R 16< , and R 17< independently represent the following: R 14< represents hydrogen, (C 1-3 )alkyl (especially methyl, ethyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially bromo, chloro, fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 14< represents methyl, methoxy, halogen, or cyano); R 15< represents hydrogen, (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially chloro, fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 15< represents hydrogen, methyl, chloro, or fluoro); R 16< represents hydrogen, (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 16< represents hydrogen, or fluoro); and R 17< represents hydrogen, (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially chloro, fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 17< represents hydrogen, chloro, or fluoro); wherein at least one of R 14< , R 15< , R 16< , and R 17< represents hydrogen; (and, preferably, at least one of R 14< , R 15< , R 16< , and R 17< is different from hydrogen; especially one of R 14< , R 16< , and R 17< is different from hydrogen); or R 14< and R 15< together form a group -O-CH 2 -O-, R 16< represents hydrogen and R 17< represents hydrogen or halogen (especially fluoro or chloro); or R 2< represents (C 1-3 )alkyl (especially methyl), halogen (especially chloro), or cyano; and R 13< represents fluoro; and R 14< , R 15< , R 16< , and R 17< independently represent the following: R 14< represents hydrogen, (C 1-3 )alkyl (especially methyl, ethyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially bromo, chloro, fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 14< represents hydrogen or methoxy); R 15< represents hydrogen, (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially chloro, fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 15< represents hydrogen); R 16< represents hydrogen, (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 16< represents hydrogen); and R 17< represents hydrogen, (C 1-3 )alkyl (especially methyl), (C 1-3 )alkoxy (especially methoxy), halogen (especially chloro, fluoro), (C 1-3 )fluoroalkyl (especially trifluoromethyl), (C 1-3 )fluoroalkoxy (especially trifluoromethoxy), or cyano; (especially R 17< represents hydrogen or fluoro); wherein at least two of R 14< , R 15< , R 16< , and R 17< represent hydrogen. 16) Another embodiment relates to compounds according to any one of embodiments 1) to 13), wherein the group represents wherein R 2< represents methyl, chloro, or cyano; and R 13< represents hydrogen; and R 14< , R 15< , R 16< , and R 17< independently represent the following: R 14< represents hydrogen, methyl, ethyl, methoxy, bromo, chloro, fluoro, trifluoromethyl, trifluoromethoxy, or cyano (especially R 14< represents methyl, methoxy, halogen, or cyano); R 15< represents hydrogen, methyl, methoxy, chloro, fluoro (especially R 15< represents hydrogen, methyl, chloro, or fluoro); R 16< represents hydrogen, methoxy, or fluoro; (especially R 16< represents hydrogen, or fluoro); and R 17< represents hydrogen, methyl, methoxy, chloro, fluoro, or cyano; (especially R 17< represents hydrogen, chloro, or fluoro); wherein at least one of R 14< , R 15< , R 16< , and R 17< represents hydrogen; (and, preferably, at least one of R 14< , R 15< , R 16< , and R 17< is different from hydrogen; especially at least one of R 14< , R 16< , and R 17< is different from hydrogen); or R 14< and R 15< together form a group -O-CH 2 -O-, R 16< represents hydrogen and R 17< represents hydrogen or halogen (especially fluoro or chloro); or R 2< represents (C 1-3 )alkyl (especially methyl), halogen (especially chloro), or cyano; and R 13< represents fluoro; and R 14< , R 15< , R 16< , and R 17< independently represent the following: R 14< represents hydrogen, methyl, ethyl, methoxy, bromo, chloro, fluoro, trifluoromethyl, trifluoromethoxy, or cyano (especially R 14< represents hydrogen or methoxy); R 15< represents hydrogen, methyl, methoxy, chloro, fluoro (especially R 15< represents hydrogen); R 16< represents hydrogen, methoxy, or fluoro; (especially R 16< represents hydrogen); and R 17< represents hydrogen, methyl, methoxy, chloro, fluoro, or cyano; (especially R 17< represents hydrogen or fluoro); wherein at least two of R 14< , R 15< , R 16< , and R 17< represent hydrogen. 17) Another embodiment relates to compounds according to any one of embodiments 1) to 13), wherein the group represents wherein R 2< represents methyl, chloro, or cyano; and R 13< represents hydrogen; and R 14< represents hydrogen; R 17< represents hydrogen, chloro or fluoro; R 16< represents hydrogen, fluoro, chloro or methoxy; and R 15< represents hydrogen, methyl, chloro, fluoro or methoxy; wherein preferably at least one of R 15< , R 16< , and R 17< is different from hydrogen; especially R 16< and / or R 17< is / are different from hydrogen; or R 14< represents methyl, R 17< represents hydrogen, chloro or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen or fluoro; wherein at least one of R 15< , R 16< , and R 17< represents hydrogen; or R 14< represents methoxy, R 17< represents hydrogen, methyl, chloro or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen; or R 14< represents halogen (especially bromo, chloro, fluoro), R 17< represents hydrogen, methyl, methoxy, chloro or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen or fluoro; wherein at least one of R 15< , R 16< , and R 17< represents hydrogen; or R 14< represents cyano; R 17< represents hydrogen, or fluoro; R 16< represents hydrogen; and R 15< represents hydrogen; or R 14< and R 15< together form a group -O-CH 2 -O-, R 16< represents hydrogen and R 17< represents hydrogen or chloro; or R 2< represents methyl, chloro, or cyano; and R 13< represents fluoro; and R 14< , R 17< , R 16< and R 15< represent hydrogen; or R 14< represents methoxy, R 17< represents fluoro; and R 16< and R 15< represent hydrogen. 18) Another embodiment relates to compounds according to any one of embodiments 1) to 13), wherein the group represents wherein R 2< represents methyl, chloro, or cyano; and R 13< represents hydrogen; and R 14< represents hydrogen; R 17< represents hydrogen, chloro or fluoro; R 16< represents hydrogen, fluoro, chloro, or methoxy; and R 15< represents hydrogen, methyl, chloro, fluoro or methoxy; wherein preferably at least one of R 15< , R 16< , and R 17< is different from hydrogen; especially R 16< and / or R 17< is / are different from hydrogen; or R 14< represents methyl, R 17< represents hydrogen, chloro or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen or fluoro; wherein at least one of R 15< , R 16< , and R 17< represents hydrogen; or R 14< represents methoxy, R 17< represents hydrogen, methyl, chloro or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen; or R 14< represents halogen (especially bromo, chloro, fluoro), R 17< represents hydrogen, methyl, methoxy, chloro or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen or fluoro; wherein at least one of R 15< , R 16< , and R 17< represents hydrogen; or R 14< represents cyano; R 17< represents hydrogen, or fluoro; R 16< represents hydrogen; and R 15< represents hydrogen; or R 14< and R 15< together form a group -O-CH 2 -O-, R 16< represents hydrogen and R 17< represents hydrogen or chloro; or R 2< represents methyl, chloro, or cyano; and R 13< represents fluoro; and R 14< , R 17< , R 16< and R 15< represent hydrogen; or R 14< represents methoxy, R 17< represents fluoro; and R 16< and R 15< represent hydrogen. 19) Another embodiment relates to compounds according to any one of embodiments 1) to 13), wherein the group represents wherein R 2< represents methyl, chloro, or cyano (especially methyl or cyano); and R 13< represents hydrogen; and R 14< represents hydrogen; R 17< represents hydrogen or fluoro; R 16< represents hydrogen, or fluoro; and R 15< represents hydrogen, methyl, chloro, or fluoro; wherein preferably at least one of R 15< , R 16< , and R 17< is different from hydrogen; especially R 16< and / or R 17< is / are different from hydrogen; or R 14< represents methyl, R 17< represents hydrogen or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen or fluoro; wherein at least one of R 15< , R 16< , and R 17< represents hydrogen; or R 14< represents methoxy, R 17< represents hydrogen, chloro or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen; or R 14< represents halogen (especially bromo, chloro, fluoro), R 17< represents hydrogen or fluoro; R 16< represents hydrogen, chloro or fluoro; and R 15< represents hydrogen or fluoro; wherein at least one of R 15< , R 16< , and R 17< represents hydrogen. 20) Another embodiment relates to compounds according to any one of embodiments 1) to 19), wherein R 2< represents methyl. 21) Another embodiment relates to compounds according to any one of embodiments 1) to 19), wherein R 2< represents cyano. 22) Another embodiment relates to compounds according to any one of embodiments 1) to 13), wherein the group represents a group selected from the following groups A), B), C), D) and E): A) B) C) D) and (especially) E) wherein the groups of A), B) and E) are preferred groups. 23) The invention, thus, relates to compounds of the formula (I) as defined in embodiment 1), or to such compounds further limited by the characteristics of any one of embodiments 2) to 22), under consideration of their respective dependencies; to pharmaceutically acceptable salts thereof; and to the use of such compounds as medicaments especially in the prevention / prophylaxis or treatment of diseases which respond to the blockage of the EP2 receptors and / or the EP4 receptors as described herein below. For avoidance of any doubt, especially the following embodiments relating to the compounds of formula (I) are thus possible and intended and herewith specifically disclosed in individualized form: 1, 2+1, 4+1, 4+2+1, 5+1, 5+2+1, 5+4+1, 5+4+2+1, 7+1, 7+2+1, 7+4+1, 7+4+2+1, 7+5+1, 7+5+2+1, 7+5+4+1, 7+5+4+2+1, 9+1, 9+2+1, 9+4+1, 9+4+2+1, 9+5+1, 9+5+2+1, 9+5+4+1, 9+5+4+2+1, 11+1, 11+2+1, 11+4+1, 11+4+2+1, 11+5+1, 11+5+2+1, 11+5+4+1, 11+5+4+2+1, 12+1, 12+2+1, 12+4+1, 12+4+2+1, 12+5+1, 12+5+2+1, 12+5+4+1, 12+5+4+2+1, 13+1, 13+2+1, 13+4+1, 13+4+2+1, 13+5+1, 13+5+2+1, 13+5+4+1, 13+5+4+2+1, 15+1, 15+2+1, 15+4+1, 15+4+2+1, 15+5+1, 15+5+2+1, 15+5+4+1, 15+5+4+2+1, 15+7+1, 15+7+2+1, 15+7+4+1, 15+7+4+2+1, 15+7+5+1, 15+7+5+2+1, 15+7+5+4+1, 15+7+5+4+2+1, 15+9+1, 15+9+2+1, 15+9+4+1, 15+9+4+2+1, 15+9+5+1, 15+9+5+2+1, 15+9+5+4+1, 15+9+5+4+2+1, 15+11+1, 15+11+2+1, 15+11+4+1, 15+11+4+2+1, 15+11+5+1, 15+11+5+2+1, 15+11+5+4+1, 15+11+5+4+2+1, 15+12+1, 15+12+2+1, 15+12+4+1, 15+12+4+2+1, 15+12+5+1, 15+12+5+2+1, 15+12+5+4+1, 15+12+5+4+2+1, 15+13+1, 15+13+2+1, 15+13+4+1, 15+13+4+2+1, 15+13+5+1, 15+13+5+2+1, 15+13+5+4+1, 15+13+5+4+2+1, 16+1, 16+2+1, 16+4+1, 16+4+2+1, 16+5+1, 16+5+2+1, 16+5+4+1, 16+5+4+2+1, 16+7+1, 16+7+2+1, 16+7+4+1, 16+7+4+2+1, 16+7+5+1, 16+7+5+2+1, 16+7+5+4+1, 16+7+5+4+2+1, 16+9+1, 16+9+2+1, 16+9+4+1, 16+9+4+2+1, 16+9+5+1, 16+9+5+2+1, 16+9+5+4+1, 16+9+5+4+2+1, 16+11+1, 16+11+2+1, 16+11+4+1, 16+11+4+2+1, 16+11+5+1, 16+11+5+2+1, 16+11+5+4+1, 16+11+5+4+2+1, 16+12+1, 16+12+2+1, 16+12+4+1, 16+12+4+2+1, 16+12+5+1, 16+12+5+2+1, 16+12+5+4+1, 16+12+5+4+2+1, 16+13+1, 16+13+2+1, 16+13+4+1, 16+13+4+2+1, 16+13+5+1, 16+13+5+2+1, 16+13+5+4+1, 16+13+5+4+2+1, 20+1, 20+2+1, 20+4+1, 20+4+2+1, 20+5+1, 20+5+2+1, 20+5+4+1, 20+5+4+2+1, 20+7+1, 20+7+2+1, 20+7+4+1, 20+7+4+2+1, 20+7+5+1, 20+7+5+2+1, 20+7+5+4+1, 20+7+5+4+2+1, 20+15+1, 20+15+2+1, 20+15+4+1, 20+15+4+2+1, 20+15+5+1, 20+15+5+2+1, 20+15+5+4+1, 20+15+5+4+2+1, 20+15+7+1, 20+15+7+2+1, 20+15+7+4+1, 20+15+7+4+2+1, 20+15+7+5+1, 20+15+7+5+2+1, 20+15+7+5+4+1, 20+15+7+5+4+2+1, 20+15+9+1, 20+15+9+2+1, 20+15+9+4+1, 20+15+9+4+2+1, 20+15+9+5+1, 20+15+9+5+2+1, 20+15+9+5+4+1, 20+15+9+5+4+2+1, 20+15+11+1, 20+15+11+2+1, 20+15+11+4+1, 20+15+11+4+2+1, 20+15+11+5+1, 20+15+11+5+2+1, 20+15+11+5+4+1, 20+15+11+5+4+2+1, 20+15+12+1, 20+15+12+2+1, 20+15+12+4+1, 20+15+12+4+2+1, 20+15+12+5+1, 20+15+12+5+2+1, 20+15+12+5+4+1, 20+15+12+5+4+2+1, 20+15+13+1, 20+15+13+2+1, 20+15+13+4+1, 20+15+13+4+2+1, 20+15+13+5+1, 20+15+13+5+2+1, 20+15+13+5+4+1, 20+15+13+5+4+2+1, 20+16+1, 20+16+2+1, 20+16+4+1, 20+16+4+2+1, 20+16+5+1, 20+16+5+2+1, 20+16+5+4+1, 20+16+5+4+2+1, 20+16+7+1, 20+16+7+2+1, 20+16+7+4+1, 20+16+7+4+2+1, 20+16+7+5+1, 20+16+7+5+2+1, 20+16+7+5+4+1, 20+16+7+5+4+2+1, 20+16+9+1, 20+16+9+2+1, 20+16+9+4+1, 20+16+9+4+2+1, 20+16+9+5+1, 20+16+9+5+2+1, 20+16+9+5+4+1, 20+16+9+5+4+2+1, 20+16+11+1, 20+16+11+2+1, 20+16+11+4+1, 20+16+11+4+2+1, 20+16+11+5+1, 20+16+11+5+2+1, 20+16+11+5+4+1, 20+16+11+5+4+2+1, 20+16+12+1, 20+16+12+2+1, 20+16+12+4+1, 20+16+12+4+2+1, 20+16+12+5+1, 20+16+12+5+2+1, 20+16+12+5+4+1, 20+16+12+5+4+2+1, 20+16+13+1, 20+16+13+2+1, 20+16+13+4+1, 20+16+13+4+2+1, 20+16+13+5+1, 20+16+13+5+2+1, 20+16+13+5+4+1, 20+16+13+5+4+2+1, 21+1, 21+2+1, 21+4+1, 21+4+2+1, 21+5+1, 21+5+2+1, 21+5+4+1, 21+5+4+2+1, 21+7+1, 21+7+2+1, 21+7+4+1, 21+7+4+2+1, 21+7+5+1, 21+7+5+2+1, 21+7+5+4+1, 21+7+5+4+2+1, 21+15+1, 21+15+2+1, 21+15+4+1, 21+15+4+2+1, 21+15+5+1, 21+15+5+2+1, 21+15+5+4+1, 21+15+5+4+2+1, 21+15+7+1, 21+15+7+2+1, 21+15+7+4+1, 21+15+7+4+2+1, 21+15+7+5+1, 21+15+7+5+2+1, 21+15+7+5+4+1, 21+15+7+5+4+2+1, 21+15+9+1, 21+15+9+2+1, 21+15+9+4+1, 21+15+9+4+2+1, 21+15+9+5+1, 21+15+9+5+2+1, 21+15+9+5+4+1, 21+15+9+5+4+2+1, 21+15+11+1, 21+15+11+2+1, 21+15+11+4+1, 21+15+11+4+2+1, 21+15+11+5+1, 21+15+11+5+2+1, 21+15+11+5+4+1, 21+15+11+5+4+2+1, 21+15+12+1, 21+15+12+2+1, 21+15+12+4+1, 21+15+12+4+2+1, 21+15+12+5+1, 21+15+12+5+2+1, 21+15+12+5+4+1, 21+15+12+5+4+2+1, 21+15+13+1, 21+15+13+2+1, 21+15+13+4+1, 21+15+13+4+2+1, 21+15+13+5+1, 21+15+13+5+2+1, 21+15+13+5+4+1, 21+15+13+5+4+2+1, 21+16+1, 21+16+2+1, 21+16+4+1, 21+16+4+2+1, 21+16+5+1, 21+16+5+2+1, 21+16+5+4+1, 21+16+5+4+2+1, 21+16+7+1, 21+16+7+2+1, 21+16+7+4+1, 21+16+7+4+2+1, 21+16+7+5+1, 21+16+7+5+2+1, 21+16+7+5+4+1, 21+16+7+5+4+2+1, 21+16+9+1, 21+16+9+2+1, 21+16+9+4+1, 21+16+9+4+2+1, 21+16+9+5+1, 21+16+9+5+2+1, 21+16+9+5+4+1, 21+16+9+5+4+2+1, 21+16+11+1, 21+16+11+2+1, 21+16+11+4+1, 21+16+11+4+2+1, 21+16+11+5+1, 21+16+11+5+2+1, 21+16+11+5+4+1, 21+16+11+5+4+2+1, 21+16+12+1, 21+16+12+2+1, 21+16+12+4+1, 21+16+12+4+2+1, 21+16+12+5+1, 21+16+12+5+2+1, 21+16+12+5+4+1, 21+16+12+5+4+2+1, 21+16+13+1, 21+16+13+2+1, 21+16+13+4+1, 21+16+13+4+2+1, 21+16+13+5+1, 21+16+13+5+2+1, 21+16+13+5+4+1, 21+16+13+5+4+2+1, 22+1, 22+2+1, 22+4+1, 22+4+2+1, 22+5+1, 22+5+2+1, 22+5+4+1, 22+5+4+2+1, 22+7+1, 22+7+2+1, 22+7+4+1, 22+7+4+2+1, 22+7+5+1, 22+7+5+2+1, 22+7+5+4+1, 22+7+5+4+2+1, 22+9+1, 22+9+2+1, 22+9+4+1, 22+9+4+2+1, 22+9+5+1, 22+9+5+2+1, 22+9+5+4+1, 22+9+5+4+2+1, 22+11+1, 22+11+2+1, 22+11+4+1, 22+11+4+2+1, 22+11+5+1, 22+11+5+2+1, 22+11+5+4+1, 22+11+5+4+2+1, 22+12+1, 22+12+2+1, 22+12+4+1, 22+12+4+2+1, 22+12+5+1, 22+12+5+2+1, 22+12+5+4+1, 22+12+5+4+2+1, 22+13+1, 22+13+2+1, 22+13+4+1, 22+13+4+2+1, 22+13+5+1, 22+13+5+2+1, 22+13+5+4+1, 22+13+5+4+2+1. In the list above the numbers refer to the embodiments according to their numbering provided hereinabove whereas "+" indicates the dependency from another embodiment. The different individualized embodiments are separated by commas. In other words, "16+13+4+1" for example refers to embodiment 16) depending on embodiment 13), depending on embodiment 4), depending on embodiment 1), i.e. embodiment "16+13+4+1" corresponds to the compounds of formula (I) according to embodiment 1) further limited by all the features of the embodiments 4), 13), and 16). 24) A second aspect of the invention relates to compounds of the formula (I) according to embodiment 1) which are also compounds of the formula (II) wherein R 2< represents (C 1-3 )alkyl (especially methyl), halogen (especially chloro), or cyano; and R 14< , R 15< , R 16< , and R 17< independently represent the following: R 14< represents hydrogen, methyl, ethyl, methoxy, bromo, chloro, fluoro, trifluoromethyl, trifluoromethoxy, or cyano (especially R 14< represents methyl, methoxy, halogen, or cyano); R 15< represents hydrogen, methyl, methoxy, chloro, fluoro (especially R 15< represents hydrogen, methyl, chloro, or fluoro); R 16< represents hydrogen, methoxy, or fluoro; (especially R 16< represents hydrogen, or fluoro); and R 17< represents hydrogen, methyl, methoxy, chloro, fluoro, or cyano; (especially R 17< represents hydrogen, chloro, or fluoro); wherein at least one of R 14< , R 15< , R 16< , and R 17< represents hydrogen; (and, preferably, at least one of R 14< , R 15< , R 16< , and R 17< is different from hydrogen; especially one of R 14< , R 16< , and R 17< is different from hydrogen); or R 14< and R 15< together form a group -O-CH 2 -O-, R 16< represents hydrogen and R 17< represents hydrogen or halogen (especially fluoro or chloro); and Ar 1< is as defined in embodiment 10); wherein the characteristics disclosed in embodiments 2) to 22) are intended to apply mutatis mutandis also to the compounds formula (II) according to embodiment 24); wherein especially the following embodiments are thus possible and intended and herewith specifically disclosed in individualized form: 24+12, 24+13, 24+17, 24+17+12, 24+17+13, 24+18, 24+18+12, 24+18+13, 24+19, 24+19+12, 24+19+13, 24+22, 24+22+12, 24+22+13, 24+20, 24+20+17, 24+20+17+12, 24+20+17+13, 24+20+18, 24+20+18+12, 24+20+18+13, 24+20+19, 24+20+19+12, 24+20+19+13, 24+21, 24+21+17, 24+21+17+12, 24+21+17+13, 24+21+18, 24+21+18+12, 24+21+18+13, 24+21+19, 24+21+19+12, 24+21+19+13. In the list above the numbers refer to the embodiments according to their numbering provided hereinabove whereas "+" indicates the limitations as outlined above. 25) A third aspect of the invention relates to compounds of the formula (I) according to embodiment 1) which are also compounds of the formula (III) wherein the group: is as defined in embodiment 15); and Ar 1< is as defined in embodiment 7); wherein the characteristics disclosed in embodiments 2) to 22) are intended to apply mutatis mutandis also to the compounds formula (III) according to embodiment 25); wherein especially the following embodiments are thus possible and intended and herewith specifically disclosed in individualized form: 25, 25+9, 25+11, 25+12, 25+13, 25+16+9, 25+16+11, 25+16+12, 25+16+13, 25+16, 25+18+9, 25+18+11, 25+18+12, 25+18+13, 25+18, 25+20+9, 25+20+11, 25+20+12, 25+20+13, 25+20+16+9, 25+20+16+11, 25+20+16+12, 25+20+16+13, 25+20+16, 25+20+18+9, 25+20+18+11, 25+20+18+12, 25+20+18+13, 25+20+18, 25+20, 25+21+9, 25+21+11, 25+21+12, 25+21+13, 25+21+16+9, 25+21+16+11, 25+21+16+12, 25+21+16+13, 25+21+16, 25+21+18+9, 25+21+18+11, 25+21+18+12, 25+21+18+13, 25+21+18, 25+21, 25+22+9, 25+22+11, 25+22+12, 25+22+13, 25+22. In the list above the numbers refer to the embodiments according to their numbering provided hereinabove whereas "+" indicates the limitations as outlined above. 26) Another embodiment relates to compounds of formula (III) according to embodiment 25), wherein the group: represents a group selected from the following groups A), B), C), D) and E): A) B) C) D) E) wherein the groups of B) and E) are preferred groups; and Ar 1< represents phenyl, or 5-membered heteroaryl selected from thiophenyl and thiazolyl; wherein said phenyl or 5-membered heteroaryl independently is mono-, di- or tri-substituted; wherein one of said substituents is selected from -X 1< -CO-R 01< , wherein ▪ X 1< represents a direct bond, -CH 2 -CH 2 -, -O-CH 2 -*, -NH-CH 2 -*, -CH=CH-, or -NH-CO-*; wherein the asterisks indicate the bond that is linked to the -CO-R 01< group; and ▪ R 01< represents -OH; -O-(C 1-4 )alkyl (especially ethoxy, methoxy); -NH-SO 2 -R S3< wherein R S3< represents (C 1-3 )alkyl, cyclopropyl, or -NH 2 ; -O-CH 2 -CO-R 0 4< , wherein R 04< representshydroxy, or (C 1-4 )alkoxy; or -O-CH 2 -O-CO-R 05< , wherein R 05< represents (C 1-4 )alkyl or (C 1-4 )alkoxy; [wherein in particular, such group -X 1< - CO-R 01< represents -COOH, -CO-O-C 2 H 5 , -O-CH 2 -COOH, - NH-CH 2 -COOH, -CO-NH-SO 2 -CH 3 , -CO-NH-SO 2 -C(CH 3 ) 2 , -CO-NH-SO 2 -cyclopropyl, -CO-O-CH 3 , -CO-NH-SO 2 -ethyl, -CO-NH-SO 2 -NH 2 , -CO-O-CH 2 -COOH, -CO-O-CH 2 -O-CO-O-ethyl, -CO-O-CH 2 -O-CO-propyl, -CH 2 -CH 2 -COOH, -CH=CH-COOH, -NH-CO-COOH, -NH-CH 2 -CO-O-CH 3 ]; -NR N1< R N2< , wherein R N1< independently represents hydrogen or (C 1-3 )alkyl, and R N2< represents -CO-H (especially-NH-CO-H); 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl (encompassing its tautomeric form 5-hydroxy-[1,2,4]oxadiazol-3-yl), or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl (encompassing its tautomeric form 3-hydroxy-[1,2,4]oxadiazol-5-yl); 1H-tetrazol-5-yl; 3-hydroxy-isoxazol-5-yl; imidazolyl (especially 1H-imidazol-4-yl), which is unsubstituted, or mono- or di-substituted with methyl (in particular 1H-imidazol-4-yl, 5-methyl-1H-imidazol-4-yl, 2,5-dimethyl-1H-imidazol-4-yl); pyrazolyl (especially 1H-pyrazol-3-yl); isoxazolyl, oxazolyl, or thiadiazolyl; wherein said isoxazolyl, oxazolyl, or thiadiazolyl is mono-substituted with -NR N9< R N10< , wherein R N9< represents hydrogen, and R N10< represents hydrogen or methyl; (in particular 3-amino-isoxazol-5-yl, 2-amino-oxazol-5-yl, 5-methylamino-[1,3,4]thiadiazol-2-yl); (wherein especially said 5-membered heteroaryl represents thiophen-2-yl wherein said substituent is attached in position 5, or thiophen-2-yl wherein said substituent is attached in position 4; or thiazol-2-yl wherein said substituent is attached in position 5) and the remaining one or two of said substituents (if present) is / are independently selected from (C 1-4 )alkyl (especially ethyl, n-propyl, isobutyl); (C 1-4 )alkoxy (especially methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy); 2,2,2-trifluoroethoxy; halogen (especially fluoro or chloro); -NR N 1< R N2< , wherein R N1< represents hydrogen, and R N2< represents (C 1-3 )alkyl; -S-R S2< wherein R S2< represents (C 1-4 )alkyl (especially methyl, ethyl, n-propyl, isopropyl); or Ar 1< represents 8- to 10-membered bicyclic heteroaryl selected from unsubstituted benzimidazol (especially 1H-benzoimidazol-5-yl); unsubstituted indazolyl (especially 1H-indazol-5-yl), and indolyl which is unsubstituted or mono-substituted with -COOR 02< wherein R 02< representshydrogen or (C 1-4 )alkyl (especially methyl) (in particular 1H-indol-6-yl, 1H-indol-5-yl, 1H-indol-2-yl, 5-carboxy-1H-indol-2-yl, 6-carboxy-1H-indol-2-yl, 5-(methoxycarbonyl)-1H-indol-2-yl, or 6-(methoxycarbonyl)-1 H-indol-2-yl); or Ar 1< represents oxo-substituted 8- to 10-membered partially aromatic fused bicyclic heterocyclyl selected from 2-oxo-2,3-dihydro-benzooxazolyl, 3-oxo-2,3-dihydro-1H-indazolyl, 2-oxo-1,2,3,4-tetrahydro-quinazolinyl, 1-oxo-1,2,3,4-tetrahydro-isoquinolinyl; wherein said oxo-substituted heterocyclyl is unsubstituted (i.e. it carries no further substituent in addition to the oxo substituent) or mono-substituted on a ring nitrogen atom with (C 1-3 )alkyl (especially methyl); (in particular such heterocyclyl is 2-oxo-2,3-dihydro-benzooxazol-6-yl, 3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl, 1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl, 2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl, 1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl, or 1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl). 