A salt of a compound comprising n-(2fluoro-4-{[2-({4-(4-methylpiperazin-1yl)piperidin-1-yl]carbonyl}amino)pyridin4-yl]oxy}phenyl)-n'-(4fluorophenyl)cyclopropane-1,1dicarboxamide.
PK141002AUndetermined Publication Date: 2010-11-03EISAI R&D MANAGEMENT CO LTD
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Patent Information
- Application Number
- PK200800375
- Authority / Receiving Office
- PK · PK
- Patent Type
- Applications
- Current Assignee / Owner
- Publication Date
- 2010-11-03
Abstract
A salt of a compound represented by the following formula, an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [RI represents a 3- to 10-membered nonaromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4 , R5 , R6 , and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered nonaromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.]
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