TEMPERATURE MEASUREMENT DEVICE AND SYSTEM FOR DETERMINING THE DEEP INTERNAL TEMPERATURE OF A HUMAN BEING

Description

Domaine technique de l'invention

[0001] The invention relates to the technical field of devices for measuring and determining the deep internal temperature of human beings.

[0002] For a practitioner, the significant body temperature value is the deep internal temperature, called "core temperature" or "core body temperature" or "CBT" in English. This is the temperature of the internal parts of the body, including the blood and vital organs, such as the heart, liver, kidneys, lungs, etc.

[0003] The deep internal temperature of a human being can be measured by many types of sensors, such as invasive probes intended to equip patients during surgical operations or in certain intensive care units. These include, for example, sensors intended to be located in the esophagus via the oral route, or sensors located in the bladder via the urethral route, or even intravascularly, in particular by catheters equipped with thermal sensors.

[0004] Since these different types of sensors are all invasive, they are difficult to implement and can be the source of vectorization of pathogens in the patient's body and are therefore reserved for specific cases. However, knowledge and monitoring of deep internal temperature is a real need because the creation of a reliable non-invasive device that can be used, particularly in routine hospital care or home care, would open up numerous medical possibilities for establishing a diagnosis, for monitoring protocols or for protocols for adapting medications to patients.

[0005] Thus, research has been conducted to obtain this data without having to measure the deep internal temperature, but by inferring the value of the deep internal temperature from information sent back from different peripheral skin sensors.

[0006] For this estimate or inference to be accurate, such a device must: Take into account that each part of the body is subject to thermoregulation mechanisms which therefore, by extension, give it a temperature measurement different from other parts of the body and from the deep internal temperature; Take into account that the temperature of each site is dependent on the specific local conditions of the site at the time of measurement. Indeed, as soon as the temperature is taken at the periphery, the chosen site is necessarily exposed to very specific conditions.For example, when taking an ear measurement, it is understood that this measurement is impacted if the patient is lying on the ear on which the measurement is taken or if he is not, likewise, when taking the measurement on the arm, it is understood that the measured temperature is different if the arm is covered by a duvet or if it is not; Take into account that the temperature at a measurement site depends on a specific physical or biological activity of the latter at the time of the measurement, which can generate an increase or a decrease in the temperature of the site, potentially independently of the rest of the body. For example, the temperature of the brain and therefore of the head changes according to brain activity, likewise the temperature under the armpit changes according to the activity of the muscle group of the arm.These temperature variations are local but also have an impact on other peripheral sites, nevertheless they are compensated by the body so that they do not directly impact the deep internal temperature. Any physical, mental, digestive activity, and certain biological reactions of the body (local inflammations), is therefore likely to create a misleading local difference.

[0007] In addition to the factors previously discussed which significantly influence the deep internal temperature, the concrete design of the measuring device reveals other necessities which are equally important to take into account: Ergonomic constraints of the worn device: since this is a measuring device worn on the body for potentially several days, care must be taken to ensure that the patient's discomfort is as limited as possible, and that the user feels as little discomfort as possible in the postures and movements he or she performs, and conversely, that these postures and movements do not cause any disruption to the proper functioning of the device; Ergonomic constraints in the procedure for fitting the measuring device: we aim for this operation to be easy and quick, and preferably to preserve the patient's privacy; Difficulty in precision during fitting: it is desirable that the measuring device can be fitted in a precise and repeatable manner in order to provide robust data;Inter-individual morphological and biological variations: if we consider the human being in its extreme diversity and taking into account the different evolutionary stages of the individual, we easily understand that it will be difficult to create a single measuring device adapted to all (from the newborn to the elderly, healthy or pathological, including anorexia and obesity and other comorbidities). However, it is desirable to limit the number of versions, and therefore that each version has the greatest possible adaptability; Etat de la technique

[0008] Document US 2007 / 206655 A1 discloses a dressing incorporating temperature sensors.

[0009] A patch incorporating temperature sensors is known from US 2018 / 184902 A1. Devices for measuring temperature near an armpit are also known from US 2013 / 218022 A1 and WO 2007 / 021751 A2.

[0010] Document US 2011 / 243183 discloses a temperature measuring device in the form of a patch that can be affixed to a person's body, in particular to the forehead, the back of the head, the chest or the middle of the back. This patch is intended to remain in place on the body for long periods, to carry out continuous monitoring of temperature.

[0011] The device described in this document comprises a heat-insulating support including at least two measuring parts. Each measuring part itself comprises a body surface temperature sensor, located on the inner face of the insulating support in contact with the wearer's body, a heat release control layer adjacent to the outer face of the insulating support, an outside air temperature sensor located on the outer face of said layer, and an intermediate temperature sensor at the interface between the insulating support and said layer.

[0012] The measurements obtained by these three temperature sensors (namely: body surface temperature sensor, outside air temperature sensor and intermediate interface temperature sensor) are used for the determination of the deep internal temperature of the wearer.

[0013] This measuring device is not entirely satisfactory. In particular, it provides body surface temperature measurements that are highly dependent on the positioning of the patch on the wearer. In addition, the influence of external parameters affecting the measured temperatures is not optimally taken into account. This results in risks of inaccuracy in the determined deep internal temperature. Objet de l'invention

[0014] In the present disclosure of the invention and in the description of embodiments of the invention, the expressions "configured for" and "arranged for" will be used equivalently.

[0015] The invention aims to remedy all or part of the aforementioned drawbacks by making it possible to determine a deep internal temperature of a human being in a precise, reliable and efficient manner, with a view, ultimately, to improving the monitoring and treatment of patients.

[0016] To this end, and according to a first aspect, the invention relates to a device for measuring a plurality of temperatures with a view to determining a deep internal temperature of a human being according to claim 1.

[0017] According to a general definition of the invention, the measuring device comprises: at least three skin temperature sensors configured to measure a skin temperature of the wearer, the skin temperature sensors being positioned on or in the vicinity of the first face of the measuring device, in a first area of ​​the measuring device, and extending substantially over at least a portion of a peripheral line of the measuring device in the worn configuration; preferably: * the at least three skin temperature sensors are arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors and the wearer's skin;and / or * the first face of the measuring device is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the first face and the skin of the wearer's arm, and the at least three skin temperature sensors are located on this first face while being oriented towards the outside of the device according to the invention; at least one cavity temperature sensor configured to measure a temperature in or in the vicinity of said armpit of the wearer, the cavity temperature sensor being arranged on or in the vicinity of the second face of the measuring device, in a second zone of the measuring device; preferably: * the at least one cavity temperature sensor is arranged to be in direct contact with the armpit of the wearer without an intermediate layer between the at least one cavity temperature sensor and the armpit of the wearer;and / or * the second face of the measuring device is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the second face and the wearer's armpit, and the at least one cavity temperature sensor is located on this second face while being oriented towards the outside of the device according to the invention; said first zone of the skin temperature sensors and said second zone of the cavity temperature sensor(s) being arranged at least partly opposite each other or being substantially adjacent, in projection in a plane orthogonally to said first and second faces.;

[0018] Thus, the measuring device can be wrapped around an arm of the wearer, preferably by matching the shape of this arm. In addition, the positioning of the skin temperature sensors on or near the first face of the device allows them to be applied as close as possible to the skin of the wearer. The invention thus allows the measurement of temperatures in a particularly precise and relevant manner from the different sensors. The location of these different sensors is capable of providing the data necessary for an algorithm to infer the deep internal temperature. In addition, the measuring device can easily remain in place on the arm of the wearer, and it can remain there for the time necessary to take a temperature measurement useful for the diagnosis and long-term monitoring of the patient.

[0019] The number of cavity temperature sensor(s) is preferably less than the number of skin temperature sensors.

[0020] When in place, the measuring device is placed substantially transversely on the wearer's arm, along a peripheral line of the arm. It is specified that the measuring device can be wound over less than one turn, or on the contrary over more than one complete turn, for example by covering itself or by forming a helix around the wearer's arm. For example, in the worn configuration, the measuring device can extend angularly (i.e. around the Z axis of the cylinder) over at least 90°, preferably at least 180°, even better at least 270°, or more than 360°. It is noted that a given measuring device, when worn, can cover a more or less significant angular winding depending on the diameter of the wearer's arm.

[0021] Concretely, the peripheral line corresponds to the winding direction of the measuring device; it can correspond to the length of the measuring device. The peripheral line can typically be located in a plane orthogonal to the axis (Z) of the cylinder formed by the measuring device, that is, in a plane orthogonal to the axis of the wearer's arm.

[0022] Positioning the measuring device on the arm has a number of advantages: it is positioned flush with a thin layer of flesh and fat, including to a lesser extent in obese people, which allows for an undistorted measurement (in other words, a measurement closer to the artery temperature value). In addition, this positioning offers acceptable comfort prospects for the wearer, and is reasonably accessible to a third party for its installation or removal, or to consult the state of the area of ​​the body on which the measuring device is installed, while limiting the invasive nature of these operations for the wearer. Another advantage is that all the sensors are grouped on a single device so that its installation is simple and quick.

[0023] According to a characteristic of the invention, the measuring device is in the form of a cuff to be worn on the arm of a human being, preferably near the axillary hollow for the purpose of obtaining a value of the skin temperature at the level of the brachial artery. This location near the end of the humeral head allows a close proximity between a temperature sensor placed appropriately on the surface of the skin on the inner face of the arm, and a large section of the brachial artery. Advantageously, the cuff can be positioned all around the arm or cover only a portion of the cross-section of the arm, i.e. be only partially wrapped around the wearer's arm.

[0024] In the present invention, the term "skin temperature" means the temperature measured closest to the wearer's skin and preferably the temperature measured on the skin.

[0025] Skin temperature sensors are preferably positioned in an area irrigated by a significant blood flow, the targeted section of which is closest to the heart, and advantageously also close to vital organs, to avoid measuring a temperature that is very dependent on the external temperature.

[0026] By providing that the skin temperature sensors extend over at least a portion of a peripheral line of the measuring device in the worn configuration, it is possible to obtain a plurality of skin temperatures measured in the desired area, in this case around the brachial artery, and as much as possible opposite it. This makes it possible to obtain significant measurements of the temperature of the brachial artery despite variability phenomena disturbing the measurement and which we will describe in the following paragraphs. Obtaining these significant measurements of the temperature of the brachial artery is an important piece of data in the deep internal temperature inference algorithm.

[0027] The advantage of having a measuring device comprising a plurality of skin temperature sensors, more precisely at least three skin temperature sensors, results from the observation that the hottest point of the skin is difficult to locate and likely to move over time. More precisely, the hottest point is initially difficult to locate because interpersonal variability is significant and the temperature differential in question is very small (at this location on the body, the differential between two points on the circumference separated by 1 cm is often less than 0.2°).This hottest point is likely to move over time by different phenomena: by physical activity, in particular biceps activity; by a posture creating a particular geometric situation in relation to a hot or cold source, and in particular in relation to the trunk; finally, by the situation of the wearer's arm which can be vertical, inclined or horizontal, and more or less shaped by an object, which impacts on the conduction and on the internal position of the flesh and the artery and which also directly influences the diffusion of heat coming from the artery through the flesh to the sensor area.

