Derivatives of pyridino-pyridinones, preparation thereof and application thereof in therapeutics

Abstract

The invention relates (i) to a compound corresponding to formula (I): in which R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 represents a group -(CH2)n'-B where n'=0, 1, 2, 3 or 4 and B represents a (C3-C5)cycloalkyl group, a (C1-C4)alkyl group or a (C1-C4)alkoxy group; Y, Z, V and W represent, independently of one another, a -CH- group, a carbon atom, a heteroatom or no atom, it being understood that the ring in which V, W, Y and Z are comprised is a ring comprising 5 or 6 ring members, it being understood that the dotted lines in said ring indicate that the resultant ring is an aromatic ring and it being understood that said ring comprises 0, 1 or 2 heteroatoms; R3 and R4 represent, independently of one another, groups that may be identical or different, selected from a hydrogen atom and a linear (C1-C4)alkyl group or form, together with the carbon to which they are bound, a (C3-C5)cycloalkyl group; m is an integer equal to 1, 2, 3 or 4; R5 represents a hydrogen atom or a (C1-C4)alkyl group; R6 represents a group -(CH2)n-L in which n= 0, 1, 2 or 3, and L is a group selected from aryls with 6 carbon atoms, heteroaryls with 5 or 6 ring members, saturated heterocycles comprising 5, 6 or 7 ring members or form, together with the nitrogen atom to which they are bound, a heterocyclic group, (ii) to its preparation and (iii) to pharmaceutical compositions comprising thereof for use as inhibitors of kinase activity of receptors for PDGF ligands and / or of receptors for the FLT3 ligand.