L-GLUTAMIC ACID PRODUCING BACTERIA AND METHOD FOR PRODUCING L-GLUTAMIC ACID

Abstract

A method for the production of L-glutamic acid, comprising cultivating Corynebacterium glutamicum capable of producing L-glutamic acid in a culture medium, accumulating it in the medium and / or in the cells, and collecting it. The bacterium has been modified to harbor a mutant glyA gene encoding a mutant serine hydroxymethyltransferase with the substitution of a glycine residue at position 265 of the wild-type sequence with a serine residue, comprising the amino acid sequence of SEQ ID NO: 4. The mutant glyA gene comprises the nucleotide sequence of SEQ ID NO: 3 or a variant thereof due to degeneracy of the nucleotide sequence. Additionally, the coryneform bacterium may harbor a mutant yggB gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 10.