Combination therapy for pancreatic cancer using an antigenic peptide and chemotherapeutic agent

Abstract

Described herein is an anti-cancer composition For treating cancer by CTL induction in a subject comprises (i) in combination with (ii); (i) one or more peptides selected from the group consisting of; (a) one or more peptides having the amino acid sequence selected from the group consisting of rfvpdgnri (seq id no: 1), vysseeael (seq no: 2), gyriydvvl (seq id no: 3), symisyagm (seq id no: 4), kwefprdrl (seq id no: 5), dfltlehli (seq id no: 6), (b) the peptide of (a), wherein 1, 2, or several amino acids are substituted, deleted, or added, and wherein said peptide having cytotoxic T cell inducibility; (c) the peptide of (b), wherein the second amino acid from the N-terminus is phenylalanine, tyrosine, methioaine, or tryptophan; (d) the peptide of (b) or (c) , wherein the C-terminal amino acid is phenylalanine, leucine, isoleucine, tryptophan, or methionine; (e) one or more peptides having the amino acid sequence selected from the groupconsisting of anffwlllv (seq id no: 7), viamffwll (seq id no: 8), aviamffwl (seq id no: 9), klieigvqt (seq id no: 10), ymisyagmv (seq id no: 11), iqsdvwsfgv (seq id no: 12) and vlamffwll (seq id no: 13); (f) the peptide of (e), wherein 1, 2, or several amino acids are substituted, deleted, or added, and wherein said peptide having cytotoxic T cell inducibility; (g) the peptide of (f), wherein the second amino acid from the N terminus is leucine or methionine; and (h) the peptide of (I) or (g), wherein the C-terminal amino acid is valine or leucine, (ii) one or more chemotherapeutic agents selected from the group consisting of gemcitabine, a pharmaceutically acceptable salt thereof, and a prodrug thereof.