27) Another embodiment relates to most preferred compounds according to embodiment 1) which are selected from the following compounds: 3-Chloro-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; [6-(2,3-Dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 3-Ethyl-5-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-Ethyl-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Chloro-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 5-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; {6-[4-(3-Amino-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 3-Ethoxy-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(6-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethyl-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(4,6-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-6-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-6-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 5-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(4,6,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(4,5,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; {6-[4-(3-Amino-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}amine; 5-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Ethylamino-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-2-carboxylic acid; 2-Chloro-4-{6-[2-(6-chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 5-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 1-Ethyl-3-(4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-urea; {6-[4-(2-Amino-oxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; {6-[4-(2-Amino-oxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 2-(4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; 2-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}amine; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Butoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; {6-[4-(2-Amino-oxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(6,7-difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; {6-[3-Ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[3-ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pynmidin-4-yl}-amine; {6-[3-Ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; {6-[3-Ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; 3-Butoxy-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Butoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-propoxy-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-propoxy-thiophene-2-carboxylic acid; 3-(4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; 6-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,2-dihydro-indazol-3-one; 4-{6-[2-(2-Chloro-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 5-{6-[2-(2-Chloro-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(4-Bromo-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[5-(1H-tetrazol-5-yl)-thiophen-2-yl]-pyrimidin-4-yl}-amine; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-hydroxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 1-(2-{6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; N-(5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-methanesulfonamide; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenoxy)-acetic acid; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid; 5-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; N-(5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-benzenesulfonamide; Propane-2-sulfonic acid (5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-amide; Cyclopropanesulfonic acid (5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-amide; and 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid methylamide. 28) In addition to the most preferred compounds listed in embodiment 27), further preferred compounds according to embodiment 1) are selected from the following compounds: 3-Chloro-5-{6-[2-(4-chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Chloro-5-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; (2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 5-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-thiophene-2-carboxylic acid; [6-(2,3-Dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[4-(1H-Imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(2-methyl-1H-benzoimidazol-5-yl)-pyrimidin-4-yl]-amine; 3-Ethyl-5-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Fluoro-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Fluoro-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; (4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-methanol; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; [2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 5-{6-[2-(4,5-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(5-Chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Ethylamino-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethylamino-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethylamino-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 3-Ethoxy-5-{6-[2-(4-methoxy-2,7-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(5,6,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1-methyl-1H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 3-(4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 1-Ethyl-3-(2-methoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-urea; 2-Chloro-6-ethylamino-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-(6-quinolin-6-yl-pyrimidin-4-yl)-amine; 2-Ethylamino-6-fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 4-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Chloro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; {6-[4-(2-Amino-5-methyl-thiazol-4-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-propyl-2,3-dihydro-isoindol-1-one; 2-Cyclobutoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethylamino-6-fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 4-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Butoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-(4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 2-(4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethyl-benzenesulfonamide; {6-[4-(5-Amino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-(4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-2-carboxylic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methyl-1H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; 2-Cyclopentyloxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Butoxy-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(5,7-difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propoxy-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; [2-(5-Chloro-7-methyl-[1,3]dioxolo[4,5-e]indol-6-yl)-ethyl]-{6-[3-ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; {6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 3-(4-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 2-Chloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(1 H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(1 H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; 2-Chloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; 2-Chloro-4-{6-[2-(6,7-difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-pyrazin-2-yl-phenyl)-pyrimidin-4-yl]-amine; 6-{6-[2-(7-Chloro-5-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,2-dihydro-indazol-3-one; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-1-methyl-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; and 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-hydroxy-thiophene-2-carboxylic acid. 29) Further compounds according to embodiment 1) are selected from the following compounds: [6-(4-Amino-phenyl)-pyrimidin-4-yl]-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [6-(4-Amino-phenyl)-pyrimidin-4-yl]-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 3-Chloro-5-{6-[2-(2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethyl-5-{6-[2-(2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; [6-(1H-Benzoimidazol-5-yl)-pyrimidin-4-yl]-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [6-(2,3-Dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [6-(2,3-Dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [6-(2,3-Dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; (4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methyl-phenyl)-methanol; (2-Chloro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; (2-Fluoro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 3-Chloro-5-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; (2-Fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 3-Chloro-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzamide; 4-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-benzoic acid; (2-Fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 2-Chloro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; (4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-methanol; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methyl-benzoic acid; (4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methyl-phenyl)-methanol; 2-Ethylsulfanyl-4-{6-[2-(2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2,6-Difluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenol; 4-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-benzoic acid; (2-Methoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzenesulfonic acid; (4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-urea; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzamide; 3-Chloro-5-{6-[2-(4,6-dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 4-{6-[2-(4-Chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 3-Fluoro-5-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Fluoro-5-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Fluoro-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-thiophene-2-carboxylic acid; [6-(1H-Benzoimidazol-5-yl)-pyrimidin-4-yl]-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indazol-6-yl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-6-yl)-pyrimidin-4-yl]-amine; 5-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,3-dihydro-indol-2-one; 5-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-isoindol-1-one; [2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(2,3-dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-6-yl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(2H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,3-dihydro-2H-benzo[d]imidazol-2-one ; {6-[4-(1H-Imidazol-2-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-pyrazol-1-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indazol-6-yl)-pyrimidin-4-yl]-amine; 5-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-2,3-dihydro-isoindol-1-one; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-isoindol-1-one; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,3-dihydro-indol-2-one; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-6-yl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(4-isoxazol-3-yl-phenyl)-pyrimidin-4-yl]-amine; 5-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-2,3-dihydro-isoindol-1-one; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-thiazol-4-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(4H-[1,2,4]triazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; (4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-methanol; 2-Chloro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(4-Chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methyl-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzenesulfonic acid; 3-Ethoxy-5-{6-[2-(6-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 2-Isobutyl-4-{6-[2-(2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-benzoic acid; 4-{6-[2-(5,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methyl-benzoic acid; (2-Ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 4-{6-[2-(7-Fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; (2-Ethoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 4-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-benzoic acid; 2-Chloro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methyl-benzoic acid; (4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-urea; (6-Isoquinolin-7-yl-pyrimidin-4-yl)-[2-(2-methyl-indol-1-yl)-ethyl]-amine; 4-{6-[2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 4-{6-[2-(7-Chloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 4-{6-[2-(2-Cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methyl-benzenesulfonamide; 4-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(4,7-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-methylsulfanyl-benzoic acid; 2-Chloro-4-{6-[2-(4,7-dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methylsulfanyl-benzoic acid; 4-{6-[2-(7-Chloro-4-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(5,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(7-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(7-Fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(4,7-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(4,7-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(7-Chloro-4-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(7-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-6-ethyl-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(2-Cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(5,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 4-{6-[2-(4-Chloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-cyclopropyl-benzoic acid; 2-Ethylamino-4-{6-[2-(6-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Cyclopropyl-4-{6-[2-(4,7-difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Cyclopropyl-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Cyclopropyl-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(1-methyl-1H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(5-methyl-1H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 6-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indazole-3-carboxylic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; 3-(4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; {6-[4-(3-Amino-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; 3-(4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 3-Ethyl-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-isoindol-1-one; 2-Ethyl-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-isoindol-1-one; 5-(4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-isoxazol-3-ol; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-oxazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-2,3-dihydro-isoindol-1-one; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methyl-2,3-dihydro-isoindol-1-one; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-isothiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; 3-Ethyl-5-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-isoindol-1-one; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(4H-[1,2,4]triazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 4-{6-[2-(4-Fluoro-2,7-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 4-{6-[2-(4-Chloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 2-Amino-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylsulfanyl-benzoic acid; 2-Fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methyl-benzoic acid; 2-Ethyl-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethyl-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(4,7-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylsulfanyl-benzoic acid; 2,6-Dichloro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethyl-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethyl-thiophene-2-carboxylic acid; 2,6-Dichloro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-benzoic acid; 4-{6-[2-(4-Chloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 5-{6-[2-(6,7-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-Ethyl-5-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 4-{6-[2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 2-Ethylamino-4-{6-[2-(4-fluoro-2,7-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethylamino-4-{6-[2-(7-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 2-Ethoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethoxy-4-{6-[2-(6-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 3-Ethoxy-5-{6-[2-(7-fluoro-5-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-benzoic acid; 4-{6-[2-(2,5-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Ethyl-6-fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(4-Chloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(7-Chloro-5-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylsulfanyl-benzoic acid; 4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 5-{6-[2-(6,7-Dichloro-5-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methyl-benzoic acid; 4-{6-[2-(4,5-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(4,6-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(4-Chloro-6-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(4-Chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethoxy-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethyl-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-6-methyl-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-benzoic acid; 2-Ethyl-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2,6-Dichloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2,6-Dichloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(5-Chloro-7-methyl-[1,3]dioxolo[4,5-e]indol-6-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-benzoic acid; 2-Cyclopropyl-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; {6-[4-(2-Amino-5-methyl-thiazol-4-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; {6-[3-FLuoro-4-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(3-methyl-[1,2,4]oxadiazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(3-methyl-pyrazol-1-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[4-(2-Amino-5-methyl-thiazol-4-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 3-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 5-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-propyl-2,3-dihydro-isoindol-1-one; 5-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-2,3-dihydro-isoindol-1-one; 3-Ethyl-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-isoindol-1-one; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indole-7-carboxylic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(3-methyl-butyl)-benzoic acid; 4-{6-[2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(5,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(7-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propylsulfanyl-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(7-chloro-4,5-difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methylsulfanyl-benzoic acid; 4-{6-[2-(7-Chloro-4-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propyl-benzoic acid; 4-{6-[2-(7-Chloro-5-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 2-Chloro-4-{6-[2-(7-chloro-4-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Isobutyl-4-{6-[2-(6-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-5-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methyl-benzoic acid; 4-{6-[2-(6-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-difluoromethoxy-benzoic acid; 4-{6-[2-(7-Chloro-4,5-difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(2-methyl-1H-benzoimidazol-5-yl)-pyrimidin-4-yl]-amine; 2-Chloro-6-ethylamino-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Cyclopropyl-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-(6-quinolin-6-yl-pyrimidin-4-yl)-amine; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propylamino-benzoic acid; 2,6-Difluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzenesulfonamide; 2-Chloro-6-ethylamino-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; {6-[4-(5-Amino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-[2-(2-methyl-indol-1-yl)-ethyl]-amine; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-6-methyl-benzoic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methyl-benzoic acid; 4-{6-[2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(3-methyl-butyl)-benzoic acid; 4-{6-[2-(4,7-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutylsulfanyl-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-(6-quinoxalin-6-yl-pyrimidin-4-yl)-amine; 2-Cyclopropyl-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-(6-isoquinolin-7-yl-pyrimidin-4-yl)-amine; 1-(2-Fluoro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-cyclopropanecarboxylic acid; {6-[4-(5-Methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-[2-(2-methyl-indol-1-yl)-ethyl]-amine; 6-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indazole-3-carboxylic acid; 6-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indazole-3-carboxylic acid; 2,6-Dichloro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(4-Cyano-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-nitro-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethylamino-6-fluoro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethylamino-4-{6-[2-(4-fluoro-7-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-methoxy-benzoic acid; 4-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethoxy-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-6-methyl-benzoic acid; 2-Ethoxy-6-fluoro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(4,5-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(4,7-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isopropylsulfanyl-benzoic acid; 2-Chloro-4-{6-[2-(7-chloro-5-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Isobutyl-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-6-fluoro-benzoic