ANTIBODIES AND THEIR METHODS OF USE

Abstract

The present invention relates to multispecific (e.g., bispecific) antibodies that bind specifically to human GITR and / or human OX40, as well as compositions comprising such antibodies. In one specific aspect, the multispecific antibodies bind specifically to human GITR and OX40 and modulate GITR and / or OX40 activity, for example, by enhancing, activating, or inducing GITR and / or OX40 activity, or by reducing, inactivating, or inhibiting GITR and / or OX40 activity. The present invention also relates to methods of treating disorders, such as cancer, by administering a multispecific antibody that binds specifically to human GITR and / or OX40 and modulates GITR and / or OX40 activity, for example, by enhancing, activating, or inducing GITR and / or OX40 activity.The invention also relates to methods of treating autoimmune or inflammatory diseases or disorders by administering a multispecific antibody that binds specifically to human GITR and / or OX40 and modulates GITR and / or OX40 activity, for example by reducing, disabling, or inhibiting GITR and / or OX40 activity.