Phenylthioacetate compositions and methods of use

Abstract

The present invention relates to a compound of formula (I): wherein: each R1, R2, R3 and R4 is selected from H, halogen, -CN, Cl to C6 alkyl, Cl to C6 alkoxy, C3 to C7 cycloalkyl or a C-attached heterocycle; Ra and Rb are selected from H, halogen, Cl to C6 alkyl; or Ra and Rb, together with the carbon atom to which they are attached, form a 3-, 4-, 5- or 6membered ring, optionally containing one or two heteroatoms selected from 0 , N and S; M is H, Cl to C4 alkyl or a pharmaceutically acceptable cation; W is CRW; wherein Rw is H, CN, CF3, CH3, OCH3, F or Cl; X is CRx; wherein Rx is H, halogen, -CN, Cl to C6 alkyl, Cl to C6 alkoxy, C3 to C7 cycloalkyl, -OH, -SH, -S(C1 to C6 alkyl), CH20H, COORX', CONHRX' or S02NH2; wherein R* is H, or Cl to C6 alkyl; RY is H, halogen, -CN, Cl to C6 alkyl, or Cl to C6 alkoxy; Rz is H, halogen, -CN, Cl to C6 alkyl, or Cl to C6 alkoxy; provided that at least one of R1, R2, R3, R4, Rw, Rx, RY or Rz is not H; provided that if R2 is Cl, then Rx is not SEt; and provided that if R2 is Cl, then Rw is not CN. Also provided is a composition containing the compound. The compound is useful in the modulation of blood uric acid levels. In some embodiments, the compound described herein is used in the treatment or prevention of disorders related to aberrant levels of uric acid.