Method for producing cobalt(II) homopantothenate ascorbate
The new method addresses inefficiencies in cobalt(II) homopantothenate ascorbate production by reacting cobalt(II) homopantothenate and cobalt(II) ascorbate in an aqueous solution, achieving high yields of pure cobalt(II) homopantothenate ascorbate through evaporation and precipitation, thereby improving purity and efficiency.
Patent Information
- Authority / Receiving Office
- RU · RU
- Patent Type
- Patents
- Current Assignee / Owner
- FEDERALNOE GOSUDARSTVENNOE KAZENNOE VOENNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIYA VOENNAYA ACADA RADIATSIONNOJ KHIMICHESKOJ I BIOLOGICHESKOJ ZASHCHITY IMENI MARSHALA SOVETSKOGO SOYUZA S K TIMOSHENKO G KOSTROMA MINISTSTVA OBORONY ROSSIJSKOJ FEDERATSII
- Filing Date
- 2025-06-18
- Publication Date
- 2026-07-01
AI Technical Summary
Existing methods for producing cobalt(II) homopantothenate ascorbate suffer from inefficiencies such as the need for time-consuming separation of calcium sulfate by-products and incomplete removal, leading to impurities and reduced yield.
A new method involving the reaction of equimolar cobalt(II) homopantothenate and cobalt(II) ascorbate in an aqueous solution with mechanical stirring, followed by evaporation and precipitation with acetone to obtain a pure cobalt(II) homopantothenate ascorbate.
The new method achieves high yields of 93-94% pure cobalt(II) homopantothenate ascorbate, free from calcium sulfate impurities, through a simplified and efficient production process.
Abstract
Description
[0001] The invention relates to the chemistry of complex compounds, in particular, to the production of cobalt(II) homopantothenate ascorbate CoC 16 H 25 NO 11 , which can be used as an antihypoxic agent in medicine, as well as in veterinary medicine.
[0002] A method for producing cobalt(II) homopantothenate ascorbate CoC is known 16 H 25 NO 11 , exhibiting high antihypoxic activity, which suggests the possibility of its use in medicine [1].
[0003] The method involves the action of cobalt(II) sulfate on a solution of calcium ascorbate and homopantothenate, resulting in the target product in 90% yield [1]. The disadvantages of this method include the need to separate the calcium sulfate formed as a by-product by centrifugation, which increases the time required to obtain the target compound and leads to a decrease in its yield. Furthermore, the resulting cobalt(II) homopantothenate ascorbate contains an admixture of calcium sulfate, which is a poorly soluble compound and is not completely separated by this method of production, preventing the production of a pure target product.
[0004] The objective of the invention is to develop a new method which consists of using cobalt(II) homopantothenate and ascorbate as starting materials and a reaction between them in an aqueous solution, and which is free from the above mentioned disadvantages.
[0005] Method for producing cobalt(II) homopantothenate ascorbate CoC16 H 25 NO 11 consists of the interaction of cobalt(II) homopantothenate Co(C 10 H 18 NO5)2 and cobalt(II) ascorbate Co(C6H7O6)2, taken in equimolar proportions, in an aqueous solution with constant mechanical stirring at room temperature for 30-35 minutes until a transparent solution is obtained, followed by evaporation in a water bath to half the volume, precipitation of the target product with acetone and its subsequent separation.
[0006] Example 1. 7.85 g (0.015 mol) of cobalt(II) homopantothenate and 6.14 g (0.015 mol) of cobalt(II) ascorbate are dissolved in 50 ml of water and stirred at room temperature for 30 minutes. The resulting solution is evaporated to half its volume in a water bath, and 0.25 l of acetone is added. The resulting precipitate is separated from the aqueous acetone solution by decantation, washed with small portions of acetone, and ground to obtain a dry, lilac-colored powder of the target product.
[0007] The compound is obtained as an amorphous lilac powder weighing 13.01 g, the yield is 93%.
[0008] The following compounds were found in the analysis, mass %: C-41.29, H-5.41, N-3.23, O-37.63, Co-12.44.
[0009] Calculated, mass. %: C-41.20, N-5.36, N-3.00, O-37.78, Co-12.66.
[0010] The IR spectra of the synthesized compound are identical to the IR spectra of C 16 H 25 NO 11 Co, obtained by method [1]. The identity of the compound was confirmed by thin-layer chromatography.
[0011] Example 2. 7.85 g (0.015 mol) of cobalt(II) homopantothenate and 6.14 g (0.015 mol) of cobalt(II) ascorbate are dissolved in 50 ml of water and stirred at room temperature for 35 minutes. The resulting solution is evaporated to half its volume in a water bath, and 0.25 L of acetone is added. The resulting precipitate is separated from the aqueous acetone solution by decantation, washed with small portions of acetone, and ground to obtain a dry, lilac-colored powder of the target product.
[0012] The compound is obtained as an amorphous lilac powder weighing 12.87 g, the yield is 92%.
[0013] When analyzing the compound, the following was found, mass %: C-41.52, H-5.21, N-3.11, O-37.46, Co-12.70.
[0014] Calculated, mass %: C-41.20, H-5.36, N-3.00, O-37.78, Co-12.66. The IR spectra of the synthesized compound are identical to the IR spectra of C 16 H 25 NO 11 Co, obtained by method [1]. The identity of the compound was confirmed by thin-layer chromatography.
[0015] Example 3. Dissolve 15.7 g (0.03 mol) of cobalt(II) homopantothenate and 12.28 g (0.03 mol) of cobalt(II) ascorbate in 100 ml of water and stir at room temperature for 30 minutes. The resulting solution is evaporated to half its volume in a water bath, and 0.5 L of acetone is added. The resulting precipitate is separated from the aqueous acetone solution by decantation, washed with small portions of acetone, and ground to obtain a dry, lilac-colored powder of the target product.
[0016] The compound is obtained as an amorphous lilac powder weighing 26.30 g, the yield is 94%.
[0017] When analyzing the compound, the following was found, mass %: C-40.92, H-5.53, N-2.86, O-37.84, Co-12.85.
[0018] Calculated, mass %: C-41.20, H-5.36, N-3.00, O-37.78, Co-12.66. The IR spectra of the synthesized compound are identical to the IR spectra of C 16 H 25 NO 11 Co, obtained by method [1]. The identity of the compound was confirmed by thin-layer chromatography.
[0019] Sources of information taken into account during the examination.
[0020] 1. Fridman Ya.D., Sarbaev D.S., Kebets N.M., et al. Cobalt homopantothenate-ascorbate exhibiting antihypoxic activity. Author's certificate No. 1579028 dated March 15, 1990 for application No. 4397539 dated March 25, 1988.