acid; 2-Chloro-6-ethoxy-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-6-ethoxy-4-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethoxy-6-fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethoxy-6-fluoro-4-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethyl-6-fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 4-{6-[2-(7-Chloro-5-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylsulfanyl-benzoic acid; 2-Ethoxy-4-{6-[2-(4,5,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-4-{6-[2-(4-chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-ethoxy-benzoic acid; 4-{6-[2-(4-Cyano-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 4-{6-[2-(7-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-cyclobutylsulfanyl-benzoic acid; 2-Cyclobutylsulfanyl-4-{6-[2-(4,7-dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(5-Chloro-7-methyl-[1,3]dioxolo[4,5-e]indol-6-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(5-Chloro-7-methyl-[1,3]dioxolo[4,5-e]indol-6-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 3-Isobutyl-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-isoindol-1-one; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-pyrrolidin-1-yl-benzoic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-2,3-dihydro-isoindol-1-one; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isobutyl-2,3-dihydro-isoindol-1-one; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-pyrrolidin-1-yl-benzoic acid; 2-Butoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-lsobutoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-6-ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethoxy-6-fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 2-Chloro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Fluoro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-benzoic acid; 4-{6-[2-(7-Chloro-4,5-difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isopropylsulfanyl-benzoic acid; 2-Isobutyl-4-{6-[2-(4,6,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Isobutyl-4-{6-[2-(4,5,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Isobutyl-4-{6-[2-(4-methoxy-2,7-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-benzoic acid; 4-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-difluoromethoxy-benzoic acid; 4-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propyl-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propyl-benzoic acid; 2-Chloro-4-{6-[2-(7-chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Chloro-4-{6-[2-(6-chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Fluoro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 2-Butoxy-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-6-propyl-benzoic acid; 2-Ethoxy-6-ethyl-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(7-Chloro-5-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-(4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-2-carboxylic acid; 2-(4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; 4-(4-{6-[2-(4,6-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-2-carboxylic acid; 2-(4-{6-[2-(4,6-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; {6-[4-(2-Amino-oxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-isoxazol-3-yl-phenyl)-pyrimidin-4-yl]-amine; 4-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-thiazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(3-methyl-3H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(3-methyl-3H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-oxazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-pyridin-2-yl-phenyl)-pyrimidin-4-yl]-amine; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-methyl-2-trifluoromethyl-benzenesulfonamide; 5-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-3-methyl-isoxazole-4-carboxylic acid; 2-Difluoromethoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-6-ethoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Difluoromethoxy-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Difluoromethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Fluoro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Butoxy-4-{6-[2-(7-chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 2-Ethoxy-6-ethyl-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-6-propyl-benzoic acid; 2-Chloro-6-propoxy-4-{6-[2-(4,6,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 4-{6-[2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propoxy-benzoic acid; 2-Difluoromethoxy-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-difluoromethoxy-benzoic acid; 2-Difluoromethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 3-Ethoxy-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-trifluoromethyl-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-[5-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-oxazol-2-yl]-propionic acid; 2-(4-Fluoro-phenoxy)-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(4-fluoro-phenoxy)-benzoic acid; {6-[3-Ethoxy-5-fluoro-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; {6-[3-Ethoxy-5-fluoro-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[3-ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(2-methyl-indol-1-yl)-ethyl]-amine; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[3-methoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[3-Ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(2-methyl-indol-1-yl)-ethyl]-amine; 3-(4-{6-[2-(4,6-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 3-(4-{6-[2-(4,5,7-Trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[3-methoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[3-methoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; 2-Chloro-6-isobutoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; 2-Chloro-4-{6-[2-(6,7-difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; [6-(1H-Indol-5-yl)-pyrimidin-4-yl]-[2-(2-methyl-indol-1-yl)-ethyl]-amine; [2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; 3-(4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-3-oxo-propionitrile; 3-(4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-3-oxo-propionitrile; 3-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-3-oxo-propionitrile; 3-(4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-3-oxo-propionitrile; [2-(2-Methyl-indol-1-yl)-ethyl]-{6-[4-(3-methyl-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(3-methyl-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(3-methyl-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-{6-[2-(7-Chloro-5-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 2-Chloro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(3-pyrazol-1-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-pyridin-2-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-(6-isoquinolin-7-yl-pyrimidin-4-yl)-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(3-pyrazol-1-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(4-pyridin-2-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-(6-isoquinolin-7-yl-pyrimidin-4-yl)-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-(6-quinolin-6-yl-pyrimidin-4-yl)-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(4-methyl-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(4-methyl-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [6-(3H-Benzotriazol-5-yl)-pyrimidin-4-yl]-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]triazol-1-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-isoxazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-isoxazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-isoxazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; {6-[3-Methoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(2-methyl-indol-1-yl)-ethyl]-amine; [2-(4,7-Difluoro-2-methyl-indol-1-yl)-ethyl]-{6-[3-methoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-thiazol-2-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(4-methoxy-pyrimidin-2-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-pyrimidin-2-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methoxy-pyrimidin-2-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(4-methyl-thiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(6-methoxy-pyrazin-2-yl)-phenyl]-pyrimidin-4-yl}-amine; 6-(4-(6-((2-(6-fluoro-4-methoxy-2-methyl-1H-indol-1-yl)ethyl)amino)pyrimidin-4-yl)phenyl)-N,N-dimethylpyrimidin-4-amine; [2-(2-Methyl-indol-1-yl)-ethyl]-[6-(4-thiazol-2-yl-phenyl)-pyrimidin-4-yl]-amine; 2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-methoxy-benzamide; 2,N-Diethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzamide; N-Benzyloxy-2-ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzamide; 2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-(2-hydroxy-ethoxy)-benzamide; 2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-isopropoxy-benzamide; 2-Ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-(2-hydroxy-ethoxy)-benzamide; 6-{6-[2-(2-Methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,2-dihydro-indazol-3-one; 6-{6-[2-(2-Methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzo[d]isoxazol-3-one; 4-{6-[2-(2,7-Dichloro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(2,4-Dichloro-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(2-Chloro-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(4-Bromo-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-[4-(4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazol-2-yl]-acetamide; 2-[4-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazol-2-yl]-acetamide; 4-{6-[2-(5,6-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(7-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-((E)-2-fluoro-vinylsulfanyl)-benzoic acid; 5-{6-[2-(2-Methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(1H-tetrazol-5-yl)-phenol; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid ethyl ester; [2-(2-Methyl-indol-1-yl)-ethyl]-{6-[5-(1H-tetrazol-5-yl)-thiophen-2-yl]-pyrimidin-4-yl}-amine; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-propylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 4-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazol-2-ol; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-3-ol; and 2-Ethoxy-4-{6-[2-(4-fluoro-2,7-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid. 30) In addition to the most preferred compounds listed in embodiment 27), further most preferred compounds compounds according to embodiment 1) are selected from the following compounds: Ethanesulfonic acid (5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-amide; 7-Fluoro-1-(2-{6-[4-(1H-imidazol-4-yl)-3-methoxy-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-(2-{6-[4-(5-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-1H-indole-2-carbonitrile; 1-(2-{6-[3-Ethoxy-4-((5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(2,5-Dimethyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(3-Ethyl-4-hydroxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(1,5-Dimethyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(1,2-Dimethyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-(2-{6-[4-((5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-(2-{6-[5-(3-hydroxy-oxetan-3-yl)-4-methoxy-thiophen-2-yl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(2-Cyclopropyl-1-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-phenoxy)-acetic acid; 7-Fluoro-1-(2-{6-[4-(3H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 3-(2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-[1,2,4]oxadiazol-5(4H)-one; 7-Fluoro-1-(2-{6-[4-(3-oxo-2,3-dihydro-1,2,4-oxadiazol-5-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-(2,2,2-trifluoro-ethoxy)-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-phenoxy)-acetic acid; 3-(2-Ethoxy-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-[1,2,4]oxadiazol-5(4H)-one; 2-butoxy-6-chloro-4-(6-((2-(7-fluoro-4-methoxy-2-methyl-1H-indol-1-yl)ethyl-1,1,2,2-d4)amino)pyrimidin-4-yl)benzoic acid; 5-{6-[2-(7-Chloro-5-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-(2,2,2-trifluoro-ethoxy)-thiophene-2-carboxylic acid; 2-(2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-propionic acid; 5-{6-[2-(2-Cyano-3-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 7-Fluoro-1-(2-{6-[4-(3-hydroxy-isoxazol-5-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; N-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenyl)-oxalamic acid; 7-Fluoro-1-(2-{6-[4-(3-hydroxy-isoxazol-5-yl)-3-methoxy-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 1-(2-{6-[4-(2-Cyclopropyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(6-Chloro-7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 7-Fluoro-1-{2-[6-(4-hydroxy-3-trifluoromethoxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(3-Chloro-4-hydroxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(4,6-Dichloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; 5-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Butoxy-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-phenol; 3-Ethoxy-5-{6-[2-(3-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-3-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (2-Ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid; 2-Butoxy-4-{6-[2-(6,7-difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-(2-Ethoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-[1,2,4]oxadiazol-5(4H)-one; 5-{6-[2-(4,6-Dichloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-5,6-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; (4-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 1-{2-[6-(3-Ethoxy-4-hydroxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid amide; 5-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 2-Butoxy-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-fluoro-benzoic acid; 2-Butoxy-6-chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propoxy-benzoic acid; 5-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 2-Chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; (4-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; (4-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-difluoromethoxy-benzoic acid; 7-Fluoro-4-methoxy-1-{2-[6-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-ethylsulfanyl-benzoic acid; 7-Fluoro-4-methoxy-1-(2-{6-[4-(3H-[1,2,3]triazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-1H-indole-2-carbonitrile; 3-(3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-ethoxy-phenoxy)-propionic acid; 3-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-propionic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-3-fluoro-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzenesulfonamide; 1-(2-{6-[3-Ethoxy-4-(3H-[1,2,3]triazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 3-(5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophen-2-yl)-propionic acid; 7-Fluoro-1-(2-{6-[4-(2-hydroxy-3,4-dioxo-cyclobut-1-enyl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenyl)-oxo-acetic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isopropylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isopropylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propyl-benzoic acid; 5-{6-[2-(2-Cyano-5,7-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-6,7-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; (4-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6,7-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 2-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indole-5-carboxylic acid; 7-Fluoro-1-{2-[6-(1 H-indol-2-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1 H-indole-2-carbonitrile; 2-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indole-5-carboxylic acid methyl ester; 7-Fluoro-1-(2-{6-[4-(2-hydroxy-ethoxy)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-{2-[6-(1 H-indol-6-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1 H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-1-{2-[6-(1 H-indol-3-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1 H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; N-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-formamide; 7-Fluoro-4-methoxy-1-{2-[6-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-1-{2-[6-(1H-indazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 1-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-3-ethyl-urea; 1-{2-[6-(1H-Benzoimidazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(3H-Benzotriazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 1-{2-[6-(3-Ethoxy-4-formyl-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-{2-[6-(1 H-indol-5-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1 H-indole-2-carbonitrile; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-benzoic acid methyl ester; 7-Fluoro-1-{2-[6-(4-hydroxy-3-trifluoromethyl-phenyl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-ethoxy-benzoic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-3-carboxylic acid ethyl ester; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 4-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 3-(5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophen-2-yl)-propionic acid; 3-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-propionic acid; (E)-3-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-acrylic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 3-Chloro-5-{6-[2-(4-chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Chloro-5-{6-[2-(4-chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carbonyl)-methanesulfonamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid ethylamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid dimethylamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid (2-hydroxy-ethyl)-amide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid isopropylamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid (2-methoxy-ethyl)-amide; 5-(6-((2-(2-cyano-7-fluoro-4-methoxy-1H-indol-1-yl)ethyl)amino)pyrimidin-4-yl)-3-ethoxy-N-sulfamoylthiophene-2-carboxamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid hydroxyamide; (3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-methanol; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-isopropoxy-thiazole-5-carboxylic acid; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-methoxy-thiazole-5-carboxylic acid; 4-Ethoxy-2-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiazole-5-carboxylic acid; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-propoxy-thiazole-5-carboxylic acid; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-isobutyl-thiazole-5-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid carboxymethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid dimethylcarbamoylmethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid butyryloxymethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid ethoxycarbonyloxymethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid 2-dimethylamino-ethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid phenyl ester; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-propynoic acid ethyl ester; {6-[4-Ethoxy-5-(1H-tetrazol-5-yl)-thiophen-2-yl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-hydroxy-thiophene-2-carboxamidine; 3-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-[1,2,4]oxadiazol-5(4H)-one; 5-{6-[2-(3,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[5-(2H-tetrazol-5-yl)-4-trifluoromethyl-thiophen-2-yl]-pyrimidin-4-yl}-amine; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-hydroxy-3-trifluoromethyl-thiophene-2-carboxamidine; 3-(5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophen-2-yl)-[1,2,4]oxadiazol-5(4H)-one; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-N-hydroxy-benzamide; 5-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-isoxazol-3-ol; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-pyridin-2-yl-thiophene-2-carboxylic acid; [6-(4-Ethylamino-thiophen-2-yl)-pyrimidin-4-yl]-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [6-(4-Ethylamino-thiophen-2-yl)-pyrimidin-4-yl]-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [6-(4-Ethylamino-thiophen-2-yl)-pyrimidin-4-yl]-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; N-Ethyl-N-(5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-3-yl)-formamide; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-formamide; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-propionamide; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-3-hydroxy-propionamide; (3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-urea; and 5-{6-[2-(2-Cyano-3,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid. 31) In addition to the preferred compounds listed in embodiment 28), further preferred compounds according to embodiment 1) are selected from the following compounds: 1-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-ethanol; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid methyl ester; 7-Fluoro-4-methoxy-1-{2-[6-(2-trifluoromethyl-pyridin-4-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-methoxy-benzoic acid; 7-Fluoro-4-methoxy-1-{2-[6-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-(2-methoxy-ethyl)-benzamide; 7-Fluoro-1-[2-(6-imidazo[1,2-a]pyridin-6-yl-pyrimidin-4-ylamino)-ethyl]-4-methoxy-1 H-indole-2-carbonitrile; 7-Fluoro-1-{2-[6-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(2-Cyclopropyl-pyridin-4-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(2-Azetidin-1-yl-pyridin-4-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 7-Fluoro-4-methoxy-1-{2-[6-(2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(3-methoxy-1H-indazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; (4-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; 5-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-5,6-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 5-{6-[2-(7-Chloro-5-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Butoxy-4-{6-[2-(6-chloro-7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(4,7-Dichloro-5-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (2-Ethoxy-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid; 5-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4,6-Dichloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4,6-Dichloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; [6-(3-Ethoxy-4-oxazol-2-yl-phenyl)-pyrimidin-4-yl]-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; and (2-Chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenoxy)-acetic acid.

