Substituted 2-carbonylamino-6-piperidinaminopyridine

Abstract

The present invention relates to compound of formula I: X is-C(R3c)=or-N=; R 1 is C2-C6 alkyl, substituted C2-C6 alkyl, C3-C7-cycloalkyl, substituted C3-C7 cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R 2 is hydrogen, n-alkyl, cycloalkyl-C1-C3 alkyl, or a group of formula provided that when R1 is C2-C6 alkyl or substituted C2-C6 alkyl, R2 is hydrogen or methyl; R 3a, R3b , and. when X is –C(R3c)=, R3c, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R3a, R3b, and R3c may be other than hydrogen; R 4 is hydrogen or C1-C3 alkyl; R 5 is hydrogen, C1-C3 alkyl, or C3-C6 cycloalkylcarbonyl, provided that when R3a is other than hydrogen, R5 is hydrogen; R 6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compound of the present invention is useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.