ARNSI MOLECULES AND THEIR USE IN PROCESSES AND COMPOSITIONS TO INHIBIT NRARP GENE EXPRESSION

Abstract

The invention relates to siRNA molecules and their use in pharmaceutical processes and compositions intended to inhibit the expression of the nrarp gene. The invention also relates to the use of said siRNA molecules in the treatment and / or prevention of a disease or disorder related to neovascularization characterized by increased expression and / or activity of the nrarp gene, said visual disorder being selected from the group comprising age-related macular degeneration (AMD), ischemic retinopathy, diabetic macular edema (DME), proliferative diabetic retinopathy (PDR), diabetic retinal ischemia (DRI), diabetic retinal edema (DRE), and retinopathy of prematurity (ROP), and combinations thereof.