Genetic markers for predicting susceptibility and diagnosis of type 2 diabetes mellitus

Abstract

Type 2 diabetes mellitus (T2DM) is a prevalent public health problem that leads to long-term and costly complications to the afflicted. Thus, prevention of the condition by predicting at-risk individuals make it possible for the latter to implement protective strategies such as dietary and activity modification. In this invention, a set of genetic markers associated with the presence of T2DM is presented that can be used to identify susceptible people, especially among Filipinos. The markers include rs10497721 and rs12150053. Other markers include rs7119, rs7766070, rs70827, rs2383208, rs391300 and rs65936. By conferring an odd ratio of 2 or more, single or a combination of the above markers may serve as prognostication markers for the identification of at-risk individuals.