Anti-tie2 antibodies and uses thereof

Abstract

The present invention provides antibody that specifically binds human Tie2 (tyrosine kinase receptor) and block the interaction between Tie2 and one or more Tie2 ligands such as angiopoietin 1 (Angl), angiopoietin 2 (Ang2), angiopoietin 3 (Ang3) and / or angiopoietin 4 (Ang4). The present invention further provides a pharmaceutical composition comprising the said antibody along with pharmaceutical acceptable carrier or diluent. The antibody of the invention is useful, inter alia, for the treatment of diseases and disorders associated with one or more Tie2 biological activities including angiogenesis.