[0028] It is therefore more judicious to have several skin measurement points to have the sequence of temperatures in this area and to analyze their changes over time. This plurality of skin temperature sensors forms a group of skin sensors. In addition, the use of a plurality of sensors makes it possible to cross-reference the skin temperature data and refine it for greater precision and reliability of the data provided to the algorithm for determining the wearer's deep internal temperature. It should be noted that this advantage is obtained without a major increase in price since the temperature sensors are reasonably priced.

[0029] Preferably, at least five skin temperature sensors, for example seven skin temperature sensors, may be provided. Increasing the number of skin temperature sensors increases the accuracy of the temperature determined from skin temperature measurements at different points.

[0030] Preferably, the device continuously collects the temperatures from the skin sensors and, in a first step, the highest measured temperature value among the skin temperature sensors is examined. Indeed, it is observed that it is possible for the highest measured temperature value to be measured by a first sensor at a time t and by a second sensor at a time t+n, in particular when the posture changes or when the wearer's activity varies over time, leading to a specific increase in muscle temperature.

[0031] In a second step, we are interested in checking that the highest temperature is not located among the skin temperature sensors located at extreme positions among the plurality of these sensors. This gives an indication of the good adaptation of the measuring device to the wearer. Thus, if the highest temperature is measured by a skin temperature sensor located at one of the two extreme positions, we can legitimately fear that the highest measurable temperature on the periphery is not measured by any of the sensors in the group of sensors. If such conditions continue, we may well not obtain truly usable data concerning the actual temperature of the artery and therefore not be able to accurately infer the deep internal temperature.It should be noted that poor adaptation of the measuring device to the wearer may in particular be observed following poor positioning of the device, or following slippage of the device during the measurement period, or following extreme exercise or environmental conditions of the device, or following a particular morphology of the wearer. Whatever the cause, if these conditions continue, they are likely to jeopardize the quality of the measurements and may trigger an alert on the device.

[0032] To avoid this, it has also been empirically found that it is preferable for the sensors to cover a sufficient length, for example, at least 50 mm for an adult arm. This limits the risk of finding oneself in a situation where the highest temperature is located on one of the extreme sensors.

[0033] To do this, it has been empirically found that a distance of approximately 10 mm between two adjacent sensors allows the area to be covered correctly and significant errors to be avoided.

[0034] Skin temperature measurement must be highly accurate and reliable. Specialized temperature sensors for human health, incorporating a high-resolution analog-to-digital converter, have been favored.

[0035] In the present invention, the term "cavity temperature" means the temperature in an open cavity of the wearer, in this case the area around an armpit. The cavity temperature is generally and predominantly generated by the wearer's own body, but can also result from other temperature sources such as the body of another person pressed against them, a cooling or heating pocket, the sun, etc. The measuring device according to the invention may comprise a plurality of cavity temperature sensors.

[0036] During operation of the measuring device, there may be heat sources or cold sources that cause a misleading rise or fall in the temperature of the measuring device and the measured temperature.

[0037] Similar sources can also cause an increase or decrease in the temperature of the area of ​​the body around the skin temperature sensors, but this very real increase or decrease in the temperature of this part of the body is often also misleading because it is often only superficial and in reality has little or no effect on the deep internal temperature of the wearer.

[0038] Among these sources, we note first and foremost the trunk of the wearer's body, which can heat or cool the measuring device by conduction, radiation, and possibly convection; any other extracorporeal hot or cold source such as the body of another individual, an item of clothing or a bag, a support on which the wearer is installed (such as a mattress, a railing), the air, a cooling or heating pocket, the sun, etc.

[0039] The use of at least one cavity temperature sensor within the measuring device makes it possible to specifically take into account temperature variations induced by the trunk and more generally to take into account the presence of an external hot source or cold source and to use the measured value in the calculations to take these situations into account and clearly differentiate between a change in external temperature (exogenous) and a change in the temperature of the body itself (endogenous) in order to obtain a more relevant deep internal temperature.

[0040] Furthermore, this measurement of the cavity temperature(s) allows the wearer's situation to be taken into account. Thus, if the cavity temperature is significantly lower than the skin temperature, it is considered that this cavity - here the armpit - is quite open, and therefore that the wearer's limb - here the arm - is quite far from his body or from a body generating heat. Conversely, if the cavity temperature is substantially equal to the skin temperature, it can be deduced that the cavity temperature sensor is a priori close to the wearer's skin. These elements, reduced here to simple data for the explanation, are in essence continuous variables which are important input information for the system's algorithm, and make it possible to determine the deep internal temperature with increased precision and reliability.

[0041] These elements underlie a great deal of complexity. For example, if we imagine the presence of warm pajamas with an almost closed cavity and some perspiration under the armpit, this configuration involves multiple thermal effects: relative insulation of the trunk towards the device by the material of the pajamas, radiation from the armpit towards the device, natural evapotranspiration from the armpit and evaporation through the pajamas, natural convection between the pajamas and the skin, etc. It must be understood that the cavity sensor(s) are intended to provide global information on all of these phenomena in order to correct the measurements made by the skin sensors. They are not intended to be very precise. They operate a corrective.

[0042] The measuring device may include several cavity temperature sensors. These sensors may be at least three in number.

[0043] The accuracy requirement for cavity temperature measurements is lower than for skin temperature measurements. Simpler sensors, such as thermocouples or thermistors, can therefore be chosen, as they are simpler to implement and less expensive.

[0044] By "zone" in which the sensors extend, we mean a surface, preferably substantially rectangular, which encompasses all of the sensors considered, as close as possible to them.

[0045] As indicated previously, the first zone, in which the skin temperature sensors are arranged, and the second zone, in which the cavity temperature sensors are arranged, may be at least partly opposite each other in projection in a plane orthogonal to said first and second faces. This means that, in the direction of the thickness of the measuring device, these first and second zones are completely superimposed, or that there is a partial overlap of these first and second zones.

[0046] Alternatively, the first and second zones may be substantially adjacent in projection in a plane orthogonally to said first and second faces. This means that, seen in said projection plane, the first and second zones are not superimposed but are offset from each other while remaining close to each other, or even being contiguous. By "close", it is meant that the separation distance between the first and second zones according to the projection previously considered (i.e. the length of the smallest segment connecting these projections of the first zone and the second zone) is less than 3 cm, preferably less than 1.5 cm, or even less than 0.8 cm, or even less than 0.5 mm. Seen in said projection plane, the first and second zones may be offset parallel to the (Z) axis, or orthogonally to the (Z) axis, or both.

[0047] According to one possible embodiment, the measuring device is flexible and configured to be able to be deformed, preferably by rolling, between an unworn configuration and the worn configuration. This flexibility allows the measuring device on the one hand to be easily put in place, and on the other hand to properly fit the shape of the arm on which it is placed. The quality of the skin temperature measurements carried out is considerably improved.

[0048] Concretely, due to its flexibility, the measuring device can adapt to different convex or concave shapes of the wearer's body. It can be positioned on arms with prominent biceps, malnourished arms, arms of overweight people, arms of elderly people with thin skin and loss of elasticity, etc. In addition, the measuring device can be positioned on a wearer occupying different positions, for example in a lying position, which can generate folds.

[0049] Preferably, the measuring device is substantially non-extensible, particularly in its longitudinal direction (corresponding to the periphery of the arm), in order to avoid any tourniquet effect on the wearer.

[0050] According to the present invention, the measuring device is configured to be able to be in an unworn configuration in which it is substantially planar. Alternatively, not covered by the present invention, the measuring device could, in its unworn configuration, already be rolled up into a cylinder. The diameter of this cylinder may be larger than in the worn configuration, so additional rolling is necessary to place the measuring device in the worn configuration. Alternatively, the diameter of this cylinder could be smaller than in the worn configuration, provided that there is little or no tightening effect or tourniquet effect generated. Advantageously, the diameter of the measuring device in the worn configuration is adjustable and adjustable to the wearer's arm.

[0051] The measuring device according to the invention further comprises at least one proximal temperature sensor configured to measure a surrounding temperature in the immediate vicinity of the wearer's arm, the proximal temperature sensor(s) being arranged on or in the vicinity of the second face of the measuring device. The proximal temperature sensor - or the center of the group of proximal temperature sensors - may be angularly offset (i.e. around the Z axis of the cylinder) relative to the cavity temperature sensor or the axis of the group of cavity temperature sensors, in the worn configuration of the measuring device, by at least 90°. Preferably, the aforementioned angular offset is approximately 180°. In other words, the proximal temperature sensor is preferably positioned substantially diametrically opposite the at least one cavity temperature sensor, in the worn configuration of the measuring device.Such an arrangement allows for a reliable measurement of proximal temperature, minimizing the influence of the wearer's body heat.

[0052] In the unworn configuration, the distance between a skin temperature sensor and the at least one proximal temperature sensor is greater than 10 cm and preferably less than 20 cm.

[0053] Preferably, the at least one proximal temperature sensor is located on the second face, being oriented towards the outside of the device according to the invention.

[0054] In other words, care should preferably be taken to implant the proximal temperature sensors so that they are placed on the side of the arm which is turned outwards, therefore not turned towards the trunk, while the cavity temperature sensor(s) are placed on the side of the arm which is turned towards the trunk.

[0055] In the present invention, the term "proximal temperature" means the temperature measured in the immediate environment around the measuring device, providing information on the temperature in the immediate environment of the wearer. This temperature varies in particular depending on the losses of calories by the wearer, the intake or loss of calories from the environment and the characteristics of the clothing, sheets, blankets used by the patient.

[0056] The arrangement of the proximal temperature sensor, or the center of the group of proximal temperature sensors, oriented towards the outside of the wearer's body, and substantially opposite the group of cavity temperature sensors, or at least one of the skin temperature sensors, makes it possible to obtain a proximal temperature value subject to a limited influence of the thermal inputs of the wearer's body. Of course, this positioning depends on the circumference of the wearer's arm, the proximal temperature sensor thus being able to be more towards the front (i.e. the stomach) or more towards the rear (i.e. the back) of the wearer's body.

[0057] Furthermore, when the measuring device is positioned on the arm, near the armpit, the area opposite the brachial artery is less vascularized and more fatty. As a result, it is less reactive to internal temperature variations in the body. Thus, the temperature measured by the proximal temperature sensor provides a certain measure of the thermal environment in the immediate vicinity of the body as a whole.

[0058] In other words, in the unworn configuration, the distance between a skin temperature sensor - for example the center of the skin temperature sensors - and the at least one proximal temperature sensor - for example the center of the proximal temperature sensors - is substantially equal to half the circumference of the wearer's arm, preferably greater than 10 cm and / or less than 20 cm, for example between 10 and 20 cm.

