Composition, method and system for aerosol drug delivery

Abstract

Composition, method, and system are provided for pulmonary delivery of an active agent via a metered dose inhaler. In some embodiment, the composition comprises an HFO-1234ze(E) suspension medium, active agent particle, and suspending particle. The active agent particle may comprise one, two, three, or four active agent(s) selected from a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonist (LABA),a short-acting beta-agonist (SABA), an inhaled corticosteroid (ICS), and a non-corticosteroid anti-inflammatory agent