Gel formulations with combinations of meloxicam, dexamethasone, levofloxacin, arctium lappa l. (burdock) extract, thymus vulgaris l. (THYME) extract, to be used for human and veterinary medical use

Abstract

The invention relates to a process for preparing gels with anti-inflammatory, wound-healing and antimicrobial effects, for topical administration, intended for human and veterinary use. According to the invention, the process comprises the following steps: 1.- preparing a gel base by dispersing Carbopol in purified water and neutralizing it with triethanolamine, 2.- preparing the active phase by dissolving a hydrosoluble component, such as levofloxacin in purified water and solubilizing the lipophilic or poorly soluble components, such as dexamethasone, meloxicam, essential oils in a mixture of PEG 400-Polysorbate 80-glycerin and adding glycerinated plant extracts of thyme and burdock, 3.- incorporating the active phase in the gel base with slow mechanical stirring, up to homogenization, resulting in products with gel or emulgel appearance, with stable pseudoplastic texture, pH 5.8⋯6.5, with maximum anti-inflammatory effect 3⋯4 h after induction of inflammation and healing effect expressed as accelerated dynamic overall evolution of the complete healing process.