NEW COMPOUND DERIVED FROM PHTHALAZINE AS AN SOS1 INHIBITOR AND ITS USE

Abstract

It refers to phthalazine-derived compounds as an SOS1 inhibitor and their use in inhibiting the binding of SOS1 to RAS and / or RAC1 family proteins, their pharmaceutically acceptable derivatives, or a pharmaceutical composition containing said compound.The compound of Chemical Formula 1, its optical isomers, its diastereomers, its hydrates, its solvates, and a compound selected from its pharmaceutically acceptable salts: wherein, R1 is H or C1-4 alkyl; R2 is H, C1-4 alkyl, C1-4 haloalkyl, among others; R3 is R3a or (A); R3a is independently halogen, hydroxy, cyano, among others; m is an integer from 0 to 5; L2 is a direct linkage, -O-(CH2)p, or -CH=CH-(CH2)q; p is an integer from 0 to 3; q is an integer from 0 to 2; rings A1 and A2 are independently C6-10 aryl, C4-10 heteroaryl, C3-10 carbocyclyl, among others; X1 is -O(R4) or -N(R5)(R6); L1 is a direct bond, -C(O)-, -O-, among others; n is an integer from 0 to 2; ring B is a C3-10 carbocyclyl, C2-9 heterocyclyl, C6-10 aryl, among others.