Ester and salt of c2‐c5‐alkyl‐substituted [(imidazol‐1‐yl)‐1‐hydroxy‐1‐phosphono‐ethyl]‐ phosphonic acid.

Abstract

Ester and / or salt of C2-C5-alkyl-substituted [(imidazol-1-yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid, as well as method or process for their manufacture, their use in the manufacture of pharmaceutical formulations, pharmaceutical formulations encompassing them and / or the esters and / or salts of compounds for use in the treatment of diseases, are described. The esters and / or salts of the compounds are able to inhibit excessive or inappropriate bone resorption and for the treatment of other diseases which are caused by excessive prenylation of target proteins, such as Hutchinson-Gilford progeria syndrome. The esters and / or salts of the compounds are of the formula I, wherein one of R1 and R2 is hydrogen and the other is C2-C5-alkyl that is branched or unbranched.