Substituted 2-OXO-1-Pyrrolidine Compound

Abstract

The invention concerns a compound having a general formula (A), wherein X is -CONR5R6 or -COOR7 or -CO-R8 or CN: R1 is hydrogen or alkyl, aryl, heterocycloalkyl heteroaryl, halogen, hydroxy, amino, nitro, cyano; R2 and R4 are the same or different and each is independently hydrogen or halogen, hydroxy, amino, nitro, cyano, acyl, acyloxy, -S02-alkyl, -S02-aryl, -SO-alkyl, SO-aryl, alkylamino, carboxy, ester, ether, amido, sulfonic acid, sulfonamide, alkoxycarbonyl, alkylthio, arylthio, alkyl, alkoxy, oxyester, oxyamido, aryl, arylamino, aryloxy, heterocycloalkyl, heteroaryl, vinyl; R3 is hydrogen, halogen, hydroxy, amino, nitro, cyano, acyl, acyloxy, -S02-alkyl, S02-aryl, -SO-alkyl, -SO- aryl, alkylamino, carboxy, ester, ether, amido, sulfonic acid, sulfonamide, alkoxycarbonyl, alkylthio, arylthio, alkyl, alkoxy, oxyester, oxyamido, aryl, arylamino, aryloxy, heterocycloalkyl, heteroaryl, (C2-05)alkenyl, (C2 05)alkynyl, azido, phenylsulfonyloxy wherein each (C2-05)alkenyl, (C2 05)alkynyl may independently be optionally substitut¬ed by one or more halogen, cyano, thiooyano, azido, alkylthio. cyclopropyl, acyl, and / or phenyl; R5, R8, R7 are the same or different and each is independently hydrogen, hydroxy, alkyl, aryl, heterocycloalkyl , heteroaryl, alkoxy, aryloxy; and R8 is hydrogen, hydroxy, thiol, halogen, alkyl, aryl, heterocycloalkyl , heteroaryl, alkylthio, arylthio; each alkyl contains 1-20 carbon atoms and has straight, branched or cyclic moieties or combinations thereof and may be optionally substituted by 1 to 5 substituents independently selected from halogen, hydroxy, thiol, amino, nitro, cyano, acyl, acyloxy, -S02-aryl, -SO2-alkyl, -SO-aryl, alkylarnino, carboxy, ester, ether, amido, sulfonic acid, sulfonamide, alkoxycarbonyl, alkylthio, arylthio, oxyester, oxyamido, heterocycloalkyl, heteroaryl, vinyl, (C1-05)alkoxy, (C6 C10)aryloxy, (C6-C10)aryl; each aryl may be optionally substituted by 1 to 5 substituents independently selected from halogen, hydroxy, thiol, amino, nitro, cyano, acyl, acyloxy, -S02-alkyl, -S02-aryl, -SO-alkyl, -SO-aryl, alkylamino, carboxy, ester, ether, arnido, sulfonic acid, sulfonamide, alkoxycarbonyl, alkylthio, oxyester, oxyamido, aryl, (C1-C6)alkoxy, (C6-C10) aryloxy, (C1-06)alkyl; with the proviso that the compound is not methyl 2-(4R,S-isopropyl-2-oxo pyrrolidin-1-y1) acrylate, methyl 2-(3R,S chloro-4 R,S-isopropyl-2-oxopyrrolidin-1 yl) acrylate or methyl 2-(2-oxo-pyrrolidin 1-yl)-acrylate.