NLRP3 inflammasome inhibitors

PH12021552885B1Active Publication Date: 2026-08-12NOVARTIS AG

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Patent Information

Application Number: PH12021552885
Authority / Receiving Office: PH · PH
Patent Type: Patents
Current Assignee / Owner
Filing Date: 2021-11-15
Publication Date: 2026-08-12
Estimated Expiration: 2041-11-15

Application Information

Patent Timeline

15 Nov 2021

Application

PH12021552885

12 Aug 2026

Publication

PH12021552885B1

Inventors: GOMMERMANN, Nina; FARADY, Christopher

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Abstract

The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1 , R2 , R3 , R4 , R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.

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