Aromatic boron-containing compound, method of making same and pharmaceutical composition thereof

Abstract

The present invention relates to method of producing a novel compound of formula (I). wherein: Xl comprises a drug substance comprising an amine; an amine configured to be covalently conjugated to a drug substance; or NH2 or OH; each Z1a independently comprises 1 to 50 amino acids connected together using amide or peptide bonds; each Z1b is independently a small-molecule linker; each Z1c is independently selected from Formulae FF12, FF12A, FF12B, FF12C, FF12D, FF114, FF114A, FF114B, FF115, FF115A, FF115B, FF116, FF116A, FF116B, FF116C, FF116D, FF117, FF193A, FF203, FF225, FF225A, FF225B, and FF226. The compound further include one or more aromatic boron-containing groups. The present invention also relates to pharmaceutical compositions comprising the disclosed compound, which is therapeutically effective for treating diabetes and obesity, for controlling blood sugar level and for control of release of drug etc.