Spiro-oxindole commpounds and their use as therapeutic agents

Abstract

This invention is directed to a compound of formula (I): wherein: n is 1 or 2; one of J and K is -CH2- and the other is -O-; or both J and K are each -CH2-; R 1 is (6-methylpyridin-2-yl)methyl, pyridin-3ylmethyl, diphenylmethyl, pentyl, isopentyl, (5(trifluoromethyl)furan-2-yl)methyl, tetrahydrofuran-2-ylmethyl, 3-methylbutyl, tetrahydro-2H-pyran-4-ylmethyl, tetrahydro-2Hpyran-2-ylmethyl, (5-chloro-1 -methyl-1 Himidazol-2-yl)methyl, pyridin-2-ylmethyl, (2R)-1 ,4-dioxan-2-ylmethyl, 1 ,4-dioxan-2-ylmethyl, 3,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, 2, 3dihydro-1 ,4-benzodioxin-6-ylmethyl, [5(trifluoromethyl)furan-2-yl]methyl, 3(trifluoromethyl)benzyl, (5methoxycarbonylfuran-2-yl)methyl, 2-(2methoxyethoxy)ethyl, 5-carboxyfuran-2-ylmethyl, 5-(dimethylaminocarbonyl)furan-2ylmethyl, 3(trifluoromethyl)pyridin-2-yl]methyl or (5hydroxypyridin-2-yl)methyl; each R2 is hydrogen; or two adjacent R2 's, together with the adjacent carbons to which they are attached, form a fused thiazolyl ring or a fused dioxinyl ring.