Oral composition in the form of a bioadhesive gel based on isoxazoline

Abstract

The present invention relates to the composition of a long-acting bioadhesive endoparasiticidal gel based on an isoxazoline alone or in combination with other antiparasitics, with a high level of adhesion to the oral mucosa, high palatability which greatly facilitates its dosage and procedures for its preparation. Ectoparasitosis is a parasitic condition caused by fleas, ticks and mites that infest the superficial layers of the skin in small animals. Control of this disease is of great importance and readily achievable through the use of suitable antiparasitic agents such as isoxazolines, which is a chemical compound widely administered orally in tablet form due to the organoleptic and physicochemical characteristics of the compositions known to date. The present invention demonstrates that it is possible to administer isoxazolines in the pharmaceutical form of an oral gel at concentrations of up to 20.0% w / v, overcoming the organoleptic and physicochemical limitations of compositions known to date. These factors, never before included in oral ectoparasiticide compositions based on isoxazolines, offer a significant competitive advantage over existing compositions.