[0059] An angular value can be translated into a peripheral measurement for a given arm and vice versa. For example, if we consider that 28 cm is the average perimeter of an adult's arm at the base of the armpit, we can advantageously choose that the center of the skin temperature sensors is 14 cm from the center of the proximal temperature sensors. Under these conditions, the centers of these two groups of sensors are thus placed exactly opposite for a wearer with an arm of 28 cm in perimeter, which is a favorable situation. If we equip this same measuring device with a wearer with an arm of a different size, for example an arm with a perimeter of 20 cm, the point exactly opposite his brachial artery is located at 10 cm.Assuming that the measuring device is installed with the center of the skin temperature sensor group above the artery, the position of the center of the proximal temperature sensor group according to the previous configuration is then 4 cm from the theoretical target point, creating an acceptable offset forward or backward, depending on the direction of installation of the measuring device. These values ​​can also be expressed angularly: the center of the skin temperature sensors forms an angle of 14 cm / 20 cm x 360° = 252° with the center of the proximal temperature sensors, and the offset forward or backward is 4 cm / 20 cm x 360°, or 72°.

[0060] The measuring device may comprise a plurality of proximal temperature sensors, in order to obtain a more accurate estimate of the temperature around the body. According to a characteristic of the invention, the plurality of proximal temperature sensors comprises at least two temperature sensors, preferably aligned along a longitudinal axis of the measuring device. Provision may be made to equip the measuring device with at least three proximal temperature sensors. One function of the proximal temperature sensor(s) is to provide a temperature measurement making it possible to correct the temperature measurements taken at the brachial artery by the skin temperature sensors, this function being able to be satisfactorily provided by a single proximal temperature sensor.

[0061] The accuracy requirement for proximal measurements is less stringent than for skin temperature measurements. Simpler sensors, such as thermocouples or thermistors, can therefore be chosen, as they are simpler to implement and less expensive.

[0062] The measuring device may further comprise at least one complementary physicochemical data sensor. Depending on the type of sensor concerned, it may be arranged on or in the vicinity of the first face of the measuring device (in this case, the at least one physicochemical data sensor is preferably located on the first face while being oriented towards the outside of the device according to the invention and / or is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least one physicochemical data sensor and the wearer's skin), or on or in the vicinity of the second face of the measuring device (in this case, the at least one physicochemical data sensor is preferably located on the second face while being oriented towards the outside of the device according to the invention).

[0063] The addition of functions via physicochemical data sensors enriches the measurements taken by the measuring device according to the invention by contextualizing them, which makes it possible to exclude or include in the inference process temperature measurements which would be due to environmental causes or particular states in which the wearer finds himself.

[0064] According to the invention, the complementary physicochemical data sensor(s) may be a photoplethysmograph configured to measure the wearer's heart rate and oximetry. Advantageously, the photoplethysmograph may be positioned on the first face of the measuring device and is intended to come into contact with the wearer's skin. The photoplethysmograph may be arranged in the immediate vicinity of the central skin temperature sensor. This positioning is advantageous because it increases the measurement quality, due to greater irrigation of the skin in this area.

[0065] To respect the arrangement of the skin temperature sensors organized along at least part of a peripheral line of the measuring device in the worn configuration, the photoplethysmograph can be placed at the center of the group of skin temperature sensors, but sufficiently remote so that the two types of sensors present do not interfere with each other. Therefore, by installing the device on the wearer with the central skin sensor above the brachial artery, the photoplethysmograph will thus be located appropriately, above the artery, and will be able to effectively measure heart rate or oximetry.

[0066] Alternatively or in addition, the complementary physicochemical data sensor may be a galvanometer configured to measure the level of perspiration and sweat secreted by the wearer's body. The galvanometer may comprise at least two sensors measuring low intensities of electric current and making it possible to qualify the body's excretions and to determine the physicochemical composition of said excretions.

[0067] The galvanometer sensors are positioned on the first face of the measuring device, in contact with the wearer's skin. Preferably, the galvanometer sensors are positioned around the center of the proximal temperature sensor group, but located on the opposite face of the device. Sweating in this area reflects general body sweating, which is useful for obtaining general information on the wearer's condition.

[0068] Alternatively or in addition, a galvanometric sensor can be located in the vicinity of the skin temperature sensor group, which allows the specific sweating of the armpit area to be captured.

[0069] Alternatively or in addition, the complementary physicochemical data sensor can be a three-axis accelerometer, a gyroscope or a GPS, configured to obtain information on the kinematic activity of the wearer's body.

[0070] According to a possible embodiment, said first zone in which the skin temperature sensors are arranged is elongated and extends along a longitudinal direction of the measuring device, the skin temperature sensors being arranged aligned or staggered in said elongated zone. This can also apply to cavity temperature sensors.

[0071] A staggered arrangement allows for a higher number of sensors in a smaller area, thus providing more accurate and reliable measurement while limiting the transmission of calories from one sensor to another. Furthermore, with this staggered arrangement, each sensor will collect a measurement that is not significantly different from that of a aligned arrangement.

[0072] The at least one cavity temperature sensor may be arranged opposite said first zone of the skin temperature sensors, preferably in a substantially centered manner, in the longitudinal direction.

[0073] According to one embodiment, the cavity temperature sensor(s) may be opposite said area without necessarily being opposite a skin temperature sensor.

[0074] According to another embodiment, at least one cavity temperature sensor is arranged opposite at least one skin temperature sensor and preferably opposite a central skin temperature sensor, when the number of skin temperature sensors is odd. It will preferably be chosen that this sensor is slightly offset from the line of skin temperature sensors so that the skin temperature sensors are all implanted in a very similar mechanical environment (context of similar materials to have similar insulation and thermal transmission behavior with the exterior and between them) and in order to limit measurement disturbances due to the cavity temperature sensor. Such an arrangement makes it possible to accurately record the skin temperature data in the area of ​​the brachial artery.

[0075] According to one embodiment, two proximal temperature sensors can be provided arranged at each end of the measuring device, in the longitudinal direction, and preferably arranged symmetrically with respect to the central sensor of the group of skin temperature sensors. According to this arrangement, the group of proximal temperature sensors is distributed over two sites which can be widely spaced from one another, in particular when the measuring device is substantially flat in the unworn configuration. However, when the measuring device is in the worn configuration, the proximal temperature sensors are close to one another following the winding of the measuring device.

[0076] According to a possible embodiment, each cavity temperature sensor is positioned opposite a skin temperature sensor. The axis of the skin temperature sensors may or may not be offset from the axis of the cavity temperature sensors.

[0077] Preferably, the cavity temperature sensors are distributed over the entire area of ​​the measuring device in which the skin temperature sensors are arranged.

[0078] According to a characteristic of the invention, the skin temperature sensors and / or the cavity temperature sensors and / or the proximal temperature sensors are distributed over at least one portion of the measuring device, having a dimension in the longitudinal direction of at least 45 mm.

[0079] The configuration of the sensors, for example 7 distributed over 50 mm, can change depending on the diameter of the measuring device. For example, we can provide 5 sensors distributed over 35 mm for a baby's arm or 11 sensors distributed over 80 mm for an adult wearer with a very high BMI.

[0080] According to a characteristic of the invention, the skin temperature sensors and / or the cavity temperature sensors and / or the proximal temperature sensors are aligned on a longitudinal axis of the measuring device.

[0081] According to a characteristic of the invention, the skin temperature sensors and / or the cavity temperature sensors and / or the proximal temperature sensors are spaced regularly with an identical center distance.

[0082] According to a characteristic of the invention, the skin temperature sensors and / or the cavity temperature sensors and / or the proximal temperature sensors are arranged in a staggered or oblique manner on the respective faces of the measuring device.

[0083] According to a possible embodiment, the measuring device is in the form of a strip elongated in a longitudinal direction (X) which, in the worn configuration, corresponds substantially to a peripheral line of the measuring device, the strip having: a length, in the direction (X), preferably greater than 12 cm, even better greater than 15 cm, or even greater than 20 cm; a width, in a direction which is substantially parallel to the axis (Z) of the cylinder in the carried configuration, preferably less than 6 cm, even better less than 4 cm, for example of the order of 3 cm; and the band having a median longitudinal axis, a median transverse axis, an upper edge and a lower edge (when the measuring device is worn, the wearer being in the anatomical reference position, i.e. in particular standing, with the arms alongside the body).

[0084] At least one of the first face and the second face may comprise a planar surface in an unsupported configuration.

[0085] The skin temperature sensors and / or the at least one cavity temperature sensor may be arranged substantially along the median longitudinal axis of the strip.

[0086] Alternatively, the skin temperature sensors and / or the at least one cavity temperature sensor may be offset in the direction of the upper edge relative to the median longitudinal axis of the strip. An advantage of this arrangement is that the cavity temperature sensors may be placed as close as possible to the armpit. This may also be advantageous for the skin temperature sensors. This is because the brachial artery is flush under the skin of the arm near the armpit, while it is located deeper in the arm away from the armpit.

[0087] The measuring device may further include: an elongated sheet carrying the skin temperature sensors and the at least one cavity temperature sensor; a housing containing an electronic card and a battery connected to the elongated sheet, the housing preferably carrying the at least one proximal temperature sensor and / or preferably carrying the at least one complementary physicochemical data sensor, when these sensors are present; the housing and the elongated sheet being enclosed, for example by overmolding, in a flexible material.

[0088] Said flexible material may be an elastomer or a medical-grade silicone, which improves the comfort of the wearer of the measuring device and ensures homogeneous contact without detachment with the wearer's skin. In the present invention, "medical-grade silicones" means materials tested for biocompatibility and suitable for use in medical applications.

[0089] For example, an injection of medical grade 35 ShoreA silicone can be implemented. According to this example, the measuring device can be of a thickness substantially equal to 2.5 mm, the electronics including the sensors being integrated into a Kapton sheet 10 mm wide and 0.20 mm thick.

[0090] The tablecloth forms a support for the sensors and also integrates electronic connection components.

[0091] The measuring device may also include a clean coating, advantageously washable, on its first face and / or its second face. It may further include an adhesive portion intended to be stuck to the wearer's arm.

[0092] According to a possible embodiment, the measuring device comprises: a first set of sensors comprising: * at least three skin temperature sensors which are positioned on or in the vicinity of the first face of the measuring device, in a first area of ​​the first set of sensors, and which extend over a first length; preferably, the at least three skin temperature sensors of the first set are arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors of the first set and the skin of the wearer, and / or the first face of the measuring device is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the first face and the skin of the wearer's arm,and the at least three skin temperature sensors of the first set are located on this first face while being oriented towards the outside of the device according to the invention; * at least one cavity temperature sensor which is arranged on or in the vicinity of the second face of the measuring device, in a second zone of the first set of sensors of the measuring device which is at least partly opposite the first zone of the first set of sensors, or substantially adjacent thereto, in projection in a plane orthogonal to said first and second faces; preferably, the at least one cavity temperature sensor of the first set is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the at least one cavity temperature sensor of the first set and the wearer's armpit,and / or the second face of the measuring device is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the second face and the wearer's armpit, and the at least one cavity temperature sensor of the first set is located on this second face while being oriented towards the outside of the device according to the invention; a second set of sensors comprising: * at least three skin temperature sensors which are positioned on or in the vicinity of the second face of the measuring device, in a first zone of the second set of sensors, and which extend over a second length preferably different from the first length; preferably, the at least three skin temperature sensors of the second set are arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors of the second set and the wearer's skin,and / or the second face of the measuring device is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the second face and the skin of the wearer's arm, and the at least three skin temperature sensors of the second set are located on this second face while being oriented towards the outside of the device according to the invention; * at least one cavity temperature sensor which is arranged on or in the vicinity of the first face of the measuring device, in a second zone of the second set of sensors of the measuring device which is at least partly opposite the first zone of the second set of sensors, or substantially adjacent thereto, in projection in a plane orthogonal to said first and second faces. Preferably,the at least one cavity temperature sensor of the second set is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the at least one cavity temperature sensor of the second set and the wearer's armpit, and / or the first face of the measuring device is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the first face and the wearer's armpit, and the at least one cavity temperature sensor of the second set is located on this first face while being oriented towards the outside of the device according to the invention; ,

[0093] The device is preferably arranged to use or activate only one set of sensors at a time from among the first set of sensors and the second set of sensors.

