Substituted N-(amino-heteroaryl)-1H-indole-2-carboxamide compound, preparation thereof

Abstract

The invention relates to compound of general formula (I): in which X1 represents a hydrogen or halogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, cyano, C(0)NR1R2, nitro, C1-C6-thioalkyl, -S(O)-C1-C6-alkyl, -S(O)2-C1-C6-alkyl, SO2NR1R2, aryl-C1-C6-alkylene, aryl or heteroaryl, the aryl and the heteroaryl being optionally substituted; X2 represents a hydrogen or halogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C3-C7-cycloalkyl-C1-C6-alkylene-O-, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, C1-C6-thioalkyl, -S(O)-C1-C6-alkyl, -S(O)2-C1-C6-alkyl, SO2NR1R2, aryl- C1-C6-alkylene, aryl or heteroaryl, the aryl and the heteroaryl being optionally substituted; X3 and X4 represent, independently of each other, a hydrogen or halogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C,-C6-alkoxyl, C3-C7-cycloaIkyl-C1-C6-alkylene-O-, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, -S(O)-C1-C6-alkyl, -S(O)2-C1-C6alkyl, SO2NR,R2, NR3COR4, NR3SO2R5, aryl-C1C6-alkylene, aryl or heteroaryl, the aryl and the heteroaryl being optionally substituted; Z1, 22, Z3 and Z4 represent, independently of each other, a nitrogen atom or a group C(R6); n is equal to 0, 1, 2 or 3; Y represents an optionally substituted aryl or heteroaryl; Ra and Rb represent, independently of each other, a hydrogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, hydroxyl, C1-C6-alkoxyl, C3-C7-cycloalkyl-C1-C6 fluoroalkoxyl, aryl or heteroaryl, Ra and Rb possibly being substituted. Preparation process and therapeutic use.