Compositions and methods for the treatment and prophylaxis of surgical site infections

Abstract

A biodegradable substrate impregnated with or having its surface coated in whole or in part with a matrix composition comprising (a) a biodegradable polyester, (b) a first lipid component comprising at least one sterol non-covalently linked to the biodegradable polyester, (c) a second lipid component comprising at least one phospholipid having fatty acid moieties of at least 12 carbons; and (d) an antibiotic agent selected from doxycycline and doxycycline hyclate, for use in the treatment or prophylaxis of incision site infection associated with surgical operation in a subject in need thereof, wherein the substrate is a mineral substrate in particulate form. The application contains 16 more claims.