FUSED RING COMPOUNDS

Abstract

This refers to fused-ring compounds of Formula (I), used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by administration thereof. The compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein, R1 is an electrophilic portion capable of forming a covalent bond with a cysteine ​​residue at position 12 of a G12C K-Ras mutant protein; R2 is H, OH, NH2, among others; R3 and R4 are each independently selected from H, NH2, halo, among others; R5 is H, NH2, halo, among others; X is NH2, C1-6 alkoxy, C1-6 alkyl, among others; Y is -L-Y1 or Y1; Y1 is H, NH2, halo, cyano, among others; L is in a bond, O, S and N(La); La is H and C1-3 alkyl; U is C(R6a); V is C(R6b); W is C(R6c) or N; each of R6a, R6b and R6c is independently selected from H, OH, NH2, among others; yn is 0, 1 and 2.