[0080] The compounds of formula (I) according to embodiments 1) to 31) and their pharmaceutically acceptable salts can be used as medicaments, e.g. in the form of pharmaceutical compositions for enteral (such especially oral e.g. in form of a tablet or a capsule) or parenteral administration (including topical application or inhalation).

[0081] The production of the pharmaceutical compositions can be effected in a manner which will be familiar to any person skilled in the art (see for example Remington, The Science and Practice of Pharmacy, 21st Edition (2005), Part 5, "Pharmaceutical Manufacturing" [published by Lippincott Williams & Wilkins]) by bringing the described compounds of formula (I) or their pharmaceutically acceptable salts, optionally in combination with other therapeutically valuable substances, into a galenical administration form together with suitable, non-toxic, inert, therapeutically compatible solid or liquid carrier materials and, if desired, usual pharmaceutical adjuvants.

[0082] The present invention also relates to a method for the prevention / prophylaxis or treatment of a disease or disorder mentioned herein comprising administering to a subject a pharmaceutically active amount of a compound of formula (I) according to embodiments 1) to 31).

[0083] In a preferred embodiment of the invention, the administered amount is comprised between 1 mg and 2000 mg per day, particularly between 5 mg and 1000 mg per day, more particularly between 25 mg and 500 mg per day, especially between 50 mg and 200 mg per day.

[0084] Whenever the word "between" is used to describe a numerical range, it is to be understood that the end points of the indicated range are explicitly included in the range. For example: if a temperature range is described to be between 40 °C and 80 °C, this means that the end points 40 °C and 80 °C are included in the range; or if a variable is defined as being an integer between 1 and 4, this means that the variable is the integer 1, 2, 3, or 4.

[0085] Unless used regarding temperatures, the term "about" placed before a numerical value "X" refers in the current application to an interval extending from X minus 10% of X to X plus 10% of X, and preferably to an interval extending from X minus 5% of X to X plus 5% of X. In the particular case of temperatures, the term "about" placed before a temperature "Y" refers in the current application to an interval extending from the temperature Y minus 10 °C to Y plus 10 °C, and preferably to an interval extending from Y minus 5 °C to Y plus 5 °C.

[0086] For avoidance of any doubt, if compounds are described as useful for the prevention / prophylaxis or treatment of certain diseases, such compounds are likewise suitable for use in the preparation of a medicament for the prevention / prophylaxis or treatment of said diseases. Likewise, such compounds are also suitable in a method for the prevention / prophylaxis or treatment of such diseases, comprising administering to a subject (mammal, especially human) in need thereof, an effective amount of such compound.

[0087] The compounds of formula (I) according to embodiments 1) to 31) are useful for the prevention / prophylaxis or treatment of disorders relating to the EP2 and / or EP4 receptors.

[0088] Certain compounds of formula (I) according to embodiments 1) to 31) exhibit their biological activity as modulators of the prostaglandin 2 receptors EP2 and / or EP4 in a biological environment, (i.e. in the presence of one or more enzymes capable of breaking a covalent bond linked to a carbonyl group such as an amidase, an esterase or any suitable equivalent thereof capable of removing a prodrug group from a carboxylic acid group.

