Compounds and methods of use thereof as antibacterial agents

Abstract

The present invention relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one dihydroisoxazole compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of a dihydroisoxazole of the invention and / or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and / or salt.