A monoclonal antibody specific to human tyrosinase-related protein-1(tyrp1)

Abstract

The present invention provides for a monoclonal antibody that specifically binds human TYRP1, comprising a VH comprising the amino acid sequence: QVQLVQSGSELKKPGASVKISCKASG YTFTSYAMNWVRQAPGQGLESMG WINTNTGNPTYAQGFTGRFVFSMDTS VSTAYLQISSLKAEDTAIYYCAPRYSSS WYLDYWGQGTLVTVSS, a CDRL1 having the sequence RASQSVSSYLA, a CDRL2 having the sequence DASNRAT, and a CDRL3 having the sequence QQRSNWLMYT. The invention further provides polynucleic acids and host cells that encode and express this antibody. The invention also provides a pharmaceutical composition comprising an antibody either alone or in combination with an anti-cancer agent for modulating activity of TYRP1, treating growth of a cancer cell, and treating a malignant melanoma in mammals