Non-norcotic antitussive in syrup and drops dosage form

Abstract

The anti-tussive dimemorphan was discovered through extensive screening of morphine derivatives. The antitussive action of dimemorphan appears to be directly on the cough centre in the medulla. Dimemorfan does not induce any significant physical or psychological dependence and its antitussive action is not affected by opioid-receptor blocker levllorphan. Dimemorfan is therefore considered as a non-norcotic antitussive agent. Dimemorfan phosphate is three times more potent than codeine & is equivalent to dextromethorphan. Dimemorfan is equally or slightly more efficacious than dextromethorphan, beproperine phosphate for the control of cough. In contrast to the narcotic antitussives, dimemorfan causes no serious problems. The clinical studies indicate that dimemorphan is effective non¬norcotic antitussive agent with low incidence of adverse effects. Its composition & formulation in syrup form is unique in nature because of specially designed solvent system by Amson which ensures maximum availability & safety & its presentation in soluble form.