A compound comprising n-(2-fluoro-4{[2- ({[4-(4-methylpiperazin-1-yl)piperidin1- yl]carbonyl}amino)pyridin-4yl]oxy}phenyl)- n’-(4fluorophenyl)cyclopropane-1,1dicarboxamide.

Abstract

A compound represented by the formula N-(2-Fluoro-4-{[2-({[4- (4-methylpiperazin-lyl)piperidin-1-yl]carbonyl}amino)pyridin-4- yl] oxy} pheny1)- N'- ( 4fluorophenyl)cyclopropane-1,1dicarboxamide has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered nonaromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4 , R5 , R6 , and R7 may be the same or different and each represents hydrogen, halogen, C1 -6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered nonaromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents - CH=, nitrogen or the like.]