[0094] Preferably: the number of cavity temperature sensor(s) of the first set is less than the number of skin temperature sensors of the first set, and the number of cavity temperature sensor(s) of the second set is less than the number of skin temperature sensors of the second set.

[0095] The measuring device can thus be placed on the wearer: either in a first position, in which the first face is oriented towards the wearer's arm. In this case, the sensors of the first set are used; or in a second position, in which the second face is oriented towards the wearer's arm. In this case, the sensors of the second set are used.

[0096] Specifically, providing that the skin temperature sensors of the first set extend over a different length than the skin temperature sensors of the second set provides a versatile measuring device. More specifically, the first set may be adapted to arms having a perimeter in a first range of perimeter values, and the second set may be adapted to arms having a perimeter in a second range of perimeter values ​​distinct from the first range. A single device may therefore be provided to be usable on substantially any wearer, regardless of their morphology or build.

[0097] According to a second aspect, the invention relates to an assembly comprising a measuring device as previously described and, in addition, a flexible case, intended to receive the measuring device, the case preferably having a window opposite each of the sensors of the measuring device, the case having, on its face intended to be in contact with the wearer's arm, at least one adhesive portion intended to be stuck to the wearer's arm.

[0098] The adhesive portion comprises, for example, a layer of adhesive covered by at least one peelable strip, before first use.

[0099] Alternatively, the measuring device may comprise a portion of non-adhesive adhesive material, for example polyurethane or low-density silicone, said portion being intended to be positioned on the wearer's arm. This portion has the advantage of being cleanable and its adhesive capacity is less strong than an adhesive, which makes it possible to have no difficulty in removing the measuring device from the arm on which it is positioned. Since the adhesion of this portion of non-adhesive adhesive material is generally less strong than that of an adhesive, this portion stabilizes the measuring device on the arm but must be supplemented by a strip of adhesive applied, for example by a nurse, to reliably connect the two ends of the measuring device.

[0100] According to a third aspect, the invention relates to a system for determining a deep internal temperature of a human being, which comprises: a device for measuring a plurality of temperatures or an assembly as previously described; a processing unit configured and / or programmed to determine the deep internal temperature of the wearer of the measuring device, from the temperature data measured by said measuring device.

[0101] The inferred value can be obtained by an algorithm referring to a lookup table constructed by experience.

[0102] According to one feature of the invention, the measuring device comprises at least one transmitter configured to transmit the measured temperature measurement information to a receiver. The transmitter may be an antenna for transmitting the temperature measurement information.

[0103] The measuring device may comprise a display member for the determined deep internal temperature, the display member being able to be an indicator screen and / or one or more light indicators, for example colored or non-colored light-emitting diodes. The light indicator(s) make it possible, for example, to provide information on one or more operating states of the measuring device.

[0104] The processing unit may comprise at least one memory, which is preferably a cache memory making it possible to collect the temperature data measured at regular or irregular time intervals by the measuring device and to store them.

[0105] The processing unit may comprise a receiver configured and / or programmed to cooperate with a transmitter positioned on the measuring device, for example a transmitting antenna. The receiver may be configured and / or programmed to communicate with the memory of the processing unit in order to store the received temperature data.

[0106] The processing unit may include a display device, configured to display at least the deep internal temperature determined by the processing unit from the measurements made by the measuring device. The display device may be configured to display the raw temperature data and their measurement intervals. The display device of the system may be different and distinct from the display member of the measuring device.

[0107] Communications can be made wired or wireless, for example via Bluetooth.

[0108] The processing unit is preferably arranged and / or programmed to implement step d) and / or e) and / or g) and / or h) and / or i) described below.

[0109] The invention also relates to a method for determining a deep internal temperature of a human being, said method being implemented by means of a determination system according to the invention, the method comprising the following steps: a) measurement of at least one skin temperature at a time t or over a period of time p, by at least three skin temperature sensors of the determination system according to the invention, b) measurement of at least one cavity temperature at a time t or over a period of time p, by at least one cavity temperature sensor of the measuring device of the measuring and determining system according to the invention, c) the measuring device sends the temperature data measured in steps a), b), via a transmitter, to a receiver equipping a processing unit of the measuring and determining system according to the invention, d) the receiver of the processing unit receives the measured temperature data and transmits them to a memory of the processing unit which stores the temperature data,the processing unit compares the skin temperature data for each sensor and determines the skin temperature of the wearer for each sensor for a time t or a period p using for example the average of the temperatures measured for this sensor, the processing unit compares for the or each cavity temperature sensor and determines the cavity temperature for the or each sensor for a time t or a period p using for example the average of the temperatures measured for each sensor, e) from the temperature data retained for each skin temperature sensor and for the or each cavity temperature sensor, for a time t or over at least one period p, the processing unit determines the deep internal temperature of the wearer for example using a lookup table and / or by applying a determination model based on a forest of decision trees and / or on a neural network,using the temperature data for each sensor for a time t or a period p, or a data set corresponding to the temperature data for each sensor recorded during a sliding observation period P.,

[0110] The method may comprise a step f) carried out in parallel with steps a) and / or b) and / or following steps a) and b) and consisting of the measurement of at least one proximal temperature at a time t or over a period of time p. In this case, step d) will preferably be completed by the processing of the proximal temperature measurements, with the aim of obtaining a single value for the or each proximal temperature sensor. Thus, for the or each proximal temperature sensor, the processing unit compares the values ​​and determines the proximal temperature for this sensor for a time t or a period p using for example the average of the temperatures measured for each sensor. Processing e) will then integrate this or these data in addition to the other temperature values ​​for the purpose of determining the deep internal temperature.

[0111] According to a characteristic of the invention, the deep internal temperature can be determined by the processing unit as a function of complementary parameters originating from one or more complementary physicochemical data sensors.

[0112] Preferably, the determination of the deep internal temperature can be carried out from the measurements taken in steps a), b), f) and from data characterizing physiological arousal, said data being measured by a photoplethysmograph and / or a galvanometer.

[0113] Even more preferably, the determination of the deep internal temperature can be carried out from the measurements taken in steps a), b), f) and from data characterizing physiological arousal, and from positioning data measured by a three-axis accelerometer for example.

[0114] Preferably, the determination of the deep internal temperature can be carried out from the measurements taken during a preferentially sliding period P during which a succession of steps a), steps b), steps f) is carried out and during which a set of data characterizing a physiological awakening over this same period P is collected.

[0115] According to a characteristic of the invention, after the deep internal temperature of the wearer has been determined for a time t or over at least one period p, the processing unit can order the display device to display the determined deep internal temperature, during a step g).

[0116] The processing unit, from the determined deep internal temperature, can be configured and / or programmed to determine a state of the wearer, during a step h), for example by correlating the measured deep internal temperature to a state from a database or an abacus integrated in the memory of the processing unit. By state of the wearer is meant for example healthy state, feverish state, critical state.

[0117] According to a characteristic of the invention, the state of the wearer can be communicated by the processing unit to the display device which displays the state of the wearer, during a step i).

[0118] The method according to the invention may further comprise the following steps: After step a), a step a') of determining a single skin temperature value, preferably by choosing the highest value among the skin temperatures of or measured by the at least three skin sensors, After step b), a step b') of determining a single cavity temperature value, preferably by choosing the highest value among the cavity temperatures of or measured by the at least one cavity temperature sensor. from the single skin temperature value determined in step a', from the single cavity temperature value determined in step b', the processing unit determines the deep internal temperature of the human being wearer.

[0119] The method according to the invention may further comprise the following steps: a step FFF of measuring at least one proximal temperature at a time t or over a period of time p, by the at least one proximal temperature sensor, a step FFF' of determining a single proximal temperature value, preferably by choosing the highest value among the proximal temperatures of or measured by the at least one proximal temperature sensor from the single skin temperature value determined in step a', the single cavity temperature value determined in step b', the single proximal temperature value determined in step FFF', the processing unit determines the deep internal temperature of the human being wearer. Brève description des figures

[0120] The invention will be better understood from the following description, which relates to embodiments according to the present invention, given as non-limiting examples and explained with reference to the attached schematic figures. The attached schematic figures are listed below: [ Fig. 1 ] is a plan view of the measuring device according to one embodiment of the invention, in the unsupported configuration, from the side of its second face; [ Fig. 2 ] is a plan view of the measuring device of the figure 1 , in unsupported configuration, on the side of its first face; [ Fig. 3 ] is a view similar to the figure 1 , showing transparently the internal components of the measuring device; [ Fig. 4 ] is a partial side view of the measuring device figure 1 , in unported configuration; [ Fig. 5 ] is an exploded perspective view of part of the measuring device of the figure 1 , showing an elongated tablecloth and a case; [ Fig. 6 ] is a perspective view of the water table of the figure 5 ; [ Fig. 7a ] is a perspective view of a case for receiving a measuring device according to one embodiment of the invention, showing one face of the case; [ Fig. 7b ] is a view similar to the figure 7a , showing an opposite face of the case; [ Fig. 8 ] is a sectional view of the measuring device of the figure 1 in carried configuration; [ Fig. 9 ] is a schematic representation of a measurement and determination system according to one embodiment of the invention, the device being in a worn configuration; [ Fig. 10 ] is a partial perspective view of an alternative embodiment of a device according to the invention, in the unworn configuration; [ Fig. 11 ] is a partial perspective view of another alternative embodiment of a device according to the invention, in the uncarried configuration; [ Fig. 12 ] is a partial perspective view of yet another alternative embodiment of a device according to the invention, in the uncarried configuration; [ Fig. 13a ] is a schematic view of the first face of a measuring device according to another embodiment, in non-carried configuration; [ Fig. 13b ] is a schematic view of the second face of the measuring device of the figure 13a , in unported configuration; [ Fig. 13c ] illustrates the measuring device of the figure 13a in the carried configuration, in a first position; [ Fig. 13d ] illustrates the measuring device of the figure 13a in the carried configuration, in a second position.

[0121] These embodiments being in no way limiting, it will be possible in particular to consider variants of the invention comprising only a selection of characteristics described or illustrated subsequently isolated from the other characteristics described or illustrated (even if this selection is isolated within a sentence comprising these other characteristics), if this selection of characteristics is sufficient to confer a technical advantage or to differentiate the invention compared to the state of the prior art. This selection comprises at least one preferably functional characteristic without structural details, and / or with only a part of the structural details if this part only is sufficient to confer a technical advantage or to differentiate the invention compared to the state of the prior art. Description détaillée

[0122] THE figures 1 à 6 represent, some partially, a device 3 for measuring a plurality of temperatures according to an embodiment of the invention.

