Process for the preparation of pyrimidine compound.
PK140907AUndetermined Publication Date: 2010-09-20JANSSEN PHARMA NV
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Patent Information
- Application Number
- PK201000689
- Authority / Receiving Office
- PK · PK
- Patent Type
- Applications
- Current Assignee / Owner
- Publication Date
- 2010-09-20
Abstract
The present invention concerns the preparation of the compound of formula (A1)(A2)N-RI (1), the quaternary amine, where R1 is substituted C1-6a1ky1;-S(=O) R8 ; -S(=O)2-R8 ;C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1¬6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1 ; (A1)(A2)N- is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N-H, which is a HIV replication inhibiting pyrirnidine of formula
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