Humanized Antibodies That Recognise Beta Amyloid Peptide

Abstract

A humanized immunoglobulin which specifically binds beta amyloid peptide (Aβ), or antigen binding fragment thereof, the humanized immunoglobulin or antigen binding fragment comprising: (i) a light chain comprising complementarity determining regions (CDRs) from the 3D6 immunoglobulin light chain variable region sequence set forth as SEQ ID NO:2, and a variable framework region substantially from a human acceptor immunoglobulin light chain sequence; and (ii) a heavy chain comprising complementarity determining regions (CDRs) from the 3D6 immunoglobulin heavy chain variable region sequence set forth as SEQ ID NO:4, and a variable framework region substantially from a human acceptor immunoglobulin heavy chain.