[0123] On the figures 1 à 4 , the measuring device 3 is shown in its unworn configuration in which, in the non-limiting example illustrated, the measuring device 3 is substantially flat; on the figures 8 et 9 , the measuring device 3 is shown in its worn configuration in which it is at least partially wound on itself and forms at least a portion of a cylinder with axis (Z).

[0124] In the carried configuration, as illustrated in the figure 9 , the measuring device 3 surrounds at least partially, transversely, an arm 100 of a wearer 102, close to a corresponding armpit 101 of the wearer's body, so that the axis (Z) of the measuring device 3 is substantially coincident with the axis of said arm 100.

[0125] In the embodiment shown, the measuring device 3 is an armband surrounding the arm of a human being, totally or partially depending on the circumference of the arm 100 and the size of the measuring device 3.

[0126] The measuring device 3 comprises a first face 31 (visible on the figure 2 ) and a second face 32 (visible on the figure 1 ) opposite the first face 31.

[0127] In the carried configuration, the first face 31 of the measuring device 3 is turned towards the axis (Z) as seen in the figure 8 , the first face 31 then being in contact with the skin of the wearer's arm 100.

[0128] As illustrated on the figures 1 à 4 , the measuring device 3 may be in the form of an elongated strip in a longitudinal direction (X) which, in the worn configuration, corresponds substantially to a peripheral line of the measuring device 3 and to a peripheral line around the arm 100. In the embodiment where the measuring device 3 is substantially planar in the unworn configuration, the faces 31, 32 are situated substantially in planes parallel to (X, Z) in the unworn configuration.

[0129] The (Y) axis is defined as being orthogonal to the (X) and (Z) axes.

[0130] The three axes (X) (Y) and (Z) are orthogonal to each other.

[0131] The strip has a median longitudinal axis 10, a median transverse axis 11, an upper edge 12 and a lower edge 13 (with reference to the worn position of the measuring device 3, the wearer being in the anatomical reference position). It is specified that the terms “upper edge” and “lower edge” are used for the purpose of simplifying the description, and used here with reference to the figures, in particular to the figure 9 in which the measuring device 3 is worn on the wearer's right arm. However, the same measuring device 3 could be placed on the wearer's left arm, with an inverted arrangement, the upper edge then being below the lower edge.

[0132] According to the invention, one may wish to install the measuring device on the wearer's left arm. The device can advantageously be turned over along the anteroposterior axis of the body, so that the upper edge is then below the lower edge. The advantage of this option is that the manipulation of placing the device on the left arm is exactly symmetrical to the manipulation of placing it on the right arm with respect to the sagittal plane of the body, which is a real ergonomic and cognitive advantage for caregivers, in addition all the sensors are positioned on the locations of the body symmetrical to the previous locations, with respect to the sagittal plane of the body.

[0133] Alternatively, the device can be passed from the right arm to the left arm without turning it over, but taking care of course to turn it on itself around the Z axis, in order to position the cutaneous sensors centered opposite the brachial artery of the left arm. This alternative is less interesting than the previous alternative for the consistency of the results since the sensors are potentially not positioned on symmetrical areas of the body according to the sagittal plane.

[0134] The strip has a length L in the direction (X), preferably greater than 12 cm, even better greater than 15 cm, or even greater than 20 cm, and a width I, in a direction which is substantially parallel to the axis (Z) of the cylinder in the carried configuration, of approximately 3 cm.

[0135] As seen on the figures 3 , 5 et 6 , the measuring device 3 comprises a sheet 15 elongated in the direction (X), and a housing 20 which can be formed from a base 21 and a cover 22 which can be assembled to the base 21. The housing 20 contains an electronic card 23 and a battery 24 connected to the elongated sheet 15. The sheet 15 has a thickness e, in the direction (Y), as illustrated in the figure 4 .

[0136] According to the invention, the measuring device 3 comprises a plurality of skin temperature sensors 33, more precisely at least three skin temperature sensors 33, which are configured to measure a skin temperature of the wearer 102. The skin temperature sensors 33 are positioned on or in the vicinity of the first face 31 of the measuring device 3, and extend over at least a portion of a peripheral line of the measuring device 3 in the worn configuration.

[0137] The at least three skin temperature sensors are arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors and the wearer's skin.

[0138] The first face of the measuring device is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the first face and the skin of the wearer's arm, and the at least three skin temperature sensors are located on this first face while being oriented towards the outside of the device 3.

[0139] In the example illustrated on the figure 2 , the measuring device 3 comprises seven skin temperature sensors 33. Of course, the invention is not limited to this example or to a particular number of sensors. Nevertheless, the more sensors there are, the more precise the skin temperature measurement will be.

[0140] Furthermore, the measuring device 3 comprises at least one cavity temperature sensor 34 which is configured to measure a temperature in or near the armpit 101 of the wearer 102. The cavity temperature sensor 34, which here is unique, without this being limiting, is arranged on or near the second face 32 of the measuring device 3. The cavity temperature sensor 34 is oriented outwards, towards the armpit 101, and is therefore impacted in certain positions of the wearer by the temperature conditions of the armpit 101. Providing several cavity temperature sensors 34 makes it possible to obtain a more precise measurement of the cavity temperature.

[0141] The at least one cavity temperature sensor is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the at least one cavity temperature sensor and the wearer's armpit.

[0142] The second face of the measuring device is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the second face and the wearer's armpit, and the at least one cavity temperature sensor is located on this second face while being oriented towards the outside of the device 3.

[0143] The number of cavity temperature sensor(s) (34) is less than the number of skin temperature sensors (33).

[0144] Concretely, the elongated sheet 15 forms a support for the skin temperature sensors 33 and the cavity temperature sensor 34, and also integrates electronic connection members between these sensors and the electronic card 23.

[0145] On the figure 6 we see the cavity temperature sensor 34 on the same plane as the skin temperature sensors 33 but on an offset tab. This configuration makes it possible to turn the tab 180° and thus to locate the cavity temperature sensor 34 on the second face 32 of the measuring device 3, therefore opposite the skin temperature sensors 33.

[0146] The measuring device 3 may also comprise at least one proximal temperature sensor 35 configured to measure a surrounding temperature in the immediate vicinity of the arm 100 of the wearer 102. The proximal temperature sensor 35 is arranged on or in the vicinity of the second face 32 of the measuring device 3. Providing several proximal temperature sensors 35 makes it possible to obtain a more precise measurement of the surrounding temperature.

[0147] The at least one proximal temperature sensor is located on the second face facing outwards from the device 3.

[0148] The at least one proximal temperature sensor is arranged to be in direct contact with the air surrounding the device 3 without an intermediate layer between the at least one proximal temperature sensor and this air.

[0149] In the unworn configuration, a distance between one of the skin temperature sensors (33) (or a point located on one of the skin temperature sensors (33) or the center of the skin temperature sensors) and the at least one proximal temperature sensor (35) (or a point located on one of the proximal temperature sensors (35) or the center of the proximal temperature sensors) is greater than 10 cm (and / or less than 20 cm).

[0150] The measuring device 3 may also comprise at least one complementary physicochemical data sensor 36, such as a photoplethysmograph, configured to measure the heart rate and the oximetry of the wearer, which may be arranged on or in the vicinity of the first face 31 of the measuring device 3 (in this case, the at least one physicochemical data sensor is located on the first face while being oriented towards the outside of the device 3 and / or is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least one physicochemical data sensor and the skin of the wearer), or on or in the vicinity of the second face 32 of the measuring device 3 (in this case,the at least one physicochemical data sensor located on the second face being oriented towards the outside of the device 3 and / or is arranged to be in direct contact with the air surrounding the device 3 without an intermediate layer (the at least one physicochemical data sensor and this air).

[0151] In practice, the proximal temperature sensor 35 and the complementary physicochemical data sensor 36 can be placed at the level of the housing 20, respectively on the cover 22 and on the base 21.

[0152] Furthermore, optionally, the measuring device 3 comprises the sensors of a galvanometer 37 (comprising two sensors) configured to measure the level of perspiration and sweat secreted by the wearer's body.

[0153] The housing 20 and the elongated sheet 15 are enclosed, for example by overmolding, in an envelope 25 made of a flexible material such as silicone.

[0154] Thus, the measuring device 3 is flexible and configured to be able to be deformed from its unworn configuration, for example flat, to its worn, cylindrical configuration. This deformation is typically done by rolling, by curving the median longitudinal axis 10 to make it change from a straight shape to a substantially circular shape (or alternatively: a portion of a circle, a helix or a spiral). The measuring device 3 can thus adapt to the morphology of the wearer and match the shape of the arm 100.

[0155] The skin temperature sensors 33 are arranged in a first zone Z33 of the measuring device 3. According to one embodiment, the first zone Z33 is elongated and extends along the longitudinal direction (X) of the measuring device 3. In the embodiment of the figure 1 , the skin temperature sensors 33 are arranged in an aligned manner. According to a variant not illustrated, the skin temperature sensors 33 could be arranged in a staggered manner in said first zone Z33.

[0156] For example, the length L33 of the first zone Z33 can be of the order of 5 cm.

[0157] The cavity temperature sensor(s) 34 are arranged in a second zone Z34 of the measuring device 3.

[0158] The first zone Z33 of the skin temperature sensors 33 and the second zone Z34 of the cavity temperature sensor(s) 34 can be arranged completely opposite each other, in projection in a plane (X,Z), as is the case on the figure 1 . As seen on the figure 1 , the cavity temperature sensor 34 can be arranged substantially centered opposite this first zone Z33, in the longitudinal direction X.

[0159] According to another variant, the first zone Z33 of the skin temperature sensors 33 and the second zone Z34 of the cavity temperature sensor(s) 34 can be arranged only partially opposite each other, in projection in a plane (X,Z), with a certain overlap.

[0160] According to yet another variant, the first zone Z33 of the skin temperature sensors 33 and the second zone Z34 of the cavity temperature sensor(s) 34 may be separate. They may preferably be substantially adjacent in projection in a plane (X,Z), as is the case in the figure 12 .

[0161] The proximal temperature sensor 35 is preferably positioned substantially diametrically opposite the cavity temperature sensor 34, in the worn configuration of the measuring device 3, as seen in the figure 8 .

[0162] The invention also provides a case 27, illustrated in the figures 7a And 7b , to receive the measuring device 3. This case 27, which is made of a flexible material, makes it possible to protect the measuring device 3, to respond to hygiene considerations (the case can be disposable or washable), and to facilitate the placement of the measuring device 3 on the wearer 102.

[0163] The case 27 preferably has a window 28 facing each of the sensors 33, 34, 35, 36, 37 of the measuring device 3 that it receives, or a single window facing the group of sensors. In addition, the case may have, on its face 29 intended to be in contact with the arm 100 of the wearer 102, at least one adhesive portion 30 intended to be stuck to the arm 100 of the wearer 102. For example, the adhesive portion 30 comprises a layer of adhesive covered by at least one peelable strip, before the measuring device is put in place.