[0089] Diseases or disorders relating to the EP2 and / or EP4 receptors are especially cancer (notably melanoma including metastatic melanoma; lung cancer including non-small cell lung cancer; bladder cancer including urinary bladder cancer, urothelial cell carcinoma; renal carcinomas including renal cell carcinoma, metastatic renal cell carcinoma, metastatic renal clear cell carcinoma; gastro-intestinal cancers including colorectal cancer, metastatic colorectal cancer, familial adenomatous polyposis (FAP), oesophageal cancer, gastric cancer, gallbladder cancer, cholangiocarcinoma, hepatocellular carcinoma, and pancreatic cancer such as pancreatic adenocarcinoma or pancreatic ductal carcinoma; endometrial cancer; ovarian cancer; cervical cancer; neuroblastoma; prostate cancer including castrate-resistant prostate cancer; brain tumors including brain metastases, malignant gliomas, glioblastoma multiforme, medulloblastoma, meningiomas; breast cancer including triple negative breast carcinoma; oral tumors; nasopharyngeal tumors; thoracic cancer; head and neck cancer; leukemias including acute myeloid leukemia, adult T-cell leukemia; carcinomas; adenocarcinomas; thyroid carcinoma including papillary thyroid carcinoma; choriocarcinoma; Ewing's sarcoma; osteosarcoma; rhabdomyosarcoma; Kaposi's sarcoma; lymphoma including Burkitt's lymphoma, Hodgkin's lymphoma, MALT lymphoma; multiple myelomas; and virally induced tumors; especially melanoma; lung cancer; bladder cancer; renal carcinomas; gastro-intestinal cancers; endometrial cancer; ovarian cancer; cervical cancer; and neuroblastoma); as well as further diseases or disorders relating to the EP2 and / or EP4 receptors such as: pain (notably inflammatory pain and painful menstruation); endometriosis; autosomal dominant polycystic kidney disease; acute ischemic syndromes in atherosclerotic patients; pneumonia; and neurodegenerative diseases including amyotrophic lateral sclerosis, stroke; Parkinson disease, Alzheimer's disease and HIV associated dementia; and EP2 and / or EP4 antagonists may further be used to control female fertility.

[0090] Further diseases or disorders relating to the EP2 and / or EP4 receptors are autoimmune disorders such as especially multiple sclerosis, rheumatoid arthritis and osteoarthritis; and osteoporosis.

[0091] The compounds of formula (I) according to any one of embodiments 1) to 31) are in particular useful as therapeutic agents for the prevention / prophylaxis or treatment of a cancer. They can be used as single therapeutic agents or in combination with one or more chemotherapy agents and / or radiotherapy and / or targeted therapy. Such combined treatment may be effected simultaneously, separately, or over a period of time.

[0092] The invention, thus, also relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier material, and: a compound of formula (I) according to any one of embodiments 1) to 31); and one or more cytotoxic chemotherapy agents.

[0093] The invention, thus, further relates to a kit comprising a pharmaceutical composition, said composition comprising a pharmaceutically acceptable carrier material, and: a compound of formula (I) according to any one of embodiments 1) to 31); and instructions how to use said pharmaceutical composition for the prevention / prophylaxis or the treatment of a cancer, in combination with chemotherapy and / or radiotherapy and / or targeted therapy.

[0094] The terms "radiotherapy" or "radiation therapy" or "radiation oncology", refer to the medical use of ionizing radiation in the prevention / prophylaxis (adjuvant therapy) and / or treatment of cancer; including external and internal radiotherapy.

[0095] The term "targeted therapy" refers to the prevention / prophylaxis (adjuvant therapy) and / or treatment of cancer with one or more anti-neoplastic agents such as small molecules or antibodies which act on specific types of cancer cells or stromal cells. Some targeted therapies block the action of certain enzymes, proteins, or other molecules involved in the growth and spread of cancer cells. Other types of targeted therapies help the immune system kill cancer cells (immunotherapies); or inhibit angiogenesis, the growth and formation of new blood vessels in the tumor; or deliver toxic substances directly to cancer cells and kill them. An example of a targeted therapy which is in particular suitable to be combined with the compounds of the present invention is immunotherapy, especially immunotherapy targeting the progammed cell death receptor 1 (PD-1 receptor) or its ligand PD-L1 (Zelenay et al., 2015, Cell 162, 1-14; Yongkui Li et al., Oncoimmunology 2016, 5(2):e1074374).

[0096] When used in combination with the compounds of formula (I), the term "targeted therapy" especially refers to agents such as: a) Epidermal growth factor receptor (EGFR) inhibitors or blocking antibodies (for example Gefitinib, Erlotinib, Afatinib, Icotinib, Lapatinib, Panitumumab, Zalutumumab, Nimotuzumab, Matuzumab and Cetuximab); b) RAS / RAF / MEK pathway inhibitors (for example Vemurafenib, Sorafenib, Dabrafenib,GDC-0879, PLX-4720, LGX818, RG7304, Trametinib (GSK1120212), Cobimetinib (GDC-0973 / XL518), Binimetinib (MEK162, ARRY-162), Selumetinib (AZD6244)); c) Aromatase inhibitors (for example Exemestane, Letrozole, Anastrozole, Vorozole, Formestane, Fadrozole); d) Angiogenesis inhibitors, especially VEGF signalling inhibitors such as Bevacuzimab (Avastin), Ramucirumab , Sorafenib or Axitinib; e) Immune Checkpoint inhibitors (for example: anti-PD1 antibodies such as Pembrolizumab (Lambrolizumab, MK-3475), Nivolumab, Pidilizumab (CT-011), AMP-514 / MED10680, PDR001, SHR-1210; REGN2810, BGBA317; fusion proteins targeting PD-1 such as AMP-224; small molecule anti-PD1 agents such as for example compounds disclosed in WO2015 / 033299, WO2015 / 044900 and WO2015 / 034820; anti-PD1L antibodies, such as BMS-936559, atezolizumab (MPDL3280A, RG7446), MEDI4736, avelumab (MSB0010718C), durvalumab (MEDI4736); anti-PDL2 antibodies, such as AMP224; anti-CTLA-4 antibodies, such as ipilimumab, tremilmumab; anti-Lymphocyte-activation gene 3 (LAG-3) antibodies, such as BMS-986016, IMP701, MK-4280, ImmuFact IMP321; anti T cell immunoglobulin mucin-3 (TIM-3) antibodies, such as MBG453; anti-CD137 / 4-1BB antibodies, such as BMS-663513 / urelumab, PF-05082566; anti T cell immunoreceptor with Ig and ITIM domains (TIGIT) antibodies, such as RG6058 (anti-TIGIT, MTIG7192A); f) Vaccination approaches (for example dendritic cell vaccination, peptide or protein vaccination (for example with gp100 peptide or MAGE-A3 peptide); g) Re-introduction of patient derived or allogenic (non-self) cancer cells genetically modified to secrete immunomodulatory factors such as granulocyte monocyte colony stimulating factor (GMCSF) gene-transfected tumor cell vaccine (GVAX) or Fms-related tyrosine kinase 3 (Flt-3) ligand gene-transfected tumor cell vaccine (FVAX),or Toll like receptor enhanced GM-CSF tumor based vaccine (TEGVAX); h) T-cell based adoptive immunotherapies, including chimeric antigen receptor (CAR) engineered T-cells (for example CTL019); i) Cytokine or immunocytokine based therapy (for example Interferon alpha, interferon beta, interferon gamma, interleukin 2, interleukin 15); j) Toll-like receptor (TLR) agonists (for example resiquimod, imiquimod, glucopyranosyl lipid A, CpG oligodesoxynucleotides); k) Thalidomide analogues (for example Lenalidomide, Pomalidomide); l) Indoleamin-2,3-Dioxgenase (IDO) and / or Tryptophane-2,3-Dioxygenase (TDO) inhibitors (for example RG6078 / NLG919 / GDC-0919; Indoximod / 1MT (1-methyltryptophan), INCB024360 / Epacadostat, PF-06840003 (EOS200271), F001287); m) Activators of T-cell co-stimulatory receptors (for example anti-OX40 / CD134 (Tumor necrosis factor receptor superfamily, member 4, such as RG7888 (MOXR0916), 9B12; MEDI6469, GSK3174998, MEDI0562), anti OX40-Ligand / CD252; anti-glucocorticoid-induced TNFR family related gene (GITR) (such as TRX518, MEDI1873, MK-4166, BMS-986156), anti-CD40 (TNF receptor superfamily member 5) antibodies (such as Dacetuzumab (SGN-40), HCD122, CP-870,893, RG7876, ADC-1013, APX005M, SEA-CD40); anti-CD40-Ligand antibodies (such as BG9588); anti-CD27 antibodies such as Varlilumab); n) Molecules binding a tumor specific antigen as well as a T-cell surface marker such as bispecific antibodies (for example RG7802 targeting CEA and CD3) or antibody fragments, antibody mimetic proteins such as designed ankyrin repeat proteins (DARPINS), bispecific T-cell engager (BITE, for example AMG103, AMG330); o) Antibodies or small molecular weight inhibitors targeting colony-stimulating factor-1 receptor (CSF-1R) (for example Emactuzumab (RG7155), Cabiralizumab (FPA-008), PLX3397); p) Agents targeting immune cell check points on natural killer cells such as antibodies against Killer-cell immunoglobulin-like receptors (KIR) for example Lirilumab (IPH2102 / BMS-986015); q) Agents targeting the Adenosine receptors or the ectonucleases CD39 and CD73 that convert ATP to Adenosine, such as MEDI9447 (anti-CD73 antibody), PBF-509; CPI-444 (Adenosine A2a receptor antagonist).

[0097] When used in combination with the compounds of formula (I), immune checkpoint inhibitors such as those listed under d), and especially those targeting the progammed cell death receptor 1 (PD-1 receptor) or its ligand PD-L1, are preferred.

[0098] The term "chemotherapy" refers to the treatment of cancer with one or more cytotoxic anti-neoplastic agents ("cytotoxic chemotherapy agents"). Chemotherapy is often used in conjunction with other cancer treatments, such as radiation therapy or surgery. The term especially refers to conventional cytotoxic chemotherapeutic agents which act by killing cells that divide rapidly, one of the main properties of most cancer cells. Chemotherapy may use one drug at a time (single-agent chemotherapy) or several drugs at once (combination chemotherapy or polychemotherapy). Chemotherapy using drugs that convert to cytotoxic activity only upon light exposure is called photochemotherapy or photodynamic therapy.

[0099] The term "cytotoxic chemotherapy agent" or "chemotherapy agent" as used herein refers to an active anti-neoplastic agent inducing apoptosis or necrotic cell death. When used in combination with the compounds of formula (I), the term especially refers to conventional cytotoxic chemotherapy agents such as: a) alkylating agents (for example mechlorethamine, chlorambucil, cyclophosphamide, ifosfamide, streptozocin, carmustine, lomustine, melphalan, dacarbazine, temozolomide, fotemustine, thiotepa or altretamine; especially cyclophosphamide, carmustine, melphalan, dacarbazine, or temozolomide); b) platinum drugs (especially cisplatin, carboplatin or oxaliplatin); c) antimetabolite drugs (for example 5-fluorouracil, folic acid / leucovorin, capecitabine, 6-mercaptopurine, methotrexate, gemcitabine, cytarabine, fludarabine or pemetrexed; especially 5-fluorouracil, folic acid / leucovorin, capecitabine, methotrexate, gemcitabine or pemetrexed); d) anti-tumor antibiotics (for example daunorubicin, doxorubicin, epirubicin, idarubicin, actinomycin-D, bleomycin, mitomycin-C or mitoxantrone; especially doxorubicin); e) mitotic inhibitors (for example paclitaxel, docetaxel, ixabepilone, vinblastine, vincristine, vinorelbine, vindesine or estramustine; especially paclitaxel, docetaxel, ixabepilone or, vincristine); or f) topoisomerase inhibitors (for example etoposide, teniposide, topotecan, irinotecan, diflomotecan or elomotecan; especially etoposide or irinotecan).

[0100] When used in combination with the compounds of formula (I), preferred cytotoxic chemotherapy agents are the above-mentioned alkylating agents (notably fotemustine,cyclophosphamide, ifosfamide, carmustine, dacarbazine and prodrugs thereof such as especially temozolomide or pharmaceutically acceptable salts of these compounds; in particular temozolomide); mitotic inhibitors (notably paclitaxel, docetaxel, ixabepilone,; or pharmaceutically acceptable salts of these compounds; in particular paclitaxel); platinum drugs (notably cisplatin, oxaliplatin and carboplatin); as well etoposide and gemcitabine.

[0101] Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. Combined modality chemotherapy is the use of drugs with other cancer treatments, such as radiation therapy or surgery. Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. This type of chemotherapy is used for curative intent. Consolidation chemotherapy is the given after remission in order to prolong the overall disease free time and improve overall survival. The drug that is administered is the same as the drug that achieved remission. Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is used. Combination chemotherapy involves treating a patient with a number of different drugs simultaneously. The drugs differ in their mechanism and side effects. The biggest advantage is minimising the chances of resistance developing to any one agent. Also, the drugs can often be used at lower doses, reducing toxicity. Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. It is also given to cancers with a high risk of micrometastatic disease. Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). It can be used when there is little evidence of cancer present, but there is risk of recurrence. It is also useful in killing any cancerous cells that have spread to other parts of the body. These micrometastases can be treated with adjuvant che...

