CDCP1-TARGETED THERAPIES

Abstract

The present invention relates to an isolated antibody, or an antigen-binding fragment thereof, that binds specifically to the CUB-containing protein 1 (CDCP1), characterized in that it comprises: (i) a heavy chain variable region (HV) comprising: (a) a complementarity-determining region HV one (CDRH1) comprising the amino acid sequence of SEQ ID NO: 2, (b) a complementarity-determining region HV two (CDRH2) comprising the amino acid sequence of SEQ ID NO: 3, and (c) a complementarity-determining region HV three (CDRH3) comprising the amino acid sequence of SEQ ID NO: 27, and (ii) a light chain variable region (LV) comprising: (a) a complementarity-determining region LV one (CDRL1) comprising the amino acid sequence of SEQ ID NO: 12, (b) a complementarity-determining region LV two (CDRL2) comprising the amino acid sequence of SEQ ID NO: 13,and (c) a complementarity-determining region VL three (CDRL3) comprising the amino acid sequence of SEQ ID NO:31.,