[0164] There figure 9 illustrates a system 1 for determining a deep internal temperature of a human being. The system 1 comprises the measuring device 3, as well as a processing unit 2 configured and / or programmed to determine the deep internal temperature of the wearer 102 of the measuring device 3, from the temperature data measured by said measuring device 3.

[0165] The processing unit 2 comprises, for example, an analog and / or digital electronic circuit, and / or a central unit of a computer, and / or a microprocessor, and / or software means.

[0166] The processing unit 2 and the measuring device 3 are configured and / or programmed to communicate with each other and in particular, the measuring device 3 is configured to transmit the measured temperature data to the processing unit 2 which receives them and analyses them to determine from these data the deep internal temperature of the wearer of the measuring device 3.

[0167] To communicate with the processing unit 2, the measuring device 3 comprises for example a transmitter 38 configured to transmit the measured temperature measurement information to a receiver 41 of the processing unit 2, as shown in figure 9 The transmitter 38 may be an antenna for transmitting temperature measurement information.

[0168] Furthermore, the measuring device 3 may comprise a display member 39 for displaying the determined deep internal temperature, the display member 39 being able to be an indicator screen and / or one or more light indicators, for example colored or non-colored light-emitting diodes. The deep internal temperature determined by the processing unit 2 is communicated to the measuring device 3 and particularly to the display member 39 by the transmitter 38, which is a transmitter / receiver.

[0169] Specifically, the transmitter 38 and the display member 39 can be arranged on or in the housing 20 of the measuring device 3.

[0170] According to one embodiment, the processing unit 2 comprises at least one memory 22, said memory 22 preferably being a cache memory making it possible to collect the temperature data measured at regular or irregular time intervals by the measuring device and to store them. Furthermore, the processing unit 2 may comprise a receiver 41 configured to cooperate with a transmitter 38 positioned on the measuring device 3, for example a transmission antenna. The receiver 41 is preferably also a transmitter and configured to communicate with the memory 22 of the processing unit 2 in order to store the received temperature data.

[0171] The system 1 according to the invention may further comprise a display device 4 configured to display at least the deep internal temperature determined by the processing unit 2 from the measurements taken by the measuring device 3.

[0172] In a highly integrated version of the electronics, it can be provided that the processing unit 2 is integrated into the measuring device 3.

[0173] Different sensor arrangements are illustrated on the figures 10 à 12 .

[0174] A first arrangement is shown on the figure 10 .

[0175] According to this arrangement, the skin temperature sensors 33 are aligned on an axis 10a corresponding to the projection of the median longitudinal axis 10 of the measuring device 3, along the axis (Y), on the first face 31.

[0176] In addition, several cavity temperature sensors 34 (for example three) may be provided which are opposite the zone Z33 in which the skin temperature sensors 33 are located. The cavity temperature sensors 34, shown in dotted lines, may be aligned on an axis 10b corresponding to the projection of the median longitudinal axis 10 of the measuring device 3, along the axis (Y), on the second face 32.

[0177] Seen in projection along the (Y) axis, in a projection plane parallel to (X,Z), the zones Z33 and Z34 are thus at least partially opposite each other, that is to say at least partially superimposed. The superposition may not be total. For example, as seen in the figure 10 , the Z34 zone extends beyond the Z33 zone along the (X) axis, on either side of the Z33 zone. A reverse arrangement - that is, in which the Z33 zone would extend beyond the Z34 zone along the (X) axis - is also conceivable.

[0178] For example, seen in said projection plane, and along the axis (X), there may be a first cavity temperature sensor 34 positioned centrally relative to the first zone Z33, and two cavity temperature sensors 34 positioned on either side and in the immediate vicinity of the ends of the first zone Z33.

[0179] Furthermore, the proximal temperature sensors 35 - for example two in number - can be aligned on the aforementioned axis 10b. The proximal temperature sensors are for example arranged at one end part of the measuring device 3, along the axis (X), while the zones Z33 and Z34 are arranged at the other end part of the measuring device 3, along the axis (X). Of course, the invention is not limited to this arrangement.

[0180] In this “worn configuration” of the measuring device (placed on the user’s arm), comprising proximal temperature sensors located in two subgroups at the two ends of the measuring device, the two subgroups move closer together or come together or overlap, forming a single group.

[0181] Another arrangement is illustrated on the figure 11 .

[0182] According to this arrangement, the group formed by the zones Z33, Z34, and the sensors 33, 34 is identical to what is described above with reference to the figure 10 . On the other hand, in the realization of the figure 11 , this group is located substantially centered on the measuring device 3, along the axis (X).

[0183] A proximal temperature sensor 35 is provided at each end of the measuring device 3. The two proximal temperature sensors 35 are also located on the aforementioned axis 10b. Their location at both ends of the measuring device 3 in the unworn configuration means that in the worn configuration, the two proximal temperature sensors 35 are both positioned substantially diametrically opposite the center of the zone Z33, provided that the measuring device 3 is placed on an arm whose diameter is part of the range for which the measuring device 3 has been designed and sized.

[0184] A third arrangement is illustrated on the figure 12 .

[0185] In this arrangement, the skin temperature sensors 33 are arranged as in the figure 10 Also provided on the first face 31, and substantially on the axis 10a, are a complementary physicochemical data sensor 36 and at least the two sensors 37 of at least one galvanometer, arranged on either side of the complementary physicochemical data sensor 36. The group of sensors 36, 37 may be arranged in the vicinity of the end of the measuring device 3 opposite the end where the zone Z33 is located, along the axis (X).

[0186] One or more cavity temperature sensors 34, here two in number, are also provided. In the production of the figure 12 , the cavity temperature sensors 34 are aligned on an axis 10c which is located on the second face 32, and which is parallel to the axis 10b while being offset from it along the axis (Z). The axis 10c can be offset from the axis 10b in the direction of the lower edge 13.

[0187] When viewed in projection along the (Y) axis, in a projection plane parallel to (X,Z), the zones Z33 and Z34 are thus offset from each other along the (Z) direction. Depending on the dimensions of the sensors 33, 34 and the offset between the axes 10b and 10c, there may be some overlap between the zones Z33 and Z34 along the (Z) axis, or the zones Z33 and Z34 may be adjacent along the (Z) axis, or the zones Z33 and Z34 may be spaced apart from each other along the (Z) axis. Furthermore, in the embodiment shown in the figure 12 , the second zone Z34 is also offset relative to the first zone Z33 along the axis (X). For example, seen in said projection plane, and considering only the relative positioning in projection on the axis (X), we can have a first cavity temperature sensor 34 positioned at the level of the first zone Z33, not necessarily in a centered manner unlike the arrangement of the figure 10 , and a second cavity temperature sensor 34 positioned at a distance from the zone Z33, in the direction of the sensors 36, 37. This arrangement is not limiting.

[0188] The measuring device 3 may also comprise one or more proximal temperature sensors 35. In the embodiment shown, a single proximal temperature sensor 35 is provided, arranged on the axis 10c, at the extreme part of the measuring device 3 opposite the zone Z33, along the axis (X).

[0189] We now refer to the figures 13a à 13d which illustrate another embodiment of the invention. According to this embodiment, it is planned to combine on the same measuring device two complete sets of sensors for two different positions on the wearer's arm. The choice of position is established at the time when the measuring device is installed on the wearer's arm, depending on whether one side or the other is placed in contact with the skin.

[0190] As schematically illustrated on the figures 13a et 13b , the measuring device 3 comprises a first set of sensors S1 and a second set of sensors S2.

[0191] The first set of S1 sensors includes: at least three skin temperature sensors 33-1 which are positioned on or in the vicinity of the first face 31 of the measuring device in a first zone Z33-1, and which extend over a first length L33-1; the at least three skin temperature sensors of the first set are arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors of the first set and the skin of the wearer, and / or the first face of the measuring device is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the first face and the skin of the wearer's arm, and the at least three skin temperature sensors of the first set are located on this first face while being oriented towards the outside of the device 3; at least one cavity temperature sensor 34-1 which is arranged on or in the vicinity of the second face 32 of the measuring device 3 in a second zone Z34-1;the at least one cavity temperature sensor of the first set is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the at least one cavity temperature sensor of the first set and the wearer's armpit, and / or the second face of the measuring device is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the second face and the wearer's armpit, and the at least one cavity temperature sensor of the first set is located on this second face while being oriented towards the outside of the device 3; and, preferably, a proximal temperature sensor 35-1 which is arranged on or in the vicinity of the second face 32 of the measuring device 3. ;

[0192] Furthermore, as already described, the zones Z33-1 and Z34-1 are at least partly opposite each other or are substantially adjacent, in projection in a plane orthogonal to the first and second faces 31, 32.

[0193] The second set of S2 sensors includes: at least three skin temperature sensors 33-2 which are positioned on or in the vicinity of the second face 32 of the measuring device 3, in a first zone Z33-2, and which extend over a second length L33-2 advantageously different from the first length L33-1. In the embodiment shown, L33-2 is less than L33-1. In addition, there may be a different spacing between adjacent skin temperature sensors depending on whether these sensors belong to the first set S1 or to the second set S2;the at least three skin temperature sensors of the second set are arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors of the second set and the skin of the wearer, and / or the second face of the measuring device is arranged to be in direct contact with the skin of the wearer's arm without an intermediate layer between the second face and the skin of the wearer's arm, and the at least three skin temperature sensors of the second set are located on this second face while being oriented towards the outside of the device 3; at least one cavity temperature sensor 34-2 which is arranged on or in the vicinity of the first face 31 of the measuring device 3, in a second zone Z34-2;the at least one cavity temperature sensor of the second set is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the at least one cavity temperature sensor of the second set and the wearer's armpit, and / or the first face of the measuring device is arranged to be in direct contact with the wearer's armpit without an intermediate layer between the first face and the wearer's armpit, and the at least one cavity temperature sensor of the second set is located on this first face while being oriented towards the outside of the device 3; and, preferably, a proximal temperature sensor 35-2 which is arranged on or in the vicinity of the first face 31 of the measuring device 3. ;

[0194] The device is arranged to use or activate only one set of sensors at a time from among the first set of sensors and the second set of sensors: only one set of sensors at a time from among the first set of sensors and the second set of sensors is activated to measure at least one temperature, while the other set of sensors from among the first set of sensors and the second set of sensors is inactive and is not used to measure one or more temperatures.

[0195] The device 3 and / or the system 1 (more precisely the electronic and / or software means 23 and / or the processing unit 2) is arranged and / or programmed to determine which face 31 or 32 respectively is oriented towards the user's arm and which face 32 or 31 respectively is oriented towards the user's armpit, and: if face 31 is facing the user's arm and face 32 is facing the user's armpit, activating the first set of sensors and deactivating the second set of sensors, and if face 32 is facing the user's arm and face 31 is facing the user's armpit, activating the second set of sensors and deactivating the first set of sensors.

