LIPID COMPOUNDS

Abstract

The present invention relates to lipids, including triazole, alkyl, and alkene substituted amine compounds, intermediates in their synthesis, and uses of said compounds in lipid nanoparticle compositions for drug delivery and cancer treatments. It is a compound of formula (G1.1) where the B portion is C(O)O, OC(O), C(O)NH, among others; p = 1-6; p' = 0-4; p" = 0-4; m' = 0, 1; the T portion is CH((CH2)llCH3)-CH2)ll'CH3, ll = 2-6, ll' = 2-6, CH3-(CH2)k-CH2, k = 2-14, NH, among others; A is an amino portion, and said amino portion A is chosen according to the p value as follows, where the term is used to refer to an N-binding site of an LT portion, and ( ) (or ( ) interchangeably) is used to refer to two separate N-binding sites of two LT portions.