Substituted 5-oxido-4-phenylsulphonyl-1,2,5 oxadiazol compound

Abstract

Compound of formula (Id) wherein B belongs to the following formula (III) X-(Ak1)x-(Y)y-(Ak2)z-Z (III) wherein X represents a CO2H, SO3H or P(O)(OH)2 group, Ak1 and Ak2, which may be identical or different, each represents a saturated or unsaturated, linear or branched C1-C8alkylene group in which one or more of the carbon atoms may be replaced by an oxygen, sulphur or nitrogen atom or by an SO2 group, the said alkylene group optionally being substituted by one or more groups selected from CO2H, SO3H, hydroxy and amino, x, y and z, which may be identical or different, each represents 0 or 1, Y represents CO or CONH, Z represents an NO donor group, and a pharmaceutical composition comprising thereof, are described.