ANTI-TRKA ANTIBODIES AND THEIR USES

Abstract

The present invention discloses anti-TrkA antibodies, or antigen-binding fragments thereof, and uses of the antibodies or fragments thereof in neuronal dysfunction associated with diabetic peripheral neuropathy, chemotherapy-induced peripheral neuropathy, nerve injury, among others.An anti-tropomyosin receptor kinase A (TrkA) antibody, or an antigen-binding fragment thereof, comprising: a heavy chain complementarity-determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO: 71, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 72, an HCDR3 comprising the amino acid sequence of SEQ ID NO: 73, a light chain complementarity-determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO: 74, an LCDR2 comprising the amino acid sequence of SEQ ID NO: 75, and an LCDR3 comprising the amino acid sequence of SEQ ID NO: 76.