Process for the synthesis of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide(agomelatine)

Abstract

Process for the industrial synthesis of the compound of formula (I) characterised in that 3-methoxyacenaphthoquinone of fonnula (II) is reacted in the presence of a strong base to yield the compound of formula (III) which is subjected to amination to yield the compound of formula (IV) which is subjected to the action of a reducing system to yield the compound of formula (V) action of sodium acetate and then acetic anhydride to yield the compound of formula (I), which is isolated in the form of a solid.