Inhibition of macrophage-stimulating protein receptor (Ron)

Abstract

The invention provides an antibody or fragment thereof that specifically binds to a human RON protein, wherein said antibody or fragment thereof comprises a CDRH1 having a sequence GFTFSSYLMT (SEQ ID NO: 29), a CDRH2 having a sequence NIKQDGSEKYYVDSVKG (SEQ ID NO: 31), a CDRH3 having a sequence DGYSSGRHYGMDV (SEQ ID NO: 33), a CDRL1 having a sequence RASQSVSRYLA (SEQ ID NO: 35), a CDRL2 having a sequence DASNRAT (SEQ ID NO: 37) and a CDRL3 having a sequence QQRSNWPRT (SEQ ID NO: 39) and has a KD of 3.2 x 10-11 M. Also provided is a pharmaceutical composition comprising said RON antibody to treat diseases such as cancer.