Claims

1. A compound of formula (I) wherein (R1)n represents one, two or three optional substituents on the indole ring, wherein said substituents are independently selected from (C1-3)alkyl, (C1-3)alkoxy, halogen, (C1-3)fluoroalkyl, (C1-3)fluoroalkoxy, or cyano; or two R1 together form a group -O-CH2-O-, and the remaining R1, if present, represents halogen; R2 represents (C1-4)alkyl, halogen, or cyano; R3 represents hydrogen, methyl or trifluoromethyl; R4a and R4b independently represent hydrogen, methyl, or R4a and R4b together with the carbon atom to which they are attached represent a cycloprop-1,1-diyl group; R5a and R5b independently represent hydrogen, methyl, or R5a and R5b together with the carbon atom to which they are attached represent a cycloprop-1,1-diyl group; Ar1 represents • phenyl, or 5- or 6-membered heteroaryl; wherein said phenyl or 5- or 6-membered heteroaryl independently is mono-, di- or tri-substituted, wherein the substituents are independently selected from • (C1-6)alkyl; • (C1-4)alkoxy; • (C1-3)fluoroalkyl, wherein said (C1-3)fluoroalkyl is optionally substituted with hydroxy; • (C1-3)fluoroalkoxy; • halogen; • cyano; • (C3-6)cycloalkyl, wherein said (C3-6)cycloalkyl is unsubstituted or mono-substituted with amino; • (C4-6)cycloalkyl containing a ring oxygen atom, wherein said (C4-6)cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy; • (C3-6)cycloalkyl-oxy; • hydroxy; • nitro; • -B(OH)2; • 2,2,2-trifluoro-1,1 -dihydroxy-ethyl; • -X1-CO-RO1, wherein ▪ X1 represents a direct bond, (C1-3)alkylene, -O-(C1-3)alkylene-*, -NH-(C1-3)alkylene-*, -S-CH2-*, -CF2-, -CH=CH-, -C=C-, -NH-CO-*, -CO-, or (C3-5)cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-RO1 group; and ▪ RO1 represents • -OH; • -O-(C1-4)alkyl; • -NH-SO2-RS3 wherein RS3 represents (C1-4)alkyl, (C3-6)cycloalkyl wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C3-6)cycloalkyl-(C1-3)alkylene wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C1-3)fluoroalkyl, phenyl, or-NH2; • -O-phenyl; • -O-CH2-CO-RO4, wherein RO4 represents hydroxy, or (C1-4)alkoxy, or -N[(C1-4)alkyl]2: • -O-CH2-O-CO-RO5, wherein RO5 represents (C1-4)alkyl or (C1-4)alkoxy; • -O-CH2-CH2-N[(C1-4)alkyl]2; or • (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; • -CO-CH2-CN; • -CO-CH2-OH; • -CO-H; • • • 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; • hydroxy-(C1-4)alkyl; • dihydroxy-(C2-4)alkyl; • hydroxy-(C2-4)alkoxy; • (C1-4)alkoxy-(C2-4)alkoxy; • -(CH2)m-NRN1RN2, wherein m represents the integer 0 or 1; and wherein ▪ RN1 and RN2 independently represent hydrogen, (C1-4)alkyl, (C1-4)alkoxy-(C2-4)alkyl, (C3-6)cycloalkyl, (C2-3)fluoroalkyl, -or -SO2-(C1-4)alkyl; ▪ or RN1 independently represents hydrogen or (C1-4)alkyl, and RN2 independently represents -CO-H, -CO-(C1-3)alkyl, -CO-(C1-3)alkylene-OH, or -CO-O-(C1-3)alkyl; ▪ or RN1 and RN2 together with the nitrogen to which they are attached form a 4-, 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; • -CO-NRN3RN4 wherein RN3 and RN4 independently represent hydrogen, (C1-4)alkyl, hydroxy-(C2-4)alkyl, (C1-3)alkoxy-(C2-4)alkyl, dimethylamino-(C2-4)alkyl, (C1-4)alkoxy, hydroxy-(C2-4)alkoxy, benzyloxy, or hydroxy; • -NH-CO-NRN5RN6 wherein RN5 and RN6 independently represent hydrogen or (C1-4)alkyl; • -SO2-RS1 wherein RS1 represents hydroxy, (C1-4)alkyl, or -NRN7RN8 wherein RN7 and RN8 independently represent hydrogen or (C1-3)alkyl: • -S-RS2 wherein RS2 represents (C1-4)alkyl, (C3-6)cycloalkyl, or 2-fluoro-vinyl; • 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl, or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl; • phenyl-oxy, wherein the phenyl is optionally mono-substituted with halogen; • benzooxazol-2-yl; or • -(CH2)p-HET, wherein p represents the integer 0 or 1; and wherein HET represents a 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C1-4)alkyl, (C1-4)alkoxy, -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C3-5)cycloalkyl, or -NRN9RN10 wherein RN9 and RN10 independently represent hydrogen or (C1-3)alkyl: • or Ar1 represents 8- to 10-membered bicyclic heteroaryl; wherein said 8- to 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, di- or tri-substituted, wherein the substituents are independently selected from (C1-4)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkyl; (C1-3)fluoroalkoxy; halogen; cyano; hydroxy, or -(C0-3)alkylene-COORO2 wherein RO2 represents hydrogen or (C1-4)alkyl; • or Ar1 represents 8- to 10-membered partially aromatic fused bicyclic heterocyclyl comprising one to four heteroatoms independently selected from nitrogen, oxygen and sulfur; wherein said 8- to 10-membered heterocyclyl is linked to the rest of the molecule at the aromatic ring moiety; wherein said 8- to 10-membered heterocyclyl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo, (C1-6)alkyl, and -(C0-3)alkylene-COORO3 wherein RO3 represents hydrogen or (C1-3)alkyl: or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1; wherein R3 represents hydrogen; or a pharmaceutically acceptable salt thereof.

3. A compound according to claims 1 or 2; wherein • R4a and R4b both represent hydrogen; and • R5a and R5b both represent hydrogen; or a pharmaceutically acceptable salt thereof.

4. A compound according to any one of claims 1 to 3; wherein Ar1 represents • phenyl, or 5- or 6-membered heteroaryl; wherein said phenyl or 5- or 6-membered heteroaryl independently is mono-, di- or tri-substituted; wherein one of said substituents is selected from • (C1-4)alkoxy; • (C1-3)fluoroalkyl, wherein said (C1-3)fluoroalkyl is unsubstituted or mono-substituted with hydroxy; • (C3-6)cycloalkyl, wherein said (C3-6)cycloalkyl is unsubstituted or mono-substituted with amino; • (C4-6)cycloalkyl containing a ring oxygen atom, wherein said (C4-6)cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy; • hydroxy; • -B(OH)2; • 2,2,2-trifluoro-1,1-dihydroxy-ethyl; • -X1-CO-RO1, wherein ▪ X1 represents a direct bond, (C1-3)alkylene, -O-(C1-3)alkylene-*, -NH-(C1-3)alkylene-*, -S-CH2-*, -CF2-, -CH=CH-, -C=C-, -NH-CO-*, -CO-, or (C3-5)cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-RO1 group; and ▪ RO1 represents • -OH; • -O-(C1-4)alkyl; • -NH-SO2-RS3 wherein RS3 represents (C1-4)alkyl, (C3-6)cycloalkyl wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C3-6)cycloalkyl-(C1-3)alkylene wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C1-3)fluoroalkyl, phenyl, or-NH2; • -O-phenyl; • -O-CH2-CO-RO4, wherein RO4 represents hydroxy, or (C1-4)alkoxy, or -N[(C1-4)alkyl]2; • -O-CH2-O-CO-RO5, wherein RO5 represents (C1-4)alkyl or (C1-4)alkoxy; • -O-CH2-CH2-N[(C1-4)alkyl]2; or • (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; • -CO-CH2-CN; • -CO-CH2-OH; • -CO-H; • • • 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; • hydroxy-(C1-4)alkyl; • dihydroxy-(C2-4)alkyl; • hydroxy-(C2-4)alkoxy; • (C1-4)alkoxy-(C2-4)alkoxy; • -(CH2)m-NRN1RN2, wherein m represents the integer 0 or 1; and wherein ▪ RN1 and RN2 independently represent hydrogen, (C1-4)alkyl, (C1-4)alkoxy-(C2-4)alkyl, (C3-6)cycloalkyl, (C2-3)fluoroalkyl, -or -SO2-(C1-4)alkyl; ▪ or RN1 independently represents hydrogen or (C1-4)alkyl, and RN2 independently represents -CO-H, -CO-(C1-3)alkyl, -CO-(C1-3)alkylene-OH, or -CO-O-(C1-3)alkyl; ▪ or RN1 and RN2 together with the nitrogen to which they are attached form a 4-, 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; • -CO-NRN3RN4 wherein RN3 and RN4 independently represent hydrogen, (C1-4)alkyl, hydroxy-(C2-4)alkyl, (C1-3)alkoxy-(C2-4)alkyl, dimethylamino-(C2-4)alkyl, (C1-4)alkoxy, hydroxy-(C2-4)alkoxy, benzyloxy, or hydroxy; • -NH-CO-NRN5RN6 wherein RN5 and RN6 independently represent hydrogen or (C1-4)alkyl; • -SO2-RS1 wherein RS1 represents hydroxy, (C1-4)alkyl, or -NRN7RN8 wherein RN7 and RN8 independently represent hydrogen or (C1-3)alkyl; • 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl; • benzooxazol-2-yl; or • -(CH2)p-HET, wherein p represents the integer 0 or 1; and wherein HET represents a 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C1-4)alkyl, (C1-4)alkoxy, -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C3-5)cycloalkyl, or -NRN9RN10 wherein RN9 and RN10 independently represent hydrogen or (C1-3)alkyl; and the remaining one or two of said substituents, if present, is / are independently selected from • (C1-6)alkyl; • (C1-4)alkoxy; • (C1-3)fluoroalkyl; • (C1-3)fluoroalkoxy: • halogen; • (C3-6)cycloalkyl; • (C3-6)cycloalkyl-oxy; • hydroxy; • nitro; • -(CH2)m-NRN1RN2, wherein m represents the integer 0 or 1; and wherein RN1 and RN2 independently represent hydrogen, (C1-4)alkyl, (C1-4)alkoxy-(C2-4)alkyl, (C3-6)cycloalkyl, (C2-3)fluoroalkyl, -or -SO2-(C1-4)alkyl; or RN1 and RN2 together with the nitrogen to which they are attached form a 5- or 6-membered saturated ring optionally containing one ring oxygen or ring sulfur atom, wherein said ring is unsubstituted, or mono-substituted with oxo on a ring carbon atom, or disubstituted with oxo on a ring sulfur atom; • -S-RS2 wherein RS2 represents (C1-4)alkyl, (C3-6)cycloalkyl, or 2-fluoro-vinyl; or • phenyl-oxy, wherein the phenyl is optionally mono-substituted with halogen; • or Ar1 represents 8- to 10-membered bicyclic heteroaryl; wherein said 8- to 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, di- or tri-substituted, wherein the substituents are independently selected from (C1-4)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkyl; halogen; and -(C0-3)alkylene-COORO2 wherein RO2 represents hydrogen or (C1-4)alkyl; • or Ar1 represents 8- to 10-membered partially aromatic fused bicyclic heterocyclyl comprising one to four heteroatoms independently selected from nitrogen, oxygen and sulfur; wherein said 8- to 10-membered heterocyclyl is linked to the rest of the molecule at the aromatic ring moiety; wherein said 8- to 10-membered heterocyclyl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo, (C1-6)alkyl, and -(C0-3)alkylene-COORO3 wherein RO3 represents hydrogen or (C1-3)alkyl; or a pharmaceutically acceptable salt thereof.

5. A compound according to any one of claims 1 to 3; wherein Ar1 represents • a phenyl group of the structure (Ar-IV): wherein • Rp represents; (C4-6)cycloalkyl containing a ring oxygen atom, wherein said (C4-6)cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with fluoro, hydroxy, or methoxy; hydroxy; -X1-CO-RO1, wherein X1 represents a direct bond, (C1-3)alkylene, -O-(C1-3)alkylene-*, -NH-(C1-3)alkylene-*, -S-CH2-*, -CF2-, -CH=CH-, -C=C-, -NH-CO-*, -CO-, or (C3-5)cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-RO1 group; and RO1 represents ▪ -OH; ▪ -O-(C1-4)alkyl; ▪ -NH-SO2-RS3 wherein RS3 represents (C1-4)alkyl, (C3-6)cycloalkyl wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C3-6)cycloalkyl-(C1-3)alkylene wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C1-3)fluoroalkyl, phenyl, or-NH2; ▪ -O-CH2-CO-RO4, wherein RO4 represents hydroxy, or (C1-4)alkoxy, or -N[(C1-4)alkyl]2: ▪ -O-CH2-O-CO-RO5, wherein RO5 represents (C1-4)alkyl or (C1-4)alkoxy; ▪ -O-CH2-CH2-N[(C1-4)alkyl]2; or ▪ (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; -CO-H; 2-hydroxy-3,4-dioxo-cyclobut-1-enyl; -NRN1RN2, wherein ▪ RN1 independently represents hydrogen or (C1-4)alkyl, and RN2 independently represents -CO-H, -CO-(C1-3)alkyl, or -CO-(C1-3)alkylene-OH; -CO-NRN3RN4 wherein RN3 and RN4 independently represent hydrogen, (C1-4)alkyl, hydroxy-(C2-4)alkyl, (C1-3)alkoxy-(C2-4)alkyl, or hydroxy; -NH-CO-NRN5RN6 wherein RN5 and RN6 independently represent hydrogen or (C1-4)alkyl; 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl; HET, wherein HET represents a 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C1-4)alkyl, (C1-4)alkoxy, -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C3-5)cycloalkyl, or -NRN9RN10 wherein RN9 and RN10 independently represent hydrogen or (C1-3)alkyl; • Rm1 represents (C1-6)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkyl; (C1-3)fluoroalkoxy; halogen; (C3-6)cycloalkyl; (C3-6)cycloalkyl-oxy; -NRN1RN2, wherein RN1 and RN2 independently represent hydrogen, (C1-4)alkyl, or (C3-6)cycloalkyl; or -S-RS2 wherein RS2 represents (C1-4)alkyl, (C3-6)cycloalkyl, or 2-fluoro-vinyl; and • Rm2 represents hydrogen, fluoro, or chloro; • or Rp represents hydrogen; Rm1 represents 1 H-pyrazol-1-yl; or -X1-COOH, wherein X1 represents a direct bond, (C1-3)alkylene, or -O-(C1-3)alkylene-*, wherein the asterisks indicate the bond that is linked to the -COOH group; and Rm2 represents hydrogen, (C1-4)alkoxy; or -S-(C1-4)alkyl; • or Ar1 represents a 5-membered heteroaryl group of the structure (Ar-II): wherein in (Ar-II) the ring A represents a thiophenyl or a thiazolyl ring; wherein • R7 represents 3-hydroxy-oxetan-3-yl; hydroxy; 2,2,2-trifluoro-1,1-dihydroxy-ethyl; -X1-CO-RO1, wherein X1 represents a direct bond, (C1-3)alkylene, -O-(C1-3)alkylene-*, -NH-(C1-3)alkylene-*, -S-CH2-*, -CF2-, -CH=CH-, -C=C-, -NH-CO-*, -CO-, or (C3-5)cycloalkylene; wherein the asterisks indicate the bond that is linked to the -CO-RO1 group; and RO1 represents ▪ -OH; ▪ -O-(C1-4)alkyl; ▪ -NH-SO2-RS3 wherein RS3 represents (C1-4)alkyl, (C3-6)cycloalkyl wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C3-6)cycloalkyl-(C1-3)alkylene wherein the (C3-6)cycloalkyl optionally contains a ring oxygen atom, (C1-3)fluoroalkyl, phenyl, or-NH2; ▪ -O-phenyl; ▪ -O-CH2-CO-RO4, wherein RO4 represents hydroxy, or (C1-4)alkoxy, or -N[(C1-4)alkyl]2; ▪ -O-CH2-O-CO-RO5, wherein RO5 represents (C1-4)alkyl or (C1-4)alkoxy; ▪ -O-CH2-CH2-N[(C1-4)alkyl]2; or ▪ (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyloxy-; -CO-CH2-OH; -CO-H; hydroxy-(C1-4)alkyl; -NRN1RN2, wherein ▪ RN1 and RN2 independently represent hydrogen, (C1-4)alkyl, or (C3-6)cycloalkyl; ▪ or RN1 independently represents hydrogen or (C1-4)alkyl, and RN2 independently represents -CO-H, -CO-(C1-3)alkyl, or-CO-(C1-3)alkylene-OH; -CO-NRN3RN4 wherein RN3 and RN4 independently represent hydrogen, (C1-4)alkyl, hydroxy-(C2-4)alkyl, (C1-3)alkoxy-(C2-4)alkyl, dimethylamino-(C2-4)alkyl, (C1-4)alkoxy, hydroxy-(C2-4)alkoxy, benzyloxy, or hydroxy; -NH-CO-NRN5RN6 wherein RN5 and RN6 independently represent hydrogen or (C1-4)alkyl; 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl; or HET, wherein HET represents a 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C1-4)alkyl, (C1-4)alkoxy, -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, (C3-5)cycloalkyl, or -NRN9RN10 wherein RN9 and RN10 independently represent hydrogen or (C1-3)alkyl; • and (R6)n represents one optional substituent independently selected from (C1-6)alkyl: (C1-4)alkoxy; (C1-3)fluoroalkyl; (C1-3)fluoroalkoxy; halogen; (C3-6)cycloalkyl; (C3-6)cycloalkyl-oxy; hydroxy; pyridinyl; and -NRN1RN2, wherein RN1 and RN2 independently represent hydrogen, (C1-4)alkyl, or (C3-6)cycloalkyl; • or Ar1 represents 9- or 10-membered bicyclic heteroaryl; wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from (C1-4)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkyl; (C1-3)fluoroalkoxy; halogen; cyano; hydroxy, or -(C0-3)alkylene-COORO2 wherein RO2 represents hydrogen or (C1-4)alkyl; • or Ar1 represents a group of the structure (Ar-III): wherein ring (B) represents a non-aromatic 5- or 6-membered ring fused to the phenyl group, wherein ring (B) comprises one or two heteroatoms independently selected from nitrogen and oxygen; wherein said ring (B) independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo, (C1-6)alkyl, and -(C0-3)alkylene-COORO3 wherein RO3 represents hydrogen or (C1-3)alkyl: or a pharmaceutically acceptable salt thereof.