[0196] The device 3 and / or the system 1 (more precisely the electronic and / or software means 23 and / or the processing unit 2) is arranged and / or programmed to assign the face facing the user's armpit as being the face, among the faces 31 and 32: having measured temperature variations (by sensors 33-1, 33-2, 34-1 and / or 34-2) of greater amplitudes and / or higher temporal frequency (because in its normal use, the arm regularly separates from the armpit while the device 3 remains attached to the arm), and / or having the highest measured temperature (by sensors 33-1, 33-2, 34-1 and / or 34-2).

[0197] Thus, in the method according to the invention implemented in the device 3 and / or system 1 (more precisely by the electronic and / or software means 23 and / or the processing unit 2), there is a determination of which face respectively 31 or 32 is oriented towards the user's arm and which face respectively 32 or 31 is oriented towards the user's armpit, and: if face 31 is oriented towards the user's arm and face 32 is oriented towards the user's armpit, an activation of the first set of sensors and a deactivation of the second set of sensors, and if face 32 is oriented towards the user's arm and face 31 is oriented towards the user's armpit, an activation of the second set of sensors and a deactivation of the first set of sensors. with preferably an assignment of the face oriented towards the user's armpit as being the face, among the faces 31 and 32: having measured temperature variations (by the sensors 33-1, 33-2, 34-1 and / or 34-2) of greater amplitudes and / or higher temporal frequency (because in its normal use, the arm regularly separates from the armpit while the device 3 remains attached to the arm), and / or having a highest measured temperature (by the sensors 33-1, 33-2, 34-1 and / or 34-2).

[0198] As shown in the figures, the number of cavity temperature sensor(s) (34-1) of the first set is less than the number of skin temperature sensors (33-1) of the first set, and As shown in the figures, the number of cavity temperature sensor(s) (34-2) of the second set is less than the number of skin temperature sensors (33-2) of the second set.

[0199] Furthermore, as already described, the zones Z33-2 and Z34-2 are at least partly opposite each other or are substantially adjacent, in projection in a plane orthogonal to the first and second faces 31, 32.

[0200] It should be noted that, on the figure 13a , zones Z34-2 and Z33-1 are offset from each other in the Z direction for reasons of clarity of the drawing. However, this arrangement should not be considered as limiting, since zones Z34-2 and Z33-1 may be arranged in an at least partially superimposed manner. The same remark concerns the figure 13b . In addition, the number of sensors in a given area, their relative spacing and the relative arrangement of the different sensor areas are illustrated by way of non-limiting example.

[0201] Advantageously, the axis of zone Z33-1 and the axis of zone Z34-2 can be superimposed in order to have one or more temperature sensors common to both zones. Similarly, the axis of zone Z33-2 and the axis of zone Z34-1 can be advantageously superimposed in order to have one or more temperature sensors common to both zones. These configurations are equivalent in terms of the precision of the values ​​obtained, but present a real advantage in economic terms since the same information is captured while requiring fewer sensors.

[0202] Furthermore, although sensors 36, 37 are not shown, this does not necessarily mean that they are absent.

[0203] In other words, in the measuring device 3 of the figures 13a à 13d , Two temperature sensor installations have been combined. This allows, with the same measuring device 3, to adapt to a wide range of arm diameters.

[0204] The measuring device 3 illustrated in the unsupported configuration hovers over the figures 13a et 13b can be rolled up to its carried configuration, in two different positions. In a first position, illustrated on the figure 13c , the first face 31 is oriented towards the wearer's arm. In this case, the sensors of the first set S1 are used. In a second position, illustrated in the figure 13d , the second face 32 is oriented towards the wearer's arm. In this case, the sensors of the second set S2 are used.

[0205] Thus, the measuring device 3, in the first position of the figure 13c , can for example be intended for arms with a circumference between 20 cm and 28 cm; and the same measuring device 3 can be returned to the second position illustrated in the Figure 13dand advantageously equip an arm whose circumference is 28 cm to 40 cm. The arrangement of the sensors in each of the sets S1, S2 is configured to be adapted to these two morphological ranges.

[0206] Thus, when a caregiver is facing a patient whose arm has a perimeter included in a first range of perimeter values, he will choose to place the first face 31 on the skin side; when the caregiver is facing a patient whose arm has a perimeter included in a second range of perimeter values, he will choose to place the second face 32 on the skin side. In both positions, the measuring device 3 is fully adapted to the wearer and provides measurements with the required precision.

[0207] Of course, we can optimize the number of sensors and use the temperature sensors installed on one side for the first range of perimeters, to carry out the measurements necessary for the second range of perimeters.

[0208] It is noted that these two sets of sensors S1, S2 coexist on the measuring device 3 and are independent. For example, it is possible to provide a device with one face to be placed at the top of the armpit and one face to be placed a little lower, or a device with one face to be placed specifically under the left armpit and the other specifically under the right armpit, etc.

[0209] Skin temperature measurement must be highly accurate and reliable. Specialized temperature sensors for human health, incorporating a high-resolution analog-to-digital converter, have therefore been favored.

[0210] The accuracy requirement for cavity temperature measurements is lower than for skin temperature measurements. Simpler sensors, such as thermocouples or thermistors, can therefore be chosen, as they are simpler to implement and less expensive.

[0211] For simplicity, sensors 33, 34 and 35 are identical: in the present description, each temperature sensor, in particular reference 33, 34, 35, is a temperature sensor referenced “MAX30205 Human Body Temperature Sensor” manufactured by the company MAXIM.

[0212] An embodiment of a method according to the invention for determining a deep internal temperature of a human being, implemented in a system 1 as previously described comprising any variant of device 3 as previously described, comprises the following steps: a) measurement of at least one skin temperature at a time t or over a period of time p, by the at least three skin temperature sensors 33 of the determination system according to the invention, b) measurement of at least one cavity temperature at a time t or over a period of time p, by the at least one cavity temperature sensor 34 of the measuring device of the measuring and determining system according to the invention, c) the measuring device 3 sends the temperature data measured in steps a), b), via the transmitter 38, to the receiver 41 equipping the processing unit 2 of the measuring and determining system according to the invention, d) the receiver 41 of the processing unit receives the measured temperature data and transmits them to the memory 22 of the processing unit which stores the temperature data,the processing unit 2 compares the skin temperature data for each sensor 33 and determines the skin temperature of the wearer for each sensor 33 for a time t or a period p using for example the average of the temperatures measured for this sensor 33, the processing unit 2 compares for the or each cavity temperature sensor 34 and determines the cavity temperature for the or each sensor 34 for a time t or a period p using for example the average of the temperatures measured for each sensor 34, e) from the temperature data retained for each skin temperature sensor 33 and for the or each cavity temperature sensor 34, for a time t or over at least one period p, the processing unit 2 determines the deep internal temperature of the wearer for example using a lookup table and / or by applying a determination model based on a forest of decision trees and / or on a neural network,using the temperature data for each sensor for a time t or a period p, or a data set corresponding to the temperature data for each sensor recorded during a sliding observation period P.,

[0213] The method may comprise a step f) carried out in parallel with steps a) and / or b) and / or following steps a) and b) and consisting of the measurement of at least one proximal temperature at a time t or over a period of time p. In this case, step d) will be completed by the processing of the proximal temperature measurements, with the aim of obtaining a single value for the or each proximal temperature sensor 35. Thus, for the or each proximal temperature sensor 35, the processing unit 2 compares the values ​​and determines the proximal temperature for this sensor 35 for a time t or a period p using for example the average of the temperatures measured for each sensor 35. The processing e) will then integrate this or these data in addition to the other temperature values ​​for the purpose of determining the deep internal temperature.

[0214] An embodiment of a method according to the invention for determining a deep internal temperature of a human being, implemented in a system 1 as previously described comprising any variant of device 3 as previously described, comprises the following steps: Step a) previously described.

[0215] A step a' of determining a single skin temperature value, in particular by choosing the highest value among the skin temperatures of or measured by the at least 3 skin sensors 33 of the determination system according to the invention, step a' being carried out by the measuring device 3 or the processing unit 2.

[0216] Step b as previously described.

[0217] A step b' of determining a single cavity temperature value, in particular by choosing the highest value among the cavity temperatures of or measured by the at least one cavity temperature sensor 34 of the measuring device of the measuring and determination system according to the invention, step b' being carried out by the measuring device 3 or the processing unit 2.

[0218] An FFF step, measurement of at least one proximal temperature at a time t or over a period of time p, by the at least one proximal temperature sensor 35 of the measuring device of the measuring and determination system according to the invention.

[0219] A step FFF' of determining a single proximal temperature value, in particular by choosing the highest value among the proximal temperatures of or measured by the at least one proximal temperature sensor 35 of the measuring device of the measuring and determination system according to the invention, the step FFF' being carried out by the measuring device 3 or the processing unit 2.

[0220] From the single skin temperature value determined in step a', from the single cavity temperature value determined in step b', from the single proximal temperature value determined in step FFF', the processing unit 2 determines the deep internal temperature of the wearer for example by using a look-up table and / or by applying a determination model based on a forest of decision trees and / or on a neural network, using the single data of skin temperature, cavity temperature and proximal temperature retained for a time t or a period p, or a data set corresponding to the data of skin temperature, cavity temperature and proximal temperature during a sliding observation period P.

[0221] The deep internal temperature may be determined by the processing unit 2 based on additional parameters from one or more additional physicochemical data sensors as previously described.

[0222] Preferably, the determination of the deep internal temperature can be carried out from the measurements taken in steps a), b), f) and from data characterizing physiological arousal, said data being measured by a photoplethysmograph and / or a galvanometer.

[0223] Even more preferably, the determination of the deep internal temperature can be carried out from the measurements taken in steps a), b), f) and from data characterizing physiological arousal, and from positioning data measured by a three-axis accelerometer for example.

[0224] Preferably, the determination of the deep internal temperature can be carried out from the measurements taken during a preferentially sliding period P during which a succession of steps a), steps b), steps f) is carried out and during which a set of data characterizing a physiological awakening over this same period P is collected.

[0225] According to a characteristic of the invention, after the deep internal temperature of the wearer has been determined for a time t or over at least one period p, the processing unit 2 can order the display device 4 to display the determined deep internal temperature, during a step g).

[0226] The processing unit 2, from the determined deep internal temperature, can be configured and / or programmed to determine a state of the wearer, during a step h), for example by correlating the measured deep internal temperature to a state from a database or an abacus integrated in the memory of the processing unit 2. By state of the wearer is meant for example healthy state, feverish state, critical state.

[0227] According to a characteristic of the invention, the state of the wearer can be communicated by the processing unit 2 to the display device 4 which displays the state of the wearer, during a step i).

[0228] During each measurement step, the device 3 is preferably worn by the user 102 in its worn configuration, at least partially surrounding an arm 100 of the wearer 102: preferably close to a corresponding armpit 101 of the body of the wearer 102, and / or preferably so that the axis Z of the measuring device 3 is substantially coincident with the axis of said arm 100, and / or preferably the first face 31 of the measuring device 3 then being in contact with the skin of the arm 100 of the wearer 102.

[0229] The value of p is preferably the same for sensors 33 and / or 34 and / or 35.

[0230] The P value is different from the p value.

