PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE

MA43345AUndetermined Publication Date: 2018-08-08F HOFFMANN LA ROCHE & CO AG +1

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Patent Information

Application Number: MA43345
Authority / Receiving Office: MA · MA
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2015-10-02
Filing Date: 2016-09-30
Publication Date: 2018-08-08

Application Information

Patent Timeline

02 Oct 2015

Priority

30 Sep 2016

Application

MA43345

08 Aug 2018

Publication

MA43345A

IPC: C07D487/04; C07K16/18; C07K16/28

CPC: C07K16/2803; C07D519/00; C07K16/32; C07K2317/40; C07K2317/522; C07K2317/567; A61K47/6889; A61K47/6851

Inventors: DRAGOVICH PETER; PILLOW THOMAS

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Abstract

The invention relates to antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug fragment via a disulfide linker, pyrrolobenzodiazepine drug-linker intermediates, and methods of using antibody-drug conjugates.

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