Pharmaceutical combination comprising ponesimod and its use in the treatment of multiple sclerosis

Abstract

The present invention relates to a pharmaceutical combination comprising a first active ingredient, which is (R)-5-[3-chloro-4-(2,3-dihydroxypropoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one or a pharmaceutically acceptable salt thereof, and a second active ingredient, which is selected from the group consisting of methyl fumarate, dimethyl fumarate, (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate and 2-(2,5-dioxopyrrolidin-1-yl)ethyl methyl (2E)but-2-ene-1,4-dioate, or a pharmaceutically acceptable salt thereof.