6. A compound according to any one of claims 1 to 3; wherein • Ar1 represents a phenyl group selected from: a) or b) or c) or d) • or Ar1 represents a thiophenyl group selected from: a) or b) c) • or Ar1 represents a thiazoyl group selected from: • or Ar1 represents 9- or 10-membered bicyclic heteroaryl selected from a) or b) • or Ar1 represents a group selected from: a) or b) and or a pharmaceutically acceptable salt thereof.

7. A compound according to any one of claims 1 to 6; wherein the group represents wherein R2 represents methyl, chloro, or cyano; and R13 represents hydrogen; and • R14, R15, R16, and R17 independently represent the following: R14 represents hydrogen, methyl, ethyl, methoxy, bromo, chloro, fluoro, trifluoromethyl, trifluoromethoxy, or cyano; R15 represents hydrogen, methyl, methoxy, chloro, fluoro; R16 represents hydrogen, methoxy, or fluoro; and R17 represents hydrogen, methyl, methoxy, chloro, fluoro, or cyano; wherein at least one of R14, R15, R16, and R17 represents hydrogen; • or R14 and R15 together form a group -O-CH2-O-, R16 represents hydrogen and R17 represents hydrogen or halogen; or R2 represents (C1-3)alkyl, halogen, or cyano; and R13 represents fluoro; and • R14, R15, R16, and R17 independently represent the following: R14 represents hydrogen, methyl, ethyl, methoxy, bromo, chloro, fluoro, trifluoromethyl, trifluoromethoxy, or cyano; R15 represents hydrogen, methyl, methoxy, chloro, fluoro; R16 represents hydrogen, methoxy, or fluoro; and R17 represents hydrogen, methyl, methoxy, chloro, fluoro, or cyano; wherein at least two of R14, R15, R16, and R17 represent hydrogen. or a pharmaceutically acceptable salt thereof.

8. A compound according to any one of claims 1 to 6; wherein the group represents a group selected from the following groups A), B), C), D) and E): A) B) C) D) E) or a pharmaceutically acceptable salt thereof.

9. A compound according to claim 1 which is a compound of Formula (II) wherein R2 represents methyl, chloro, or cyano; and • R14, R15, R16, and R17 independently represent the following: R14 represents methyl, methoxy, halogen, or cyano; R15 represents hydrogen, methyl, chloro, or fluoro; R16 represents hydrogen, or fluoro; and R17 represents hydrogen, chloro, or fluoro; wherein at least one of R15, R16, and R17 represents hydrogen and Ar1 represents • a phenyl group of the structure (Ar-IV): wherein • Rp represents; hydroxy; -COOH; -CO-CH2-CN; -CO-(C1-4)alkoxy; -CO-NH-SO2-RS3 wherein RS3 represents RS3 represents (C1-4)alkyl, (C3-6)cycloalkyl; (C3-6)cycloalkyl-(C1-3)alkyl; (C1-3)fluoroalkyl, phenyl, or -NH2; -X1-CH2-COOH, wherein X1 represents O, or NH; -CO-NRN3RN4 wherein RN3 and RN4 independently represent hydrogen, (C1-4)alkyl, hydroxy-(C2-4)alkyl, (C1-3)alkoxy-(C2-4)alkyl, dimethylamino-(C2-4)alkyl, (C1-4)alkoxy, or hydroxy-(C2-4)alkoxy; -NH-CO-NRN5RN6 wherein RN5 and RN6 independently represent hydrogen or (C1-4)alkyl; -SO2-RS1 wherein RS1 represents hydroxy, (C1-4)alkyl, or -NRN7RN8 wherein RN7 and RN8 independently represent hydrogen or (C1-3)alkyl; 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl; tetrazolyl (especially 1H-tetrazol-5-yl); or 5- or 6-membered heteroaryl selected from oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, or pyrazinyl; wherein said 5- or 6-membered heteroaryl is unsubstituted, or mono- or di-substituted, wherein the substituents are independently selected from (C1-3)alkyl, (C1-3)alkoxy, -COOH, hydroxy, fluoro, 2-amino-2-oxo-ethyl, 2-carboxy-ethyl, or -NRN9RN10 wherein RN9 and RN10 independently represent hydrogen or (C1-3)alkyl; • Rm1 represents hydrogen; (C1-6)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkyl; (C1-3)fluoroalkoxy; halogen; (C3-6)cycloalkyl; (C3-6)cycloalkyl-oxy; hydroxy; -(CH2)m-NRN1RN2, wherein m represents the integer 0 or 1; and wherein RN1 and RN2 independently represent hydrogen, (C1-3)alkyl, or (C2-3)fluoroalkyl; or RN1 and RN2 together with the nitrogen to which they are attached form a pyrrolidinyl ring; or -S-RS2 wherein RS2 represents (C1-4)alkyl, or (C3-6)cycloalkyl; • and Rm2 represents hydrogen; or (C1-6)alkyl; (C1-3)alkoxy; or halogen; • or Ar1 represents a 5-membered heteroaryl group of the structure (Ar-V): wherein in (Ar-V) the ring A represents a thiophenyl or a thiazolyl ring; wherein RA1 represents -COOH; tetrazolyl; -CO-(C1-4)alkoxy; -CO-NH-SO2-RS3 wherein RS3 represents RS3 represents (C1-4)alkyl, (C3-6)cycloalkyl; (C3-6)cycloalkyl-(C1-3)alkyl; (C1-3)fluoroalkyl, phenyl, or -NH2; -X1-CH2-COOH, wherein X1 represents O, or NH; or -CO-NRN3RN4 wherein RN3 and RN4 independently represent hydrogen, (C1-4)alkyl, hydroxy-(C2-4)alkyl, or (C1-3)alkoxy-(C2-4)alkyl; and RA2 represents hydrogen; (C1-6)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkyl; halogen; or hydroxy; • or Ar1 represents 9- or 10-membered bicyclic heteroaryl selected from 1H-indol-5-yl, 1H-indol-4-yl, 1H-indol-6-yl, indazol-6-yl, 1H-benzoimidazol-5-yl, 1H-benzotriazol-5-yl, quinoxalin-6-yl, isoquinolin-7-yl, and quinolin-6-yl; wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from (C1-4)alkyl or -COOH; • or Ar1 represents a group of the structure (Ar-III): wherein ring (B) represents a non-aromatic 5-membered ring fused to the phenyl group, wherein ring (B) comprises one or two nitrogen ring atoms; wherein said ring (B) independently is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from oxo and (C1-6)alkyl; or a pharmaceutically acceptable salt thereof.

10. A compound according claim 1 which is a compound of Formula (III): wherein the group: represents a group selected from the following groups A), B), C), D) and E): A) B) C) D) E) and Ar1 represents • phenyl, or 5-membered heteroaryl selected from thiophenyl and thiazolyl; wherein said phenyl or 5-membered heteroaryl independently is mono-, di- or tri-substituted; wherein one of said substituents is selected from • -X1-CO-RO1, wherein ▪ X1 represents a direct bond, -CH2-CH2-, -O-CH2-*, -NH-CH2-*, -CH=CH-, or -NH-CO-*; wherein the asterisks indicate the bond that is linked to the -CO-RO1 group; and ▪ RO1 represents • -OH; • -O-(C1-4)alkyl; • -NH-SO2-RS3 wherein RS3 represents (C1-3)alkyl, cyclopropyl, or -NH2; • -O-CH2-CO-RO4, wherein RO4 represents hydroxy or (C1-4)alkoxy: or • -O-CH2-O-CO-RO5, wherein RO5 represents (C1-4)alkyl or (C1-4)alkoxy: • -NRN1RN2, wherein RN1 independently represents hydrogen or (C1-3)alkyl, and RN2 represents -CO-H; • 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl, or 3-oxo-2,3-dihydro-[1,2,4]oxadiazol-5-yl; • 1H-tetrazol-5-yl; • 3-hydroxy-isoxazol-5-yl; • imidazolyl, which is unsubstituted, or mono- or di-substituted with methyl; • pyrazolyl; • isoxazolyl, oxazolyl, or thiadiazolyl; wherein said isoxazolyl, oxazolyl, or thiadiazolyl is mono-substituted with -NRN9RN10, wherein RN9 represents hydrogen, and RN10 represents hydrogen or methyl; and the remaining one or two of said substituents (if present) is / are independently selected from • (C1-4)alkyl; • (C1-4)alkoxy; • 2,2,2-trifluoroethoxy; • halogen; • -NRN1RN2, wherein RN1 represents hydrogen, and RN2 represents (C1-3)alkyl; • -S-RS2 wherein RS2 represents (C1-4)alkyl; • or Ar1 represents 8- to 10-membered bicyclic heteroaryl selected from unsubstituted benzimidazol; unsubstituted indazolyl, and indolyl which is unsubstituted or mono-substituted with -COORO2 wherein RO2 represents hydrogen or (C1-4)alkyl; • or Ar1 represents oxo-substituted 8- to 10-membered partially aromatic fused bicyclic heterocyclyl selected from 2-oxo-2,3-dihydro-benzooxazolyl, 3-oxo-2,3-dihydro-1H-indazolyl, 2-oxo-1,2,3,4-tetrahydro-quinazolinyl, 1-oxo-1,2,3,4-tetrahydro-isoquinolinyl; wherein said oxo-substituted heterocyclyl is unsubstituted or mono-substituted on a ring nitrogen atom with (C1-3)alkyl; or a pharmaceutically acceptable salt thereof.

