Oligomer extended insulin-fc conjugates

Abstract

This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-fc conjugates. The invention also relates to novel fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.