PRMT5 INHIBITORS

MA62655B1Active Publication Date: 2026-08-31AMGEN INC

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Patent Information

Application Number: MA62655
Authority / Receiving Office: MA · MA
Patent Type: Patents
Current Assignee / Owner
Priority Date: 2021-12-15
Filing Date: 2021-12-15
Publication Date: 2026-08-31
Estimated Expiration: 2041-12-15

Application Information

Patent Timeline

15 Dec 2021

Priority

15 Dec 2021

Application

MA62655

31 Aug 2026

Publication

MA62655B1

IPC: A61K31/4353; C07D487/14; C07D491/04; C07D491/14

CPC: C07D491/04; C07D491/14; C07D487/14; C07D213/79; A61P35/00; C07D471/06; C07D491/06; C07D491/16

Inventors: WEIRES Nicholas Anthony; LOPEZ Patricia

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Abstract

The invention relates to novel PRMT5 inhibitors of formula I and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. The compounds of the present invention are useful for inhibiting PRMT5 activity and may be used in the treatment of proliferative, metabolic, and blood disorders. The compounds of formula I have the following structure:

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Patent Information

Abstract