11. A compound according to claim 1 selected from the group consisting of: 3-Chloro-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; [6-(2,3-Dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 3-Ethyl-5-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-Ethyl-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Chloro-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 5-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; {6-[4-(3-Amino-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 3-Ethoxy-5-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(6-Chloro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(7-fluoro-2,5-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethyl-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(4,6-Dichloro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-6-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-6-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 5-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(4,6,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(4,5,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; {6-[4-(3-Amino-isoxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; 5-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Ethylamino-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-2-carboxylic acid; 2-Chloro-4-{6-[2-(6-chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 5-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 1-Ethyl-3-(4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-urea; {6-[4-(2-Amino-oxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; {6-[4-(2-Amino-oxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 2-(4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; 2-(4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 2-Butoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; {6-[4-(2-Amino-oxazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(6,7-difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methylamino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl]}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; {6-[3-Ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[3-ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[3-Ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; {6-[3-Ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; 3-Butoxy-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Butoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-propoxy-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-propoxy-thiophene-2-carboxylic acid; 3-(4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; 6-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,2-dihydro-indazol-3-one; 4-{6-[2-(2-Chloro-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 5-{6-[2-(2-Chloro-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(4-Bromo-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[5-(1H-tetrazol-5-yl)-thiophen-2-yl]-pyrimidin-4-yl}-amine; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-hydroxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 1-(2-{6-[3-Ethoxy-4-(1H-tetrazol-5yyl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; N-(5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-methanesulfonamide; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenoxy)-acetic acid; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid; 5-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; N-(5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-benzenesulfonamide; Propane-2-sulfonic acid (5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-amide; Cyclopropanesulfonic acid (5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-amide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid methylamide; Ethanesulfonic acid (5-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carbonyl)-amide; 7-Fluoro-1-(2-{6-[4-(1 H-imidazol-4-yl)-3-methoxy-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1 H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-(2-{6-[4-(5-methyl-1H-imidazol-4-yl)-phenyl]-pynmidin-4-ylamino}-ethyl)-1H-indole-2-carbonitrile; 1-(2-{6-[3-Ethoxy-4-((5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(2,5-Dimethyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(3-Ethyl-4-hydroxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(1,5-Dimethyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(1,2-Dimethyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-(2-{6-[4-((5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-(2-{6-[5-(3-hydroxy-oxetan-3-yl)-4-methoxy-thiophen-2-yl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 1-(2-{6-[4-(2-Cyclopropyl-1-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-phenoxy)-acetic acid; 7-Fluoro-1-(2-{6-[4-(3H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 3-(2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-[1,2,4]oxadiazol-5(4H)-one; 7-Fluoro-1-(2-{6-[4-(3-oxo-2,3-dihydro-1,2,4-oxadiazol-5-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-(2,2,2-trifluoro-ethoxy)-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-phenoxy)-acetic acid; 3-(2-Ethoxy-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-[1,2,4]oxadiazol-5(4H)-one; 2-butoxy-6-chloro-4-(6-((2-(7-fluoro-4-methoxy-2-methyl-1H-indol-1-yl)ethyl-1,1,2,2-d4)amino)pyrimidin-4-yl)benzoic acid; 5-{6-[2-(7-Chloro-5-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-(2,2,2-trifluoro-ethoxy)-thiophene-2-carboxylic acid; 2-(2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-propionic acid; 5-{6-[2-(2-Cyano-3-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 7-Fluoro-1-(2-{6-[4-(3-hydroxy-isoxazol-5-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; N-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenyl)-oxalamic acid; 7-Fluoro-1-(2-{6-[4-(3-hydroxy-isoxazol-5-yl)-3-methoxy-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 1-(2-{6-[4-(2-Cyclopropyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(6-Chloro-7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 7-Fluoro-1-{2-[6-(4-hydroxy-3-trifluoromethoxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(3-Chloro-4-hydroxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(4,6-Dichloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; 5-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Butoxy-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethoxy-phenol; 3-Ethoxy-5-{6-[2-(3-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-3-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (2-Ethoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid; 2-Butoxy-4-{6-[2-(6,7-difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2,4-Dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 3-(2-Ethoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-[1,2,4]oxadiazol-5(4H)-one; 5-{6-[2-(4,6-Dichloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-5,6-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; (4-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 1-{2-[6-(3-Ethoxy-4-hydroxy-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid amide; 5-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 2-Butoxy-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-fluoro-benzoic acid; 2-Butoxy-6-chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propoxy-benzoic acid; 5-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 2-Chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; (4-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; (4-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-difluoromethoxy-benzoic acid; 7-Fluoro-4-methoxy-1-{2-[6-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-ethylsulfanyl-benzoic acid; 7-Fluoro-4-methoxy-1-(2-{6-[4-(3H-[1,2,3]triazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-1H-indole-2-carbonitrile; 3-(3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-ethoxy-phenoxy)-propionicacid; 3-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-propionic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-3-fluoro-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzenesulfonamide; 1-(2-{6-[3-Ethoxy-4-(3H-[1,2,3]triazol-4-yl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 3-(5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophen-2-yl)-propionic acid; 7-Fluoro-1-(2-{6-[4-(2-hydroxy-3,4-dioxo-cyclobut-1-enyl)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenyl)-oxo-acetic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isopropylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isopropylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propyl-benzoic acid; 5-{6-[2-(2-Cyano-5,7-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-6,7-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; (4-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenylamino)-acetic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylsulfanyl-benzoic acid; 4-{6-[2-(2-Cyano-6,7-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(2-Cyano-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 2-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indole-5-carboxylic acid; 7-Fluoro-1-{2-[6-(1H-indol-2-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 2-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1H-indole-5-carboxylic acid methyl ester; 7-Fluoro-1-(2-{6-[4-(2-hydroxy-ethoxy)-phenyl]-pyrimidin-4-ylamino}-ethyl)-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-{2-[6-(1H-indol-6-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-1 -{2-[6-(1 H-indol-3-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1 H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; N-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-formamide; 7-Fluoro-4-methoxy-1-{2-[6-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-1 -{2-[6-(1 H-indazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1 H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1 H-pyrrolo[2,3-b]pyridin-3-yl)-pyrimidin-4-ylamino]-ethyl}-1 H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 1-(4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-3-ethyl-urea; 1-{2-[6-(1H-Benzoimidazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(3H-Benzotriazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 1-{2-[6-(3-Ethoxy-4-formyl-phenyl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 7-Fluoro-1-{2-[6-(1H-indol-5-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-benzoic acid methyl ester; 7-Fluoro-1-{2-[6-(4-hydroxy-3-trifluoromethyl-phenyl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1H-indole-2-carbonitrile; 3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-ethoxy-benzoic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-3-carboxylic acid ethyl ester; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 4-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 3-(5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-isopropoxy-thiophen-2-yl)-propionic acid; 3-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-propionic acid; (E)-3-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-acrylic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methylamino-benzoic acid; 3-Chloro-5-{6-[2-(4-chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Chloro-5-{6-[2-(4-chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carbonyl)-methanesulfonamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid ethylamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid dimethylamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid (2-hydroxy-ethyl)-amide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid isopropylamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid (2-methoxy-ethyl)-amide; 5-(6-((2-(2-cyano-7-fluoro-4-methoxy-1H-indol-1-yl)ethyl)amino)pyrimidin-4-yl)-3-ethoxy-N-sulfamoylthiophene-2-carboxamide; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid hydroxyamide; (3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-methanol; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-isopropoxy-thiazole-5-carboxylic acid; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-methoxy-thiazole-5-carboxylic acid; 4-Ethoxy-2-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiazole-5-carboxylic acid; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-propoxy-thiazole-5-carboxylic acid; 2-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-4-isobutyl-thiazole-5-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid carboxymethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid dimethylcarbamoylmethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid butyryloxymethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid ethoxycarbonyloxymethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid 2-dimethylamino-ethyl ester; 5-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid phenyl ester; (4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-propynoic acid ethyl ester; {6-[4-Ethoxy-5-(1H-tetrazol-5-yl)-thiophen-2-yl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-hydroxy-thiophene-2-carboxamidine; 3-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-[1,2,4]oxadiazol-5(4H)-one; 5-{6-[2-(3,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[5-(2H-tetrazol-5-yl)-4-trifluoromethyl-thiophen-2-yl]-pyrimidin-4-yl}-amine; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-hydroxy-3-trifluoromethyl-thiophene-2-carboxamidine; 3-(5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophen-2-yl)-[1,2,4]oxadiazol-5(4H)-one; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-N-hydroxy-benzamide; 5-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-isoxazol-3-ol; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-pyridin-2-yl-thiophene-2-carboxylic acid; [6-(4-Ethylamino-thiophen-2-yl)-pyrimidin-4-yl]-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [6-(4-Ethylamino-thiophen-2-yl)-pyrimidin-4-yl]-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [6-(4-Ethylamino-thiophen-2-yl)-pyrimidin-4-yl]-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; N-Ethyl-N-(5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-3-yl)-formamide; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-formamide; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-propionamide; N-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-3-hydroxy-propionamide; (3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-urea; and 5-{6-[2-(2-Cyano-3,7-difluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; or a pharmaceutically acceptable salt thereof.

12. A compound according to claim 1 selected from the group consisting of: 3-Chloro-5-{6-[2-(4-chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Chloro-5-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; (2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; 5-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-methyl-thiophene-2-carboxylic acid; [6-(2,3-Dihydro-1H-indol-5-yl)-pyrimidin-4-yl]-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; [2-(4-Methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(2H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[4-(1H-Imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(2-methyl-1H-benzoimidazol-5-yl)-pyrimidin-4-yl]-amine; 3-Ethyl-5-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Fluoro-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Fluoro-5-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; (4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-methoxy-phenyl)-methanol; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-methanol; [2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 5-{6-[2-(4,5-Difluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 5-{6-[2-(5-Chloro-7-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Ethylamino-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethylamino-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Ethylamino-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 3-Ethoxy-5-{6-[2-(4-methoxy-2,7-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 3-Ethoxy-5-{6-[2-(5,6,7-trifluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(1-methyl-1H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 3-(4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propyl-benzoic acid; 1-Ethyl-3-(2-methoxy-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-urea; 2-Chloro-6-ethylamino-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-(6-quinolin-6-yl-pyrimidin-4-yl)-amine; 2-Ethylamino-6-fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethylamino-benzoic acid; 2-Chloro-4-{6-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 4-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Chloro-4-{6-[2-(4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; {6-[4-(2-Amino-5-methyl-thiazol-4-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-propyl-2,3-dihydro-isoindol-1-one; 2-Cyclobutoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(2-Cyano-6-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 2-Ethylamino-6-fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-propoxy-benzoic acid; 4-{6-[2-(5,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Fluoro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propyl-benzoic acid; 2-Butoxy-4-{6-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-(4-{6-[2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 2-(4-{6-[2-(4-Methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-4-carboxylic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-trifluoromethyl-benzenesulfonamide; {6-[4-(5-Amino-[1,3,4]thiadiazol-2-yl)-phenyl]-pyrimidin-4-yl}-[2-(6-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; [2-(6,7-Difluoro-2,4-dimethyl-indol-1-yl)-ethyl]-{6-[4-(2-methyl-1H-imidazol-4-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-(4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-thiazole-2-carboxylic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-{6-[4-(5-methyl-1H-pyrazol-3-yl)-phenyl]-pyrimidin-4-yl}-amine; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; 2-Cyclopentyloxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 2-Butoxy-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 4-{6-[2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutoxy-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 4-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-2-methyl-pyrimidin-4-yl}-2-isobutyl-benzoic acid; 2-Chloro-4-{6-[2-(5,7-difluoro-2,4-dimethyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-propoxy-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-fluoro-6-propoxy-benzoic acid; 4-{6-[2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-(2,2,2-trifluoro-ethylamino)-benzoic acid; [2-(5-Chloro-7-methyl-[1,3]dioxolo[4,5-e]indol-6-yl)-ethyl]-{6-[3-ethylamino-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-amine; {6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(7-fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-amine; {6-[3-Ethoxy-4-(1H-tetrazol-5-yl)-phenyl]-pyrimidin-4-yl}-[2-(4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; 3-(4-{6-[2-(6-Chloro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenyl)-4H-[1,2,4]oxadiazol-5-one; 2-Chloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-isobutoxy-benzoic acid; [2-(6-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-2,4-dimethyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; [2-(6,7-Difluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(1-methyl-1H-indol-5-yl)-pyrimidin-4-yl]-amine; 2-Chloro-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; 2-Chloro-4-{6-[2-(6,7-difluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; 2-Chloro-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-6-(2,2,2-trifluoro-ethoxy)-benzoic acid; [2-(6-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-[6-(4-pyrazin-2-yl-phenyl)-pyrimidin-4-yl]-amine; 6-{6-[2-(7-Chloro-5-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-1,2-dihydro-indazol-3-one; 3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-1-methyl-ethylamino]-pyrimidin-4-yl}-thiophene-2-carboxylic acid; 5-{6-[2-(7-Fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-hydroxy-thiophene-2-carboxylic acid; 1-(3-Ethoxy-5-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-thiophen-2-yl)-ethanol; (2-Ethoxy-4-{6-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid methyl ester; 7-Fluoro-4-methoxy-1-{2-[6-(2-trifluoromethyl-pyridin-4-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 3-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-5-methoxy-benzoic acid; 7-Fluoro-4-methoxy-1-{2-[6-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-N-(2-methoxy-ethyl)-benzamide; 7-Fluoro-1-[2-(6-imidazo[1,2-a]pyridin-6-yl-pyrimidin-4-ylamino)-ethyl]-4-methoxy-1 H-indole-2-carbonitrile; 7-Fluoro-1 -{2-[6-(2-oxo-2,3-dihydro-1 H-benzo[d]imidazol-5-yl)-pyrimidin-4-ylamino]-ethyl}-4-methoxy-1 H-indole-2-carbonitrile; 1-{2-[6-(2-Cyclopropyl-pyridin-4-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 1-{2-[6-(2-Azetidin-1-yl-pyridin-4-yl)-pyrimidin-4-ylamino]-ethyl}-7-fluoro-4-methoxy-1H-indole-2-carbonitrile; 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 7-Fluoro-4-methoxy-1-{2-[6-(2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; 7-Fluoro-4-methoxy-1-{2-[6-(3-methoxy-1H-indazol-6-yl)-pyrimidin-4-ylamino]-ethyl}-1H-indole-2-carbonitrile; (4-{6-[2-(4-Chloro-2-cyano-6,7-difluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-phenoxy)-acetic acid; 5-{6-[2-(4-Chloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; 5-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; (4-{6-[2-(2-Cyano-5,6-difluoro-4-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-y}-2-ethoxy-phenylamino)-acetic acid; 5-{6-[2-(7-Chloro-5-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; 2-Butoxy-4-{6-[2-(6-chloro-7-fluoro-4-methoxy-2-methyl-indol-1yl)-ethylamino]-pyrimidin-4-yl}-benzoic acid; 5-{6-[2-(4,7-Dichloro-5-fluoro-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy-thiophene-2-carboxylic acid; (2-Ethoxy-4-{6-[2-(6-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenylamino)-acetic acid; 5-{6-[2-(2-Cyano-7-fluoro-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4,6-Dichloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-trifluoromethyl-thiophene-2-carboxylic acid; 5-{6-[2-(4,6-Dichloro-2-cyano-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-3-fluoro-thiophene-2-carboxylic acid; [6-(3-Ethoxy-4-oxazol-2-yl-phenyl)-pyrimidin-4-yl]-[2-(7-fluoro-4-methoxy-2-methyl-indol-1-yl)-ethyl]-amine; and (2-Chloro-4-{6-[2-(2-cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-phenoxy)-acetic acid; or a pharmaceutically acceptable salt thereof.

13. The compound according to claim 1 which is 4-{6-[2-(2-Chloro-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid, or a pharmaceutically acceptable salt thereof.

14. The compound according to claim 1, which is 4-{6-[2-(2-Cyano-7-fluoro-4-methoxy-indol-1-yl)-ethylamino]-pyrimidin-4-yl}-2-ethoxy-benzoic acid, or a pharmaceutically acceptable salt thereof.

15. A pharmaceutical composition comprising, as active principle, a compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

16. A compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, for use as a medicament.

17. A compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of diseases selected from the group consisting of cancer; pain; endometriosis; autosomal dominant polycystic kidney disease; acute ischemic syndromes in atherosclerotic patients; pneumonia; and neurodegenerative diseases; or for use in the control of female fertility.

18. A compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of a cancer selected from melanoma; lung cancer; bladder cancer; renal carcinomas; gastrointestinal cancers; endometrial cancer; ovarian cancer; cervical cancer; and neuroblastoma.

19. Use of a compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for the prevention or treatment of diseases selected from the group consisting of cancer; pain; endometriosis; autosomal dominant polycystic kidney disease; acute ischemic syndromes in atherosclerotic patients; pneumonia; and neurodegenerative diseases; or for the control of female fertility.

20. A compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, for use in a method of modulating an immune response in a subject having a tumor; wherein said method reactivates the immune system in the tumor of said subject.