Pharmaceutically acceptable salt of a substituted piperidinyl-sulfonyl compound

Abstract

This invention relates to a pharmaceutically acceptable salt of a compound according to Formula (I): wherein inter alia X is selected from the group consisting of halogen, C1-3alkyl, C1-3alkoxy, cyano, CF3, and OCF3; R2 is selected from the group consisting of C3-6 cycloalkyl, phenyl and heteroaryl, wherein the phenyl or heteroaryl moieties are optionally substituted, once or twice, independently, by a substituent selected from the group consisting of C1-3alkyl, halogen, CF3, OCF3, phenyloxy and benzyloxy; or R2 represents phenyl substituted by methylenedioxy or by (di-halo-substituted)-methylenedioxy; R1 is C4-8heterocyclyl(CH2)n- wherein the heterocyclyl moiety is a pyrrolidin-2-yl, pyrrolidin-3-yl, piperidin-4-yl, piperidin-3-yl, or azetidin-3-yl, each moiety optionally substituted independently once or twice by a substituent selected from the group consisting of C1-3 alkyl, C(O)OR4 and C(O)R5; R4 and R5 are, independently selected from a C1-3alkyl; andn is 0 or 1; useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8); and pharmaceutically composition comprising thereof.