4-AMINOQUINOLINE-3-CARBONITRILE COMPOUNDS WITH CO2 MODULATING ACTIVITY

Abstract

The present invention relates to a compound of formula II, wherein R1 is -C1-9 alkyl; R2 is hydrogen; R3a is C3-15 cycloalkyl optionally substituted with a substituent selected from C1-8 haloalkyl; in R4, which is either 1 or 2, each Z4 is independently selected from the group consisting of halo and C1-9 alkyl; Z9 is hydrogen; R5 is halo or -CN; R6 is -C(O)O-R16-OP(O)(OR12)2, -C(O)O-R16-OR17, -C(O)O-R16-OH, -C(O)O-R16-OC(O)R17, -C(O)-C(O)OR12, or -C(O)O-R16-OC(O)R17NH2; each R12 is hydrogen; R16 is -C1-3 alkylene; and R17 is a C1-9 alkyl or C2-12 heterocyclyl group with 1-3 heteroatoms in the ring selected independently of N, O, and S, optionally substituted with a C1-3 alkyl group; or a pharmaceutically acceptable salt thereof. The invention also relates to a composition comprising the compound, or a pharmaceutically acceptable salt thereof.This compound modulates the expression or activity of the Cot protein and may be useful in the treatment of diseases, disorders, or conditions associated with the activity of this protein.