Anti-extended type 1 glycosphingolipid antibody, derivatives thereof and use

Abstract

Human antibodies and antigen-binding portions of those antibodies that specifically bind extended Type I chain glycosphingolipids are provided. A human monoclonal antibody or antigen binding portion thereof that specifically binds an epitope comprising an extended Type I chain containing Leb, wherein said epitope is expressed on a cancer cell, wherein said antibody or antigen binding portion thereof does not bind to Ley, and wherein the antibody has a heavy chain variable region having the amino acid sequence that has 80%-100% identity with SEQ ID NO: 15, and a light chain variable region having the amino acid sequence that has 80%-100% identity with SEQ ID NO: 17.