Non-nucleoside reverse transcriptase inhibitors

Abstract

Heteroaromatic compounds of Formula I:are HIV reverse transcriptase inhibitors, wherein R 1 , R2 , R3 , R4 and R5 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.