Process for the preparation of eplivanserin hemifumarate

Abstract

Process for the preparation of eplivanserin hemifumarate, characterized in that the eplivanserin base is isomerized and crystallized, by the action of fumaric acid, in the presence of a polar solvent, the boiling point of which is greater than 100°C, or of a mixture of polar solvents, the boiling point of which is greater than 100°C, by the following stages:i) heating the eplivanserin base in the presence of fumaric acid and then cooling,ii) seeding,iii) lowering the temperature via stationary phases,iv) filtering and washing.