BIOREACTOR DEVICE

Claims

1. A bioreactor device comprising: a vessel for containing liquid and gas from free space and a Venturi pump block, wherein the Venturi pump block comprises: outlet pipe for the medium, inlet pipeline for the medium, a pumping device designed to suck a medium from a vessel through an outlet pipeline for the medium and feed it into an inlet pipeline for the medium, and a foam collector comprising an inlet pipe located inside the vessel in a position on the surface of the liquid medium, and a narrowed neck, where the inlet pipeline for the medium is adapted to direct the pumped medium through the neck of the foam collector to create a region of reduced pressure in it for sucking surface foam into the inlet pipe of the foam collector.

2. The bioreactor device according to claim 1, in which the inlet pipeline for the medium is arranged so that it enters the inlet pipe of the foam collector and directs the pumped medium through the neck.

3. A bioreactor device according to any of the preceding claims, wherein the pumping device is located outside the vessel.

4. A bioreactor device according to any of the preceding claims, in which the inlet pipe is adapted, in the direction of the pumped medium through the neck of the foam collector, creating a region of reduced pressure in it, for sucking gas from the free space into the inlet pipe of the foam collector.

5. A bioreactor device according to any of the preceding claims, comprising a mixing device for mixing any of the foam, gas from the headspace and liquid medium from the foam collector.

6. The bioreactor device according to claim 5, wherein the mixing device is located downstream of the foam collector.

7. The bioreactor device according to claim 6, wherein the mixing device is fed at least through the first intermediate pipeline for the medium from the foam collector.

8. The bioreactor device according to claim 6 or 7, wherein the mixing device comprises an impeller, and the impeller is adapted to pass any of the foam, gas from the headspace and / or liquid medium through the mixing device, and / or to grind a mixture of any of the foam, gas from the headspace and / or liquid medium.

9. A bioreactor device according to any one of claims 5 to 8, wherein the mixing device is adapted to create a region of reduced pressure for sucking the contents of the vessel into the mixing device.

10. A bioreactor device according to any of the preceding claims, comprising an additional foam collector that is separate from the foam collector.

11. The bioreactor device according to claim 10, wherein the foam collector and the additional foam collector are located at different levels in the vessel.

12. The bioreactor device according to claim 10 or 11, in which the additional foam collector is located in the vessel at a lower position so that when used with an increase in the height of the foam in the vessel, the foam reaches the foam collector before the collector.

13. A bioreactor device comprising: a vessel for containing a liquid medium and a Venturi pump unit, wherein the Venturi pump unit comprises: outlet pipeline for the medium, inlet pipeline for the medium, a pumping device designed to suck a medium from a vessel through an outlet pipeline for the medium and feed it into an inlet pipeline for the medium, a collector containing an inlet pipe and a narrowed neck, and a mixing device located downstream of the collector, wherein the inlet pipeline for the medium is adapted to direct the pumped medium through the neck of the collector to create a region of reduced pressure in it for sucking the contents of the vessel into the inlet pipe of the collector, and the mixing device is adapted to mix the contents of the vessel collected by the collector.

14. The bioreactor device according to claim 13, wherein the mixing device is fed at least through the first intermediate pipeline for the medium from the collector.

15. The bioreactor device according to claim 13 or 14, wherein the mixing device comprises an impeller, and the impeller is adapted to pass any of the foam, gas from the headspace and / or liquid medium through the mixing device, and / or to grind a mixture of any of the foam, gas from the headspace and / or liquid medium.

16. The bioreactor device according to claim 14 or 15, wherein the pumping device comprises a first drive means and the mixing device comprises a second drive means.

17. A bioreactor device according to any of the preceding claims, comprising a special foam collector, including an inlet pipe located on the surface of the liquid medium opposite the position on the surface of the foam collector.

18. The bioreactor device according to claim 13, wherein the mixing device comprises an impeller, and wherein the bioreactor device comprises a special foam collector, including an inlet pipe located on the surface of the liquid medium opposite the position on the surface of the foam collector, and wherein a pipeline of the special foam collector is connected to the special foam collector and the impeller housing, wherein the impeller is additionally adapted to create a region of reduced pressure for sucking foam from the surface into the inlet pipe of the special foam collector.

19. A bioreactor device according to claim 17 or 18, wherein the special foam collector contains a narrowed neck.

20. A bioreactor device according to any of the preceding claims, wherein the pumping device is located outside the vessel.

21. A bioreactor device comprising: a vessel for containing liquid and gas from free space and a Venturi pump block, wherein the Venturi pump block comprises: a foam collector having an inlet pipe and a narrowed neck, a pipeline for the medium located inside the foam collector concentrically around the narrowed neck, and a pumping device, wherein the pumping device is adapted to pump a medium from a vessel through a medium pipeline, thereby creating a low pressure region for sucking surface foam and / or gas from the free space into the inlet of the foam collector.

22. A system for maintaining environmental conditions inside a closed chamber, comprising: ambient gas compressor and a first sterilization unit configured to receive gas from a compressor, heat the gas to a predetermined sterilization temperature, cool the gas to a predetermined temperature inside the chamber, and supply the sterilized gas to a closed chamber.

23. The system of claim 22, wherein the closed chamber is under pressure.

24. The system of claim 22 or 23, wherein the closed chamber is a bioreactor.

25. The system according to any one of paragraphs 22-24, in which the first sterilization unit comprises an intermediate chamber configured to receive gas heated to a predetermined sterilization temperature and to discharge gas to be cooled to a predetermined temperature inside the chamber.

26. The system of claim 25, wherein the intermediate chamber comprises a spiral pipeline, the pipeline comprising an inlet end for receiving heated gas and an outlet end for discharging gas to be cooled.

27. The system according to any one of paragraphs 22-26, comprising a second sterilization unit configured to receive gas from a closed chamber and heat the gas.

28. The system of claim 27, wherein the second sterilization unit is configured to cool the gas to a predetermined ambient temperature after heating the gas.

29. A bioreactor system comprising: a bioreactor device according to any one of paragraphs 1-21 and a system according to any one of paragraphs 22-28.

30. Use of a bioreactor device according to any of paragraphs 1-21 or a system according to any of paragraphs 22-29 in a fermentation process.

31. A method of processing in a bioreactor, comprising: providing a vessel for containing a liquid medium and a Venturi pump unit, wherein the Venturi pump unit comprises an outlet pipeline for the medium, an inlet pipeline for the medium, a pumping device, an inlet element comprising an inlet branch and a neck, and a mixing device; using a pumping device to draw the medium from the vessel through the medium outlet pipe and feed it into the medium inlet pipe, directing the pumped medium through the neck of the inlet element to create a region of reduced pressure in it for sucking the contents of the vessel into the inlet branch of the inlet element, and using a mixing device to stir the contents of a vessel collected by an inlet element.

32. The method for processing in a bioreactor according to paragraph 31, comprising: providing an ambient gas compressor and a sterilization unit; receiving gas from the compressor into the sterilization unit; heating the gas to a predetermined sterilization temperature and supplying sterilized gas to the vessel.

33. A method for processing in a bioreactor according to claim 31 or 32, comprising: providing an extended heating portion; receiving incoming gas; narrowing the flow of incoming gas using the extended heating portion; heating the gas to a predetermined sterilization temperature using the extended heating portion; and supplying the sterilized gas to a vessel.