[0231] The P-value is greater than the p-value.

[0232] The value of P is preferably at least three times greater than the value of p, preferably at least five times greater than the value of p, preferably at least ten times greater than the value of p.

[0233] The value of p is preferably greater than or equal to 1 second, preferably greater than or equal to 5 seconds, preferably greater than or equal to 10 seconds.

[0234] The value of P is preferably greater than or equal to 30 seconds, preferably greater than or equal to 1 minute.

[0235] Typically, the chosen acquisition frequency is 1 Hz for all temperature sensors. For each temperature sensor, a value is extracted every 30 seconds, so p = 30". The sliding period P chosen is 5 minutes, in other words, 10 periods p are used, so a history of 10 values ​​for each sensor, for the purpose of inferring the central temperature value.

[0236] A predictive algorithm can be added to the inference algorithm, which aims to predict the temperature value for the next few minutes, to indicate to the caregiver the general trend observed in order to help them anticipate the actions to be taken.

[0237] Of course, the invention is not limited to the embodiments described and shown in the attached figures. Modifications remain possible, particularly from the point of view of the constitution of the various elements, without departing from the scope of protection of the invention, as defined by the claims.

Claims

1. Device for measuring a plurality of temperatures with the aim of determining a core internal temperature of a human being (102) wearing said measurement device, the measurement device (3) having a first face (31) and a second face (32) opposite the first face (31) and being configured to be able to be in a worn configuration in which the measurement device (3) is at least partially wound over itself and forms at least one cylindrical portion having an axis (Z), the first face (31) being turned towards the axis (Z), the measurement device (3), in its worn configuration, being intended to at least partially encircle an arm (100) of the wearer (102), in the vicinity of a corresponding armpit (101) of the body of the wearer (102), so that the axis (Z) of the measurement device (3) is substantially merged with the axis of said arm (100), the first face (31) of the measurement device (3) then being in contact with the skin of the arm (100) of the wearer (102), characterized in that the measurement device (3) comprises: - at least three skin temperature sensors (33) configured to measure a skin temperature of the wearer (102), the skin temperature sensors (33) being positioned on the first face (31) of the measurement device (3), in a first zone (Z33) of the measurement device (3), and extending substantially over at least part of a peripheral line of the measurement device (3) in the worn configuration; - at least one cavity temperature sensor (34) configured to measure a temperature in said armpit (101) of the wearer (102), the cavity temperature sensor (34) being arranged on the second face (32) of the measurement device (3), in a second zone (Z34) of the measurement device (3); said first zone (Z33) of the skin temperature sensors (33) and said second zone (Z34) of the cavity temperature sensor or sensors (34) being arranged at least partly facing each other or being substantially adjacent, projecting in a plane orthogonal to said first and second faces (31, 32) the device (3) being configured to be able to be in an unworn configuration in which it is substantially flat the device also comprising at least one proximal temperature sensor (35) configured to measure a surrounding temperature in the immediate vicinity of the arm (100) of the wearer (102), the proximal temperature sensor (35) being arranged on or near the second face (32) of the device (3), the device also being characterized in that, in the unworn configuration, the distance between a skin temperature sensor (33) and the at least one proximal temperature sensor (35) is greater than 10 cm.

2. Measurement device according to claim 1, characterized in that the number of cavity temperature sensor(s) (34) is less than the number of skin temperature sensors (33).

3. Measurement device according to claim 1 or 2, characterized in that: - the first face of the measurement device is arranged to be in direct contact with the skin of the arm of the wearer without an intermediate layer between the first face and the skin of the arm of the wearer, and the at least three skin temperature sensors are situated on this first face, wherein they are oriented towards the exterior of the device, and - the second face of the measurement device is arranged to be in direct contact with the armpit of the wearer without an intermediate layer between the second face and the armpit of the wearer, and the at least one cavity temperature sensor is situated on this second face, wherein it is oriented towards the exterior of the device.

4. Measurement device according to any one of the preceding claims, characterized in that, in the worn configuration, it extends angularly over at least 90°.

5. Measurement device according to any one of the preceding claims, characterized in that it is flexible and configured to be able to be deformed, by winding, between an unworn configuration and the worn configuration.

6. Measurement device according to any one of the preceding claims, characterized in that the proximal temperature sensor (35) is angularly offset with respect to the at least one cavity temperature sensor (34), in the worn configuration of the measurement device (3), by at least 90°.

7. Measurement device according to any one of the preceding claims, characterized in that it also comprises at least one additional physicochemical data sensor (36).

8. Measurement device according to any one of the preceding claims, characterized in that said first zone (Z33), in which the skin temperature sensors (33) are arranged, is elongated and extends in a longitudinal direction of the measurement device (3), the skin temperature sensors (33) being arranged in an aligned manner or staggered in said first elongated zone (Z33).

9. Measurement device according to claim 8, characterized in that the at least one cavity temperature sensor (34) is arranged facing said first zone (Z33) of the skin temperature sensors (33) in the longitudinal direction.

10. Measurement device according to any one of the preceding claims, characterized in that it is in the form of a band elongated in a longitudinal direction (X) which, in the worn configuration, substantially corresponds to a peripheral line of the measurement device (3), the band having: - a length (L), in the direction (X), greater than 12 cm; - a width (I), in a direction which is substantially parallel to the axis (Z) of the cylinder in the worn configuration, of less than 6 cm; and the band having a longitudinal central axis (10), a transverse central axis (11), an upper edge (12) and a lower edge (13).

11. Measurement device according to claim 10, characterized in that the skin temperature sensors (33) and / or the at least one cavity temperature sensor (34) are arranged substantially along the longitudinal central axis (10) of the band.

12. Measurement device according to claim 10, characterized in that the skin temperature sensors (33) and / or the at least one cavity temperature sensor (34) are offset in the direction of the upper edge (12) with respect to the longitudinal central axis (10) of the band.

13. Measurement device according to one of claims 10 to 12, characterized in that it comprises: - an elongated tape (15) bearing the skin temperature sensors (33) and the at least one cavity temperature sensor (34); - a case (20) containing an electronic board (23) and a battery (24) connected to the elongated tape (15), the case bearing the at least one proximal temperature sensor (35) and / or bearing the at least one additional physicochemical data sensor (36), if the measurement device (3) is according to claim 7; the case (20) and the elongated tape (15) are covered, for example by over-moulding, in a flexible material such as a silicone.

14. Measurement device according to any one of the preceding claims, characterized in that it comprises: - a first set of sensors (51) containing: -- at least three skin temperature sensors (33-1), which are positioned on or near the second face (31) of the measurement device (3), in a first zone (Z33-1) of the first set of sensors, and which extend over a first length (L33-1); -- at least one cavity temperature sensor (34-1), which is arranged on or near the second face (32) of the measurement device (3), in a second zone (Z34-1) of the first set of sensors of the measurement device (3) which is at least partly facing the first zone (Z33-1) of the first set of sensors, or substantially adjacent to it, projecting in a plane orthogonal to said first and second faces (31, 32); - a second set of sensors (S2) containing: -- at least three skin temperature sensors (33-2), which are positioned on or near the second face (32) of the measurement device (3), in a first zone (Z33-2) of the second set of sensors, and which extend over a second length (L33-2) different from the first length (L33-1); -- at least one cavity temperature sensor (34-2), which is arranged on or near the first face (31) of the measurement device (3), in a second zone (Z34-2) of the second set of sensors of the measurement device (3) which is at least partly facing the first zone (Z33-2) of the second set of sensors, or substantially adjacent to it, projecting in a plane orthogonal to said first and second faces (31, 32) the device being arranged to use or activate a single set of sensors at once from the first set of sensors and the second set of sensors.

15. Measurement device according to claim 14, characterized in that: - the number of cavity temperature sensor(s) (34-1) of the first set is less than the number of skin temperature sensors (33-1) of the first set, and - the number of cavity temperature sensor(s) (34-2) of the second set is less than the number of skin temperature sensors (33-2) of the second set.

16. Assembly containing a measurement device (3) according to any one of the preceding claims, characterized in that it comprises, moreover, a flexible sheath (27), intended to receive the measurement device (3), the sheath (27) having a window (28) facing each of the sensors of the measurement device (3), the sheath (27) having, on its face (29) intended to be in contact with the arm (100) of the wearer (102), at least one adhesive portion (30) intended to be stuck on the arm (100) of the wearer (102).

17. Assembly according to claim 16, characterized in that the adhesive portion (30) comprises an adhesive layer covered by at least one band that can be peeled off before the first use.

18. System for determining a core internal temperature of a human being, characterized in that it comprises; - a device (3) for measuring a plurality of temperatures according to one of claims 1 to 15, or an assembly according to one of claims 16 or 17; - a processing unit (2) configured and / or programmed to determine the core internal temperature of the wearer (102) of the measurement device (3), based on the temperature data measured by said measurement device (3).

19. Method for determining a core internal temperature of a human being, implemented by means of a system according to claim 18, the method comprising the following steps: a) measuring at least one skin temperature at a time t or over a period of time p, by the at least three skin temperature sensors of the determination system, b) measuring at least one cavity temperature at a time t or over a period of time p, by the at least one cavity temperature sensor of the measurement device of the measurement and determination system, c) the measurement device sends the temperature data measured in steps a), b), through a transmitter, to a receiver equipping the processing unit of the measurement and determination system according to the invention, d) the receiver of the processing unit receives the measured temperature data and transmits them to a memory of the processing unit, which stores the temperature data, - the processing unit compares the skin temperature data for each sensor and determines the skin temperature of the wearer for each sensor for a time t or a period p using for example the average of the temperatures measured for this sensor, - the processing unit compares, for the or each cavity temperature sensor, and determines, for the or each sensor, the cavity temperature for a time t or a period p using for example the average of the temperatures measured for each sensor, e) based on the item of temperature data retained for each skin temperature sensor and for the or each cavity temperature sensor, for a time t or over at least one period p, the processing unit determines the core internal temperature of the wearer, using the temperature data for each sensor for a time t or a period p, or a set of data corresponding to the temperature data for each sensor collected during a rolling observation period P.

20. Method according to claim 19, implemented by means of a system according to claim 18, also comprising the following steps: - after step a), a step a') of determining a single skin temperature value, preferably by selecting the highest value from among the skin temperatures from or measured by the at least three skin sensors (33), - after step b), a step b') of determining a single cavity temperature value, preferably by selecting the highest value from among the cavity temperatures from or measured by the at least one cavity temperature sensor (34), - based on the single skin temperature value determined in step a' and the single cavity temperature value determined in step b', the processing unit (2) determines the core internal temperature of the human wearer.

21. Method according to claim 20, implemented by means of a system according to claim 18, also comprising the following steps: - a step FFF of measuring at least one proximal temperature at a time t or over a period of time p, by the at least one proximal temperature sensor (35), - a step FFF' of determining a single proximal temperature value, preferably by selecting the highest value from among the proximal temperatures from or measured by the at least one proximal temperature sensor (35), - based on the single skin temperature value determined in step a', the single cavity temperature value determined in step b' and the single proximal temperature value determined in step FFF', the processing unit (2) determines the core internal temperature of the human wearer.