A 15β-subsitituted steroidal compound.

Abstract

The invention provides 15β-substituted steroidal compound / 6 having selective estrogen receptor activity according to Formula1: Wherein, R1 is H, C1-5 alkyl, C1-12acyl,di-(C15alkyDaminocarbonyl,(C1-5alkyl)oxycarbonyl or sulfamoyl, R2 is H, C1-3alkyl, C2-3alkenyl or C23alkynyl, each of which may be optionally substituted with a halogen, R3 is C1-2 alkyl, ethenyl or ethynyl, each of which may be optionally substituted with a halogen, and R4 is H or C1-12acyl.